Protein Alignment CG1582 and YTHDC2

DIOPT Version :9

• Sequence 1: NP_001285098.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_011541883.1
• Gene: YTHDC2 / 64848
• HGNCID: 24721
• Length: 1439
• Species: Homo sapiens
• Alignment Length: 1050
• Identity: 335/1050 - (31%)
• Similarity: 494/1050 - (47%)
• Gaps: 252/1050 - (24%)

  Fly   411 RNDGGHQRNVEAQTRE----NRRL---LQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            :.:.|:...|||:.||    :.||   :.|...:|.|..:...   |:.||.|.:.|.|:.:|:.
Human   147 KTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSF---RQSLPVFEKQEEIVKIIKE 208

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            :.||:|.||||.||:||:|||:||:.|        |..:| ..|.|||||||:||.|||||||||
Human   209 NKVVLIVGETGSGKTTQIPQFLLDDCF--------KNGIP-CRIFCTQPRRLAAIAVAERVAAER 264

  Fly   534 LDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRL-ASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .:||||.:|||||||::||..|.|:|||.|:|||.| |.|..|.:||||||||||||...|||||
Human   265 RERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLL 329

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            ..|::||::...||:||.||.|:..||..|||..||:.|.||.|.|:::||||||..:.:..:..
Human   330 TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEM 394

  Fly   663 TKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRY-----AEYSKPTCKSI 722
            .|| :|.|:||::......|:...|.:...|..:.:...|.:.:.|...     |.:|:.|.|.:
Human   395 LKY-KKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDV 458

  Fly   723 YLMEPMTINP------------------------------------------------------- 732
            ..:||..|..
Human   459 NCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQV 523

  Fly   733 ---------------------------------ELIESVLKYIVEGS------------------ 746
                                             :|:||....:..|:
Human   524 EQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAED 588

  Fly   747 --------HDWPRE--------------------GTILIFLPGFGEIQSVHDSLL-DNALFSPRA 782
                    |.:..|                    |.:||||||:.||..:.|.:| |:..|:...
Human   589 RELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADST 653

  Fly   783 GKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNR 847
            .::.:..|||.:...||..|.|..|.|.|||:|||||||||:|::|.|||:|.|.:|||.||:..
Human   654 HRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 718

  Fly   848 NMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKT 912
            .:..|.:||:|:|:|.||||||||..||:|..|::..|:| ::|....||:.|:||:::.|..|.
Human   719 FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ-NMLEFQTPELLRMPLQELCLHTKL 782

  Fly   913 LQTFASRN--TLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKL 975
            |   |..|  ....|::..|.|....|..|:..|:.:.|:|..:.||.||:|||.|||:..:||:
Human   783 L---APVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKM 844

  Fly   976 MLYGAIFQCLDSVLTIAACLSNKSPFVSP--LNKRTEADKCKRMFALGN-SDHLTVLNAYRKWLD 1037
            :|...:.:|||.:||||..|:.:.|||.|  .:::..|..|::.|..|. |||:.:|.|::.| .
Human   845 VLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAW-Q 908

  Fly  1038 VARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGV 1102
            .||...:  .|.:..::|||..|:|.|..::.|.|..|.:.|||      |.:...|    :..|
Human   909 KARSDGW--ERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV------RARGGGD----IRDV 961

  Fly  1103 EQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHP 1167
              |.|.:|..::.:.|.|.:|||:|.:   ||..:...|   |:|..             |:.||
Human   962 --NTNSENWAVVKAALVAGMYPNLVHV---DRENLVLTG---PKEKK-------------VRFHP 1005

  Fly  1168 SSVNSQ---------------VSVFQAPFLVFQEKVRTSAI-YIRDCSMLPLIAMVLFAG----- 1211
            :||.||               :......:|::.|..|...| .||.||.:..:.:::|.|
Human  1006 ASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLA 1070

  Fly  1212 -------SDFKV----------ELHD---GDFLFLLESGWIILKAH---DLETAEMVQCLRAEMI 1253
                   |.|:|          |:.|   .:...|....|:    |   :.|.|.::..||.:..
Human  1071 SNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWL----HFTLEPEAASLLLQLRQKWH 1131

  Fly  1254 KLLEEKIRDP 1263
            .|...::|.|
Human  1132 SLFLRRMRAP 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	317/955 (33%)
		DEXDc	471..619	CDD:238005	90/148 (61%)
		HELICc	781..871	CDD:197757	45/89 (51%)
		HA2	948..1029	CDD:214852	34/83 (41%)
		OB_NTP_bind	1070..1212	CDD:285018	40/169 (24%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	189..>1016	CDD:224557	299/877 (34%)
		DEXHc_YTHDC2	193..368	CDD:350745	104/183 (57%)
		ANK repeat	505..537	CDD:293786	0/31 (0%)
		ANK repeat	539..564	CDD:293786	3/24 (13%)
		OB_NTP_bind	971..1066	CDD:369483	27/113 (24%)
		YTH	1288..1404	CDD:367840

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820