Protein Alignment CG1582 and DHX16

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_003578.2
• Gene: DHX16 / 8449
• HGNCID: 2739
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 1184
• Identity: 318/1184 - (26%)
• Similarity: 493/1184 - (41%)
• Gaps: 310/1184 - (26%)

  Fly   160 RIPDEEQLTLEPPSEQEILDMRADEKEALESIFDKAYE--EREANRVWNLKFRIDHLLAHSPSEV 222
            |:.|.:.|.|..|:..  ..:|...|...:::.:|...  ||||..:.. |.|...||..|
Human    46 RLRDTDTLDLSGPARD--FALRLWNKVPRKAVVEKPARAAEREARALLE-KNRSYRLLEDS---- 103

  Fly   223 RKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRD-------GTCKYGPKCRFAHLPQQPTESDT 280
            .::.|..::.|.::.|.  .:||:..||.:..:.:       |..|.|...:....|:...|.:.
Human   104 EESSEETVSRAGSSLQK--KRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESEDEWER 166

  Fly   281 TKKDSVDENDNELWFHVEVR----------FPPGSRYPYEAPFIYLKTTCHD----IPHELRLRY 331
            |:::.:.:.:....|...||          .....:..||.....||....|    :| |||.:.
Human   167 TERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVP-ELRKKS 230

  Fly   332 AR-HLYKEAKEICRDGIPCVYSICDL---LQSNEQLAGRLDTSAFPSPKRSLFYD--------EP 384
            .| :|.|..:|          .:.||   |...|.|.|.::.|.  ..::.|.|.        |.
Human   231 RREYLAKRERE----------KLEDLEAELADEEFLFGDVELSR--HERQELKYKRRVRDLAREY 283

  Fly   385 AGGGVNPDAE---HHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQ--------QFVER- 437
            ...|.....|   .:..||.:   |||.:|.....:....|...|.||..:        :|..|
Human   284 RAAGEQEKLEATNRYHMPKET---RGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARD 345

  Fly   438 --RKEERYQKIIDG------------------------------------RKQLPAFAEIERILA 464
              .:|.:||.:::.                                    |:.||.|...|.:||
Human   346 AASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLA 410

  Fly   465 LIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERV 529
            .|.:..|::|.||||.||:||:||::.:..:..          ..::|.||||||::|:.||.||
Human   411 AIANHQVLIIEGETGSGKTTQIPQYLFEEGYTN----------KGMKIACTQPRRVAAMSVAARV 465

  Fly   530 AAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESD 594
            |.|...::|..|||.||.|:..|:.|.|.:.|.|:|||...|:|.|.|.:.|:|||.|||:..:|
Human   466 AREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTD 530

  Fly   595 FLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVM 659
            .|..::|::.|.|.:|||::.|||::.|.||.:|..|||..||||.|||...:
Human   531 ILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFY------------ 583

  Fly   660 EYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYL 724
                     .|..|.:.||                                       .|
Human   584 ---------TKAPEADYLE---------------------------------------AC----- 595

  Fly   725 MEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNA-LFSPRAGKFILV 788
                      :.|||:.     |.....|.||:||.|..||::..:.|.|.. ....:..:.:::
Human   596 ----------VVSVLQI-----HVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVL 645

  Fly   789 PLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLD 853
            |:::.|..:.||.:|:..|||.||:|::|||||||:||:..::|:|.|..|:|.::....||||.
Human   646 PIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLT 710

  Fly   854 LVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFAS 918
            :...|:|:|.||.||||||..|.|..|||::.||:.:....||||||..|..:||.:|:|.....
Human   711 VTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDL 775

  Fly   919 RNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQ 983
            .:     .:.|:.|..:::|.||.:|..:|||:...:||..|..:|.||||..:.|::|....:.
Human   776 MH-----FDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYS 835

  Fly   984 CLDSVLTIAACLS-NKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAAS 1047
            |.:.:||:||.|| |.|.|..|.:|...||..:..|.|...|||.:||.|.:|.:    ..|  |
Human   836 CSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAE----SGY--S 894

  Fly  1048 RNYASEHFLSLNTLETIADLKYQYLELL--VSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDN 1110
            ..:..|:|:...::....|::.|...||  |.:|.          ::|             .||
Human   895 SQWCYENFVQFRSMRRARDVREQLEGLLERVEVGL----------SSC-------------QGD- 935

  Fly  1111 NRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVK------IHPSS 1169
                        |..:.|.:|....|              |..|....|...||      |||:|
Human   936 ------------YIRVRKAITAGYFY--------------HTARLTRSGYRTVKQQQTVFIHPNS 974

  Fly  1170 VNSQVSVF--QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWI 1232
                 |:|  |..:|::.|.|.|:..::|.                          :..:||.|:
Human   975 -----SLFEQQPRWLLYHELVLTTKEFMRQ--------------------------VLEIESSWL 1008

  Fly  1233 I------LKAHDLE 1240
            :      .||.:||
Human  1009 LEVAPHYYKAKELE 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661	47/218 (22%)
		zf-CCCH	245..272	CDD:459885	6/33 (18%)
		HrpA	452..>1075	CDD:441249	209/624 (33%)
		OB_NTP_bind	1114..1212	CDD:400182	21/105 (20%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..207		18/111 (16%)
		PTZ00121	<148..376	CDD:173412	47/243 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..391		0/19 (0%)
		HrpA	398..>1025	CDD:441249	244/807 (30%)
		DEAH box	520..523		2/2 (100%)