DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx34

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001272860.1	Gene:	Dhx34 / 71723	MGIID:	1918973	Length:	1145	Species:	Mus musculus

Alignment Length:	942	Identity:	303/942 - (32%)
Similarity:	434/942 - (46%)	Gaps:	236/942 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 ENRRLLQQFVERRKEERYQKIID---GRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVP 487
            |.||.|..:::.::::.:.:::.   .|..||......|||..::...|||::|:||||||||||
Mouse   134 EFRRALLHYLDFQQKQAFGRLVKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVP 198

  Fly   488 QFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVS 552
            |::|...|            .||  .||||||::.|.:|:||..|.|.:.|..||||||.|:..|
Mouse   199 QYLLAAGF------------SHV--ACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRS 249

  Fly   553 QSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSA 617
            .:|::.|.|.|:|||::..:|.|.....:||||||||...:||||.:|:.||.:|.|||||||||
Mouse   250 AATKIVFLTVGLLLRQIQREPSLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSA 314

  Fly   618 TLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELE 682
            |:|.:|||.||..|||:.:|||.||:..::                        |.||
Mouse   315 TINISLFSSYFSHAPVVQVPGRLFPITVVY------------------------QPQE------- 348

  Fly   683 YADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSH 747
             ||..||        |.|||                            :|.....||:.|   .:
Mouse   349 -ADQTAS--------KSEKL----------------------------DPRPFLRVLEAI---DN 373

  Fly   748 DWPRE--GTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGK 810
            .:|.|  |.:|:||.|..||.:|.|:....|..:.|   ::::|||||||..||..||..||.|.
Mouse   374 KYPPEERGDLLVFLSGMAEITTVLDAAQAYASLTQR---WVVLPLHSALSVSDQDKVFDVAPAGV 435

  Fly   811 RKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPG 875
            ||.:|||||||||||||...||||.|.:||..:|....::.|...|:|:|:|:||||||||..||
Mouse   436 RKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPG 500

  Fly   876 VCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGA 940
            ||..||....|. .....|||||:||.|:.:||::|::.....|.     ...:|.|...||..|
Mouse   501 VCYRLYAESDYD-AFAPYPVPEIRRVALDALVLQMKSMSVGDPRT-----FPFIEPPPPASVETA 559

  Fly   941 LTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPL 1005
            :..|::.||||:.:.|||:|..||.|||||.|||:::.|::|...:.||||||.||.:|||....
Mouse   560 ILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFTRSA 624

  Fly  1006 NKRTEADKCKRMFALGNSDHLTVLNAYRKWLDV--ARRGNYAASRNYASEHFLSLNTLETIADLK 1068
            ....:....:|.......|..|:.|.:..|:.|  .|.||   ||.:.....:..:.|..:|:|:
Mouse   625 QSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGN---SRKWCRRRGVEEHRLYEMANLR 686

  Fly  1069 YQYLELLVSIGFV---PIDVP----------------------------RRRK------NAC--- 1093
            .|:.|||...|.:   .:..|                            ||||      :.|
Mouse   687 RQFKELLEDHGLLSGAQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRKVLRLQEDGCSSD 751

  Fly  1094 ----------------------------DNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIM 1130
                                        :.:.......|:...|...||..:|...|||.:
Mouse   752 EEDREGSTSQRADSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQL---- 812

  Fly  1131 TPDRVYIQTAGGAVP------REPSHHDLRFKTRGDGYVKIHPSSV--NS--------------- 1172
                        |||      |:.|  |..|.|:......:||:.|  ||
Mouse   813 ------------AVPDAFNSGRKDS--DQIFHTQAKQGTVLHPTCVFANSPEVLHTQGQEASGQE 863

  Fly  1173 -------QVSVFQAPFLVFQEKVRTSAIYIRDCSMLP-LIAMVLFAGSDFKVELHDGDFLFLLES 1229
                   |:|. :...|.|...:.|:..|:.:|..:| |.:::||:.|   ::. :||...|:..
Mouse   864 GSQDGRDQMSC-KHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRS---IDT-NGDCSRLVAD 923

  Fly  1230 GWIILKAHDLETAEMVQCLRAEMIKLLEEKIR 1261
            ||:.|:..|.|:|          ::||...:|
Mouse   924 GWLELQLADSESA----------VRLLATSLR 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	288/885 (33%)
		DEXDc	471..619	CDD:238005	74/147 (50%)
		HELICc	781..871	CDD:197757	49/89 (55%)
		HA2	948..1029	CDD:214852	34/80 (43%)
		OB_NTP_bind	1070..1212	CDD:285018	43/240 (18%)
Dhx34	NP_001272860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		HrpA	153..>688	CDD:224557	243/631 (39%)
		DEAH box	281..284		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..764		5/37 (14%)
		OB_NTP_bind	800..910	CDD:369483	29/128 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820