DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and dhx8

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	1225	Identity:	308/1225 - (25%)
Similarity:	496/1225 - (40%)	Gaps:	375/1225 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RTTNVPAAPKSQAAD--NKSRKTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRGG 83
            |..||        ||  :|.::.::.||........::|..:.|..|     :|::..:.|..||
Zfish   295 RVANV--------ADVVSKGQRVKVKVLSFTGSKTSLSMKDVDQDTG-----EDLNPNRRRNVGG 346

  Fly    84 HGVKHSYWQ--DRGTLVVQSVQGVSSTRGNDSDGDRLRRYALAKL---ENYGFQ---AVHCLEAY 140
            .|.:.|..:  ||.|       .::.....:.:.|.|.|..|.|:   |.:..:   |.:.|...
Zfish   347 EGQEESAMRNPDRPT-------NLNLGHAPEVEDDTLERKRLTKISDPEKWEIKQMIAANVLSKE 404

  Fly   141 EHCSGDTEAALLLLYRRYMRIPDEEQLTLE-PPSEQEILDMRADEKEALESIFDKAYEEREANRV 204
            |....|.|..:|      .::.|||...|| ...|:|...:|...|::::.
Zfish   405 EFPDFDEETGIL------PKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDM-------------- 449

  Fly   205 WNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFA 269
                         ||.::.|..:..| :.||..|:||.|:::
Zfish   450 -------------SPVKIVKNPDGSL-SQAAMMQSALAKERR----------------------- 477

  Fly   270 HLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARH 334
            .:.|...|::   .||:....|:.|.
Zfish   478 EVKQAQREAE---MDSIPMGLNKHWV--------------------------------------- 500

  Fly   335 LYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSP 399
                      |.:|.|        ...|:|..:                 .|.|:.|    :..|
Zfish   501 ----------DPLPDV--------DGRQIAANM-----------------RGIGMMP----NDIP 526

  Fly   400 KPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILA 464
            :...:|       .||::.:...:|:                  ..|::.|:.||.:...|:::.
Zfish   527 EWKKHA-------FGGNKASYGKKTQ------------------LSILEQRESLPIYKLKEQLIQ 566

  Fly   465 LIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERV 529
            .:..:.::::.||||.||:||:.|::.:..:           ....:|.||||||::|:.||:||
Zfish   567 AVHDNQILIVIGETGSGKTTQITQYLAEAGY-----------TTRGKIGCTQPRRVAAMSVAKRV 620

  Fly   530 AAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESD 594
            :.|....:||.|||.||.|:..|..|.:.:.|.|:|||....||.||....:::||.|||:..:|
Zfish   621 SEEYGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTD 685

  Fly   595 FLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVM 659
            .|..:||..:::|.|:|:|:.||||:|..||.||..||:..|||||:||:.|:
Zfish   686 VLFGLLKKTVQKRTDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEVLY------------ 738

  Fly   660 EYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYL 724
               ||             |.|.:|.|.                            |..|...|:|
Zfish   739 ---TK-------------EPETDYLDA----------------------------SLITVMQIHL 759

  Fly   725 MEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDN-ALFSPRAGKFILV 788
            .||                        .|.||:||.|..||.:..:.|.:. ....|...:.|::
Zfish   760 TEP------------------------PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIIL 800

  Fly   789 PLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLD 853
            |::|||..|.|..:|..||||.||:|::|||||||:|||...:|||.|.:|:|.::|...::.|.
Zfish   801 PVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLV 865

  Fly   854 LVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFAS 918
            :..:|:|.||||.|||||..||.|..|||...|:..:|...||||||..|...||.:|.:   ..
Zfish   866 VTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM---GI 927

  Fly   919 RNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQ 983
            .:.||  .:.::||..::::.|:.:|..:||||.|..||.||..:|..|::..:.|:::......
Zfish   928 NDLLS--FDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLG 990

  Fly   984 CLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASR 1048
            |.:.:|||.:.||.::.|..|.:|:..||:.|..|.....||||:|..|..|      .|...|.
Zfish   991 CSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQPEGDHLTLLAVYNSW------KNNKFSN 1049

  Fly  1049 NYASEHFLSLNTLETIADLKYQYLELL-------VSIGFVPIDVPRRRKNACDNILTLTGVEQNH 1106
            .:..|:|:...:|....|::.|.|.::       ||.|...:.|.:
Zfish  1050 PWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKATVRVQK------------------- 1095

  Fly  1107 NGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY--------V 1163
                      .:|:..:.|..|                 ::|.          :||        |
Zfish  1096 ----------AICSGFFRNAAK-----------------KDPQ----------EGYRTLIDQQVV 1123

  Fly  1164 KIHPSSVNSQVSVF--QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKV 1216
            .|||||     ::|  |..::|:.|.|.|:..|:|:.:.:....:|.||.:.|||
Zfish  1124 YIHPSS-----ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKV 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	9/36 (25%)
		zf-CCCH	250..272	CDD:279036	0/21 (0%)
		RWD	<284..360	CDD:283440	7/75 (9%)
		HrpA	419..1206	CDD:224557	233/804 (29%)
		DEXDc	471..619	CDD:238005	56/147 (38%)
		HELICc	781..871	CDD:197757	42/89 (47%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	29/158 (18%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189	10/45 (22%)
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	239/813 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810