Protein Alignment CG1582 and DHX33

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_064547.2
• Gene: DHX33 / 56919
• HGNCID: 16718
• Length: 707
• Species: Homo sapiens
• Alignment Length: 855
• Identity: 237/855 - (27%)
• Similarity: 385/855 - (45%)
• Gaps: 193/855 - (22%)

  Fly   368 DTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSH-----YARGQTSRNDGGHQRNVEAQTREN 427
            :.:.||..||.    .|..|   |.:.....| |..     ...|...|..||.:|......:.:
Human     3 EEAGFPPAKRF----RPGSG---PPSRAGSFP-PGRQVVMLLTAGSGGRGGGGGRRQQPPLAQPS 59

  Fly   428 RRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD 492
            .....:.||.:           |:.||.|....::||.:.:....|:.||||.||:||:||::.:
Human    60 ASPYPEAVELQ-----------RRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYE 113

  Fly   493 NWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRL 557
            ...       :::.:    |..|||||::||.:|.||:.|:...:|:||||.:|.::..|:.||:
Human   114 GGI-------SRQGI----IAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRI 167

  Fly   558 SFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKD-----LKVILMSA 617
            .|.|.|:|||...||.||...:.||:||.|||:..:|.|..::|...:.||:     ||||:|||
Human   168 KFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSA 232

  Fly   618 TLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELE 682
            |::..|||.||.|||||.:.||..|:|..:                      .||.|.
Human   233 TMDVDLFSQYFNGAPVLYLEGRQHPIQVFY----------------------TKQPQN------- 268

  Fly   683 YADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSH 747
                                                              :.:.:.|..:.:...
Human   269 --------------------------------------------------DYLHAALVSVFQIHQ 283

  Fly   748 DWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILV-PLHSALSGEDQALVFKKAPPGKR 811
            :.|....||:||.|..||:::..:..|.|...|.....:|| ||:::|....|..||:.||.|.|
Human   284 EAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYR 348

  Fly   812 KIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGV 876
            |:::||||||||:||....:|||.|::|.|.::.:..:|.|.:..||:..|.||.|||||...|:
Human   349 KVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGI 413

  Fly   877 CIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGAL 941
            |..|||...:: ......||||||..|..::|::..::.   .|.|:  .:.:..|:.|.:..|:
Human   414 CYRLYTEDEFE-KFDKMTVPEIQRCNLASVMLQLLAMKV---PNVLT--FDFMSKPSPDHIQAAI 472

  Fly   942 TRLRDVGALDAEDQ---LTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVS 1003
            .:|..:|||:.:|.   |||:|..:||.|::.:..|.:|....|.|.:.:|||.:.||..|...:
Human   473 AQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHN 537

  Fly  1004 PLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLK 1068
            |.::|.|....::.|.....||:|:||.||.:      .|...::::..|:|::...:..:|:::
Human   538 PPSRREEVQGVRKKFISSEGDHMTLLNIYRTF------KNLGGNKDWCKENFVNSKNMTLVAEVR 596

  Fly  1069 YQYLELLVSIGFVPI-----DVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVK 1128
            .|..::.:.:. :||     ||...|:  |                        |..:|:.:..:
Human   597 AQLRDICLKMS-MPIASSRGDVESVRR--C------------------------LAHSLFMSTAE 634

  Fly  1129 IMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVF--QAPFLVFQEKVRTS 1191
            :. ||..|..|        .:|..          |.||||||     :|  :...:|:.|.:.|:
Human   635 LQ-PDGTYATT--------DTHQP----------VAIHPSSV-----LFHCKPACVVYTELLYTN 675

  Fly  1192 AIYIRDCSML 1201
            ..|:||..::
Human   676 KCYMRDLCVI 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661
		zf-CCCH	245..272	CDD:459885
		HrpA	452..>1075	CDD:441249	193/631 (31%)
		OB_NTP_bind	1114..1212	CDD:400182	21/90 (23%)
DHX33	NP_064547.2	Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019	1..80		20/95 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		14/68 (21%)
		HrpA	73..>700	CDD:441249	220/766 (29%)
		DEAH box	194..197		2/2 (100%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019	471..562		29/90 (32%)
		Critical for rDNA-binding. /evidence=ECO:0000250	547..558		1/10 (10%)