DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and dhx40

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_021322026.1	Gene:	dhx40 / 570225	ZFINID:	ZDB-GENE-080507-1	Length:	734	Species:	Danio rerio

Alignment Length:	856	Identity:	228/856 - (26%)
Similarity:	381/856 - (44%)	Gaps:	202/856 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 KQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICT 515
            |:||.:...::::..:|.:..::::||||.||:||:||::......|           :..|..|
Zfish    16 KKLPIYQYKDKLVQAVEENTFLIVTGETGSGKTTQLPQYLYKAGLSR-----------NGRIGVT 69

  Fly   516 QPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTH 580
            ||||::||.||:||::|...|:|:.||||:|.::..::.|.:.:.|.|.|||.:.:||.|...:.
Zfish    70 QPRRVAAITVAQRVSSEMQVRLGEEVGYQVRFDDCSTKDTMIKYMTDGCLLREILADPSLTQYSI 134

  Fly   581 VIVDEVHERSEESDFLL-LILKNLLR----ERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRT 640
            ||:||.||||..:|.|| |:.|.||:    .:..|||::|||||.....|.::|..||..|||||
Zfish   135 VILDEAHERSLNTDVLLGLLKKTLLKGSRGNKTPLKVVVMSATLETEKLSSFYGNCPVFTIPGRT 199

  Fly   641 FPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLA 705
            :||::.|                  |..:..:::|
Zfish   200 YPVKETF------------------CNLIGPKDKE------------------------------ 216

  Fly   706 ETYQRYAEYSKPTCKSIYLME--PMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSV 768
                          .|:|:.|  .||::....|:.              |.||:||.|..||:..
Zfish   217 --------------SSVYVKEVVKMTLDVHTNEAA--------------GDILVFLTGQSEIEKA 253

  Fly   769 HDSLLDNA--------LFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVT 825
            .|.|.:.|        :........:::.|:.::..:.|..:|:.||.|.||.|::||||.||:|
Zfish   254 CDLLFEKAEILDYRYDVHDRSVDGLLILSLYGSMPTDQQRQIFQPAPKGVRKCVVATNIAATSLT 318

  Fly   826 IDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHI 890
            ||...::||.|.:|:...:|...::.|::|.:|::.|:||.|||||...|.|..:|:...:...:
Zfish   319 IDGIRYIVDSGFVKQLNHNSRVGLDILEVVPISKSEAQQRAGRAGRTAAGKCFRIYSKDFWDTCM 383

  Fly   891 LAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQ 955
            ....:|||||..|..::|.:|.|....     .:....|:.|.|..:|.||.:|....|:|...:
Zfish   384 PEYTIPEIQRTSLTSVILTLKCLGVHD-----VIRFPYLDCPEERFILTALKQLYQYDAIDRRGE 443

  Fly   956 LTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSP--LNKRTEADKCKRMF 1018
            :|.||..:...|:...:.:.:|..|...|.|.:|.:||.||.::.|:.|  ..|:.||:...:..
Zfish   444 VTKLGRLMVEFPLPPNLTRALLKAAALGCEDIMLPVAAMLSVENIFIRPGKPEKQKEAEVRHKEI 508

  Fly  1019 AL---GNSDHLTVLNAYRKWLDVARRGNYAASRN---YASEHFLSLNTLETIADLKYQYLELLVS 1077
            |.   |::|.|.:|..:.|         ..||.|   :..|:::....:::...::.|..|:|:.
Zfish   509 AACSGGSNDFLMLLCVFEK---------CRASENPSAWCKENWIHWRAVKSAFSVETQLREILLR 564

  Fly  1078 IGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGG 1142
            :. ...|.|..|                ..|..:.||...||...:.|:.:         ::.|.
Zfish   565 LK-QQKDFPHER----------------FEGSRSELLRQCLCLGYFTNVAR---------RSIGK 603

  Fly  1143 AVPREPSHHDLRFKTRGDGY---VKIHPSSVNSQVSVF----QAPFLVFQEKVRTSAIYIRD-C- 1198
            :           |.|. ||:   |.|||||     .:|    |..:::|.:.:.||.:|:|. |
Zfish   604 S-----------FCTM-DGHGSSVLIHPSS-----CLFGQELQLDWIIFHDVLVTSRVYVRTVCP 651

  Fly  1199 -------SMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLL 1256
                   .:||              :||:.| ::.|.|    :...::...||||..:.|..|..
Zfish   652 IRYDWVKDLLP--------------KLHEID-VYELSS----VAREEVTDEEMVQWEKKEAAKRQ 697

  Fly  1257 EEKIRDPCLNL 1267
            .|...|....|
Zfish   698 AEAREDAAKKL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	214/793 (27%)
		DEXDc	471..619	CDD:238005	61/152 (40%)
		HELICc	781..871	CDD:197757	32/89 (36%)
		HA2	948..1029	CDD:214852	24/85 (28%)
		OB_NTP_bind	1070..1212	CDD:285018	33/157 (21%)
dhx40	XP_021322026.1	HrpA	15..696	CDD:224557	224/842 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900