DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx36

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_082412.2	Gene:	Dhx36 / 72162	MGIID:	1919412	Length:	1001	Species:	Mus musculus

Alignment Length:	1013	Identity:	380/1013 - (37%)
Similarity:	560/1013 - (55%)	Gaps:	140/1013 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELRLRYARHLYKEAKEICRDGIPCVY-------SICDLLQSNEQLAGRLDTSAFPSPKRSLFYDE 383
            |:.|.||:...::.||..|.....|:       .|..||.|.:....: |:.|    :.|.|..|
Mouse    54 EIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKTDK-DSEA----QISWFAPE 113

  Fly   384 PAGGGVNPDAE---------HHQSPKPSHYARGQTSRNDGGH-QRNVEAQTREN-------RRLL 431
            ..|.|....:|         .:|..|..:..:......|..: .|:.|...:||       :.||
Mouse   114 DHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTFRITDKSYIDRDSEYLLQENEPNLSLDQHLL 178

  Fly   432 QQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFF 496
            :....::.:.||.::...||:||::...:.::.||.:..|.||||||||||:|||.||||||:..
Mouse   179 EDLQRKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIE 243

  Fly   497 RALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRI--GQLVGYQIRLENKVSQST-RLS 558
            |......:       |:||||||:|||.||||||.||.:..  |...||||||::::.:.. .:.
Mouse   244 RGKGSACR-------IVCTQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSIL 301

  Fly   559 FCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAAL 623
            :|||||:|:.|.||..|.||:|:::||:|||:.:||.|:.::|:||..|.|||||||||||||..
Mouse   302 YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEK 366

  Fly   624 FSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFV---MEYDTKYCR-----KLKKQEQEILERE 680
            ||:|||..|::.|||.||||.:..||||:|...:|   .|:.:::.|     .:.:||:|  |:|
Mouse   367 FSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKE--EKE 429

  Fly   681 LEYADVQASGEAPGKKIKDEKLTLAETYQRY-----AEYSKPTCKSIYLMEPMTINPELIESVLK 740
            ..|                     .|.:..|     ..||..|...:.:|:...::..||.::::
Mouse   430 AIY---------------------KERWPAYIKELRTRYSASTVDVLQMMDDDKVDLNLIAALIR 473

  Fly   741 YIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKK 805
            |||....|    |.||:||||:..|.::||.|:...:|  ::.||:::||||.:...:|..||||
Mouse   474 YIVLEEED----GAILVFLPGWDNISTLHDLLMSQVMF--KSDKFLIIPLHSLMPTVNQTQVFKK 532

  Fly   806 APPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAG 870
            .|||.||||::|||||||:||||.|:|:|.|.:||..||:..|:.::...|||:|||||||||||
Mouse   533 TPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAG 597

  Fly   871 RVMPGVCIHLYTSYR------YQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETL 929
            ||.||.|.|||...|      ||       :|||.|.|||::.|:||.|:.......||.|   :
Mouse   598 RVQPGHCYHLYNGLRASLLDDYQ-------LPEILRTPLEELCLQIKILRLGGIAYFLSRL---M 652

  Fly   930 EAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAAC 994
            :.|:.::|:.::..|.::.|||.:::|||||.|||.|||:..|||::|:||:|.|||.||||||.
Mouse   653 DPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAAS 717

  Fly   995 LSNKSPFVSPLNKRTEAD-KCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSL 1058
            ||.|.|||.||.|...|| :.|.:.....||||||:||:..|.:..||| :...::|..|:|||.
Mouse   718 LSFKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRG-FRYEKDYCWEYFLSS 781

  Fly  1059 NTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALY 1123
            |||:.:.::|.|:.|.|:..|||....|:..|             .|.|.||.:::.:::||.||
Mouse   782 NTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPK-------------ANINSDNEKIIKAVICAGLY 833

  Fly  1124 PNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKV 1188
            |.:.||    |:.:......|         :..|:.||.|.|||.|||.:.:.|...:|::..|:
Mouse   834 PKVAKI----RLNLGKKRKMV---------KVHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKM 885

  Fly  1189 RTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMI 1253
            |||:||:.||:.:....: ||.|.|..:: .|.|...:....||:.::.: ..|.:|:.||.|:.
Mouse   886 RTSSIYLYDCTEVSPYCL-LFFGGDISIQ-KDKDQEIIAVDEWIVFQSPE-RIAHLVKGLRKELD 947

  Fly  1254 KLLEEKIRDPCLNLLH-------HKNGCRMIANIVHLI 1284
            .||:|||..|     |       ....|.:::.|:.||
Mouse   948 SLLQEKIESP-----HPVDWDDTKSRDCAVLSAILDLI 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440	11/40 (28%)
		HrpA	419..1206	CDD:224557	332/816 (41%)
		DEXDc	471..619	CDD:238005	80/150 (53%)
		HELICc	781..871	CDD:197757	51/89 (57%)
		HA2	948..1029	CDD:214852	47/81 (58%)
		OB_NTP_bind	1070..1212	CDD:285018	43/141 (30%)
Dhx36	NP_082412.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..193		31/143 (22%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000250\|UniProtKB:D4A2Z8	1..97		12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		380/1013 (38%)
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..44
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	46..98		12/43 (28%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	46..68		4/13 (31%)
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	99..379		115/291 (40%)
		HrpA	188..894	CDD:224557	325/778 (42%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	258..310		25/51 (49%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	327..330		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	380..621		107/276 (39%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	491..550		28/60 (47%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	510..521		6/10 (60%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	622..691		29/71 (41%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	631..690		21/61 (34%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	834..898		25/76 (33%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	842..853		1/19 (5%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	863..893		13/29 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4756
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1595
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750