DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHX35

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_068750.2	Gene:	DHX35 / 60625	HGNCID:	15861	Length:	703	Species:	Homo sapiens

Alignment Length:	833	Identity:	236/833 - (28%)
Similarity:	380/833 - (45%)	Gaps:	199/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 RKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWFFRALQLPAKENLPHVEII 513
            |::||.|.....||.|||:...|||.||||||||||:||::.: .|       .|:..:..|
Human    51 RQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-------TAEGRVVGV--- 105

  Fly   514 CTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQ-STRLSFCTTGILLRRLASDPLLGS 577
             |||||::|:.||.|||.||...:|..|||.||.::...| :||:.|.|.|:|:|.:..||||..
Human   106 -TQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTK 169

  Fly   578 VTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFG----------GAP 632
            .:.:::||.|||:..:|..:.:||.:.::|.||::|:.||||:|..|.|:|.          ...
Human   170 YSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCV 234

  Fly   633 VLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKI 697
            :|.:.||||||      ||
Human   235 ILTVEGRTFPV------DI---------------------------------------------- 247

  Fly   698 KDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGF 762
                                    .||..|:   |:.|:|.::.:|: .|....:|.:|.||.|.
Human   248 ------------------------FYLQSPV---PDYIKSTVETVVK-IHQTEGDGDVLAFLTGQ 284

  Fly   763 GEIQSVHDSLLDNALFSPRAG---KFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSV 824
            .|:::|...|::.|....|.|   ...::|:::.|...:|..||::.....||::::||:||||:
Human   285 EEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSI 349

  Fly   825 TIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYH 889
            ||...|:|:|||.:|.:.::....:|.|.:|.||:|:|.||.||.||...|.|..|||...:. .
Human   350 TISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFD-K 413

  Fly   890 ILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAED 954
            :....|||:||..|..::|::|.|   ...|.|.  ...:..|...|::.||..|..:|.||.:.
Human   414 LPQSTVPEMQRSNLAPVILQLKAL---GIDNVLR--FHFMSPPPAQSMVQALELLYALGGLDKDC 473

  Fly   955 QLT-PLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMF 1018
            :|| |||..:|..|::....|::|....|.|...:|:|||.:..::.||.|.|:::.|.:..|.|
Human   474 RLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKF 538

  Fly  1019 ALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPI 1083
            |:...||||:||.|..::      .:.....:..||||:...|...|.::.|..:|||.     .
Human   539 AVEEGDHLTMLNIYEAFI------KHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVK-----F 592

  Fly  1084 DVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREP 1148
            .|||:                :..||.:.:|..:: :..:.|..:.
Human   593 QVPRK----------------SSEGDPDLVLRCIV-SGFFANAARF------------------- 621

  Fly  1149 SHHDLRFKT-RGDGYVKIHPSSVNSQVSVFQAP-FLVFQEKVRTSAIYIRDCSMLPLIAMVLFAG 1211
             |....::| |.|..:.|||:||   :...:.| ::::.|.::||..|:||.:
Human   622 -HSTGAYRTIRDDHELHIHPASV---LYAEKPPRWVIYNEVIQTSKYYMRDVT------------ 670

  Fly  1212 SDFKVELHDGDFLFLLESGWII-LKAHDLETAEMVQCLRAEMIKLLEEKIRDP 1263
                          .:||.|:: |..|..:....:.      :|....|::||
Human   671 --------------AIESAWLLELAPHFYQQGTHLS------LKAKRAKVQDP 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	227/773 (29%)
		DEXDc	471..619	CDD:238005	63/149 (42%)
		HELICc	781..871	CDD:197757	34/92 (37%)
		HA2	948..1029	CDD:214852	30/81 (37%)
		OB_NTP_bind	1070..1212	CDD:285018	27/143 (19%)
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	77/181 (43%)
		DEXDc	73..211	CDD:238005	63/148 (43%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	34/94 (36%)
		HA2	465..549	CDD:214852	30/83 (36%)
		OB_NTP_bind	584..683	CDD:285018	31/169 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810