DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and HVT1

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_850154.2	Gene:	HVT1 / 817631	AraportID:	AT2G30800	Length:	1299	Species:	Arabidopsis thaliana

Alignment Length:	991	Identity:	320/991 - (32%)
Similarity:	491/991 - (49%)	Gaps:	208/991 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 RKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDN-WFFRALQL 501
            :|::..::|...|.:||..:..:.|.:.:||:.|::|||||||||:|||||::||: |..:
plant   172 KKDKALKEITKLRSKLPITSFKDAITSAVESNQVILISGETGCGKTTQVPQYLLDHMWSSK---- 232

  Fly   502 PAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILL 566
              :|.   .:|:||||||:||:.|:||::.||.:.||:.:||::||::|..:.:.:.|||.||||
plant   233 --RET---CKIVCTQPRRISAMSVSERISCERGESIGENIGYKVRLQSKGGRHSSVVFCTNGILL 292

  Fly   567 RRLASDPLLGSV---THVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYF 628
            |.|.....:.||   ||:||||:|||...|||:|.|:::||.....|::|||||||:|..||.||
plant   293 RVLVGKGSVSSVSDITHIIVDEIHERDCYSDFMLAIIRDLLPSNPHLRLILMSATLDAERFSGYF 357

  Fly   629 GGAPVLDIPGRTFPVQQLFLEDI----------------LEMSDFVMEYDTKYCRKLKKQEQEIL 677
            ||.||:.:||.|:||:.|:|||:                |.:||..::...:  .||...|..||
plant   358 GGCPVVRVPGFTYPVRTLYLEDVLSILKSGGDNHLSSTNLSISDHKLDLTDE--DKLALDEAIIL 420

  Fly   678 -------ERELEYADVQASGEA----------------PGK------------------KIKD-- 699
                   :..|:....:.|.|.                .||                  |.||
plant   421 AWTNDEFDALLDLVSSRGSHEIYNYQHQSTWLTPLMVFAGKGRISDVCMLLSFGADWSLKSKDGM 485

  Fly   700 ---------EKLTLAETYQRYAEYSKPTC-KSIYLMEP--MTINPE-----LIESVLKYIVEGSH 747
                     .:|..|:..:.:|:.|:... :...|::.  .|||||     ||:.:::.|...|.
plant   486 TALELAEAENQLEAAQIIREHADNSQSNSQQGQQLLDKYMATINPEQVDVSLIQQLMRKICGDSE 550

  Fly   748 DWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRK 812
            |    |.||:||||:.:|......||:|..|:..| ||.::.|||.:...:|..||.:.|||.||
plant   551 D----GAILVFLPGWDDINKTRQRLLENPFFADSA-KFDIICLHSMVPAGEQKKVFNRPPPGCRK 610

  Fly   813 IVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVC 877
            |||:|||||::|||||.|:|:|.|.||||.:|...|:.:|...|||:||||||:|||||..||:|
plant   611 IVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNNVSTLQSSWVSKANAKQRQGRAGRCQPGIC 675

  Fly   878 IHLYTSYRYQYHILAQP---VPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLG 939
            .|||:..|    ..:.|   ||||:|:|:|::.|::|.|......|  ..|.:.|:.|.:.|:..
plant   676 YHLYSRLR----AASMPDFKVPEIKRMPVEELCLQVKILDPNCKTN--DFLQKLLDPPVDQSIAN 734

  Fly   940 ALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSP 1004
            ||:.|:|:|||..:::||.||.....|||...|.|::.:..:..|||..||:|.....|.||..|
plant   735 ALSILQDIGALTPQEELTELGEKFGHLPVHPLISKMLFFAVLVNCLDPALTLACAADYKEPFTMP 799

  Fly  1005 LN--KRTEADKCKRMFAL---GNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETI 1064
            ::  :|.:|...|...|.   |:||||.|:.|:..|.:...||   .|..:.|::|:|.:.::.:
plant   800 MSPVERQKAAAAKLELASLCGGDSDHLAVVAAFECWKNAKGRG---LSAEFCSQYFVSPSAMKML 861

  Fly  1065 ADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKI 1129
            ..::.|....|...|.:|.|:     ::|           :.|..:..:|.::|...|||.:.::
plant   862 DQMRSQLESELKRHGIIPNDI-----SSC-----------SQNSRDPGILRAVLAVGLYPMVGRL 910

  Fly  1130 M----TPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVS--VFQAPFLVFQEKV 1188
            .    ...|..::||.||                  .|::|..|.|..:|  .:....|||.|..
plant   911 CPAFGNNRRTIVETASGA------------------KVRVHSLSNNFNLSSKKYDESLLVFDEIT 957

  Fly  1189 R-TSAIYIRDCSM---LPL------IAMVLFAGSD------------------------------ 1213
            | ...::||:|::   |||      ||:.....||
plant   958 RGDGGMHIRNCTVARDLPLLLISTEIAVAPTGSSDSDDSNEEEEDDEEVAANTNEEVAANTNEEG 1022

  Fly  1214 ---FKVELHDG--------DFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNL 1267
               .|.|...|        :.:.|:...|:..:...||.|:| ..||..::..:..|:..|..:|
plant  1023 MDIHKEESRRGAKMMSSPENSVKLVVDRWLPFRTTALEVAQM-YILRERLMASILFKVTHPREHL 1086

  Fly  1268 LHHKNGCRM--IANIV 1281
            ..|. |..|  ||.|:
plant  1087 PPHL-GASMHAIAGIL 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	297/871 (34%)
		DEXDc	471..619	CDD:238005	73/151 (48%)
		HELICc	781..871	CDD:197757	50/89 (56%)
		HA2	948..1029	CDD:214852	31/85 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	35/157 (22%)
HVT1	NP_850154.2	R3H_DEXH_helicase	22..80	CDD:100077
		HrpA	153..>946	CDD:224557	285/832 (34%)
		ANK repeat	417..444	CDD:293786	5/26 (19%)
		ANK repeat	446..481	CDD:293786	2/34 (6%)
		PTZ00322	453..>506	CDD:140343	7/52 (13%)
		ANK repeat	483..507	CDD:293786	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I1108
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820