DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHX37

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_005253647.1	Gene:	DHX37 / 57647	HGNCID:	17210	Length:	1175	Species:	Homo sapiens

Alignment Length:	1160	Identity:	298/1160 - (25%)
Similarity:	462/1160 - (39%)	Gaps:	280/1160 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LYRRYMRIPDEEQLTLEP---PSEQEILDMRADEKEALESIFDKAYEEREANRVWNLKFRIDHLL 215
            |.||| .|...:|....|   |.|...:.:..::|:.|:.:        :|:....|
Human     4 LRRRY-NIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGV--------DASNALVL-------- 51

  Fly   216 AHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDT 280
               |.:.:|..:|          ..|.||:|.||          .|...|.....|.|:..:|..
Human    52 ---PGKKKKKTKA----------PPLSKKEKKPL----------TKKEKKVLQKILEQKEKKSQR 93

  Fly   281 T----KKDSVDENDNEL-WFHVEVRFPPGSRYPYEAPFIYLKTTCHDI-------------PHEL 327
            .    |...|..::.|: .|:...:...|:|      ..:.|....::             .|..
Human    94 AEMLQKLSEVQASEAEMRLFYTTSKLGTGNR------MYHTKEKADEVVAPGQEKISSLSGAHRK 152

  Fly   328 RLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVN-P 391
            |.|:.....:|.:|...:......|..|...:.|.....:.|:..|.|.......:|...|:. |
Human   153 RRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVP 217

  Fly   392 DAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAF 456
            .......|.|...|:...                        |:...:....|   :.|.:||..
Human   218 PPPAAAPPLPRALAKPAV------------------------FIPVNRSPEMQ---EERLKLPIL 255

  Fly   457 AEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLS 521
            :|.:.|:..:...|:|::.||||.||:||||||:.:..|      .:::::    |..|:|||::
Human   256 SEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGF------SSEDSI----IGVTEPRRVA 310

  Fly   522 AIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEV 586
            |:.:::|||.| ::...::|.||||.|..|::.||:.|.|.|:||:.:..|.||.....||:||.
Human   311 AVAMSQRVAKE-MNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEA 374

  Fly   587 HERSEESDFLLLILKNL--LRERKD--LKVILMSATL-------NAALFSDYFGGAPVLDIPGRT 640
            ||||..:|.|:.:|..:  ||.:::  ||:::|||||       |..||:.   ..||:.:..|.
Human   375 HERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAK---PPPVIKVESRQ 436

  Fly   641 FPVQQLF-----LEDILEMSDFVMEYDTKYCRKLKK-----------------QEQEILERELEY 683
            |||...|     |||          |..:..||:.|                 .|...|.|.|..
Human   437 FPVTVHFNKRTPLED----------YSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRK 491

  Fly   684 ADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHD 748
            | ...|...|.:|..|:|.::.|  .|..:.|:...|.    ....:.|::.......:..|..|
Human   492 A-FPPSRARPQEKDDDQKDSVEE--MRKFKKSRARAKK----ARAEVLPQINLDHYSVLPAGEGD 549

  Fly   749 WPREGTILIFLPGFGEIQSVHDSLLDNAL--------FSPRAG-KFILVPLHSALSGEDQALVFK 804
            ..||..:       .|.:...||.||..|        ..|.|. ...::||:|.|:.|.||.|||
Human   550 EDREAEV-------DEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFK 607

  Fly   805 KAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRA 869
            ..|.|.|..|::||:||||:||....:|||||.:|::.:|....:.|..:.|||:|:|.||.|||
Human   608 PPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRA 672

  Fly   870 GRVMPGVCIHLYTSYRY----QYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLE 930
            ||..||.|..||:|..:    |:     |.|||.|.|:|.::|::|.|..   ...::....|
Human   673 GRTEPGHCYRLYSSAVFGDFEQF-----PPPEITRRPVEDLILQMKALNV---EKVINFPFPT-- 727

  Fly   931 APTEDSVLGALTRLRDVGALDAEDQ---------------LTPLGHHLAALPVDVRIGKLMLYGA 980
            .|:.:::|.|...|..:|||....:               :|.||..:|..||..|..|::....
Human   728 PPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSR 792

  Fly   981 IFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYA 1045
            ...||...:||.|.::.:..|       .|.|:     ...:.:.||.|.:.|     ||...
Human   793 QHGCLPYAITIVASMTVRELF-------EELDR-----PAASDEELTRLKSKR-----ARVAQ-- 838

  Fly  1046 ASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACD------NILTLTGVEQ 1104
            ..|.:|.:.          |.||..  :|:|.:|.|         .||:      ......|:..
Human   839 MKRTWAGQG----------ASLKLG--DLMVLLGAV---------GACEYASCTPQFCEANGLRY 882

  Fly  1105 NHNGDNNRLLTSLLCA--ALYPNIVKIMTPDR--------VYIQ---TAG---GAVPREPSHHDL 1153
            ....:..||...|..|  |:.|.....:.|..        .|::   |||   ....|..|...|
Human   883 KAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEML 947

  Fly  1154 RFKTRG-------DGYVKIHPSSVNSQVSVFQ--APFLVFQEKVRTSAIYIRDCS 1199
            ..|.|.       |..|.||||||     :|:  ..|:|:||.|.|:.:|::..|
Human   948 EDKWRNAYKTPLLDDPVFIHPSSV-----LFKELPEFVVYQEIVETTKMYMKGVS 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	298/1160 (26%)
		zf-CCCH	250..272	CDD:279036	2/21 (10%)
		RWD	<284..360	CDD:283440	13/89 (15%)
		HrpA	419..1206	CDD:224557	247/873 (28%)
		DEXDc	471..619	CDD:238005	59/151 (39%)
		HELICc	781..871	CDD:197757	41/90 (46%)
		HA2	948..1029	CDD:214852	21/95 (22%)
		OB_NTP_bind	1070..1212	CDD:285018	40/161 (25%)
DHX37	XP_005253647.1	HrpA	240..1016	CDD:224557	246/854 (29%)
		DEXDc	271..411	CDD:238005	59/150 (39%)
		P-loop_NTPase	<368..>511	CDD:304359	47/156 (30%)
		HELICc	585..674	CDD:197757	40/88 (45%)
		HA2	768..859	CDD:214852	29/121 (24%)
		OB_NTP_bind	894..1011	CDD:285018	31/109 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810