DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and AT1G48650

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001154411.1	Gene:	AT1G48650 / 841287	AraportID:	AT1G48650	Length:	1206	Species:	Arabidopsis thaliana

Alignment Length:	957	Identity:	337/957 - (35%)
Similarity:	521/957 - (54%)	Gaps:	155/957 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 AFPSPKRSLFYDEP--------AGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTREN 427
            :|...|::|..:.|        |.|..|     :::|:       ...:|....:|.:..::.:.
plant   224 SFLDQKKTLIPEMPRQNSSESLANGYGN-----YETPE-------TVMQNSLARERILRPRSLQL 276

  Fly   428 RRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD 492
            :...||:|:   ....||::..||.|||:.|.:.:|..|.::.|||:||||||||:||:||:||:
plant   277 KSKQQQWVD---SPEGQKMVGFRKTLPAYKEKDALLKAIAANQVVVVSGETGCGKTTQLPQYILE 338

  Fly   493 NWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRL 557
            :      ::.|..... ..||||||||:|||.|:|||||||.::||:.|||::|||....:.|||
plant   339 S------EIEAARGAT-CSIICTQPRRISAISVSERVAAERGEQIGESVGYKVRLEGMRGRDTRL 396

  Fly   558 SFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAA 622
            .|||||:|||||..|..|..||||:|||:|||....||||::||:||..|.|||:|||||||||.
plant   397 LFCTTGVLLRRLLVDRSLKGVTHVVVDEIHERGMNEDFLLIVLKDLLPRRPDLKLILMSATLNAE 461

  Fly   623 LFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDF-------VMEYDTKYCRKLKKQEQ------ 674
            |||.||||||.:.|||.|:||:..||||.||.|.:       :.:|..:...|::||.|
plant   462 LFSSYFGGAPAMHIPGFTYPVRAHFLEDYLETSGYRLTTYNQIDDYGEEKTWKMQKQAQFKKRKS 526

  Fly   675 ---EILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIE 736
               ..:|..||.||                         :..|:..|..|:....|.:|...|||
plant   527 LISSAVEDALEAAD-------------------------FKGYNFRTRDSLSCWSPDSIGFNLIE 566

  Fly   737 SVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQAL 801
            :||.:||:|.    |.|.:|:|:.|:.:|.|:.:.|..::|... ..|.:|:..|.:::..:|.|
plant   567 NVLCHIVKGE----RPGAVLVFMTGWDDINSLKNQLEAHSLLGD-PNKVLLLACHGSMASSEQRL 626

  Fly   802 VFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRK 866
            :|.:.|.|.|||||:||:||||:||:|.|:|:|||..||..:|:..|...|...|:|:|.|:||:
plant   627 IFDRPPEGIRKIVLATNMAETSITINDVVYVIDCGKAKETSYDALNNTPCLLPSWISKAAARQRR 691

  Fly   867 GRAGRVMPGVCIHLYTSYRYQYHILAQ-PVPEIQRVPLEQIVLRIKTL-----QTFASRNTLSVL 925
            |||||||||.|.|||.  |..|...|. ..||:.|.||:.:.|:||:|     ..|.||
plant   692 GRAGRVMPGECYHLYP--RCVYEAFADYQQPELLRTPLQSLCLQIKSLGLGSISEFLSR------ 748

  Fly   926 LETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLT 990
              .|:.|...||..|:..|:.:||||.::.|||||.:|:.|||:.::||:::.||||.|||.|:|
plant   749 --ALQPPEALSVQNAVEYLKIIGALDDDENLTPLGKNLSMLPVEPKLGKMLILGAIFNCLDPVMT 811

  Fly   991 IAACLSNKSPFVSPLNKRTEADKCKRMFALGN--SDHLTVLNAYRKWLDVAR-RGNYAASRNYAS 1052
            :.|.||.:.||:.|.:|:..|:..:..|: |.  |||||::.||..|.|..| ...|    :|..
plant   812 VVAGLSVRDPFLMPFDKKDLAETARSKFS-GRDYSDHLTLVRAYNGWKDAERTHSGY----DYCW 871

  Fly  1053 EHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSL 1117
            ::|||..||:.:..::.|:..||            :..:..|||...:.:..:.:     |:.::
plant   872 KNFLSSQTLKAMDSMRKQFFNLL------------KEASLIDNIEGCSKLSHDEH-----LVRAI 919

  Fly  1118 LCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFL 1182
            :||.::|.:..::..::                 .:..||..||.|.::.||||..|.:...|:|
plant   920 ICAGMFPGVCSVVNKEK-----------------SITLKTMEDGQVLLYSSSVNGNVPMIPFPWL 967

  Fly  1183 VFQEKVRTSAIYIRDCSMLPLIAMVLF------AGSDFKVELHDGDFLFLLESGWIILKAHDLET 1241
            ||.:||:.:::::||.:.:....::||      .|.|..:::..|...|.::.          ..
plant   968 VFNDKVKVNSVFLRDSTAVSDSVLLLFGDKISSGGFDGHLKMLGGYLEFFMKP----------TL 1022

  Fly  1242 AEMVQCLRAEMIKLLEEKIRDPCLNL-LHHKNGCRMIANIVHLISKN 1287
            |.....|:.|:.:|::.|:.:|.|:: |:.|    ::..|..|:|::
plant  1023 AYTYLSLKRELDELIQNKLVNPKLDIQLYDK----LMTAIRLLVSED 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	309/811 (38%)
		DEXDc	471..619	CDD:238005	87/147 (59%)
		HELICc	781..871	CDD:197757	41/89 (46%)
		HA2	948..1029	CDD:214852	39/82 (48%)
		OB_NTP_bind	1070..1212	CDD:285018	30/147 (20%)
AT1G48650	NP_001154411.1	HrpA	276..1127	CDD:224557	327/893 (37%)
		DEXDc	316..458	CDD:238005	87/148 (59%)
		Helicase_C	567..660	CDD:278689	38/97 (39%)
		HA2	768..851	CDD:214852	39/83 (47%)
		OB_NTP_bind	888..998	CDD:285018	30/143 (21%)
		dsrm	1102..1163	CDD:278464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I1108
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	558	1.000	Inparanoid score	I250
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		otm3120
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770