DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and dhx36

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001122016.2	Gene:	dhx36 / 569072	ZFINID:	ZDB-GENE-050419-20	Length:	1037	Species:	Danio rerio

Alignment Length:	1025	Identity:	373/1025 - (36%)
Similarity:	564/1025 - (55%)	Gaps:	162/1025 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGG--- 387
            |.|.|...|: .|::|         ..|..||.:.::..||   ...||..:|....:.|.|
Zfish    85 ERRSRAVVHM-DESRE---------KHITQLLNTVQRDLGR---DVHPSTSQSWRNKDEARGHSY 136

  Fly   388 --GVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTREN--RRLLQQFV------------E 436
              |.:|....:..|.|....:.:...:....:.:::.:..|.  ..|||..|            :
Zfish   137 FDGDDPVETQNIMPLPKVEPKDEKQEDAIKSRASLKEELNETNLEYLLQDVVQIPFLDEELKKDQ 201

  Fly   437 RRKEER--YQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRAL 499
            ::||:.  |.:::..||:||::...|.::.||.::.|:||||||||||:|||.|||||::..|
Zfish   202 QKKEDNAAYIEMLKFRKKLPSYGMREELVRLISANRVLVISGETGCGKTTQVTQFILDDFIQR-- 264

  Fly   500 QLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQ--LVGYQIRLENKVSQST-RLSFCT 561
               .:.:|  ..::||||||:|||.||||||.||.:.:|:  ..||||||::::.:.. .|.:||
Zfish   265 ---GQGSL--CRVVCTQPRRISAISVAERVAVERAEPVGEGKSCGYQIRLQSRLPRKQGSLLYCT 324

  Fly   562 TGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSD 626
            ||::|:.|.|||.|.|:||:::||:||||.:||.|:.|:|:||..|.||||:||||||||..||.
Zfish   325 TGVILQWLHSDPYLSSITHLVLDEIHERSVQSDILITIVKDLLTARDDLKVVLMSATLNAEKFSK 389

  Fly   627 YFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGE 691
            ||...|::.|||.||||.:..|||::|:..|...|..:.....|:...
Zfish   390 YFNNCPMIHIPGYTFPVTEYLLEDVVELLGFQPRYKQRKPHYRKRNNH----------------- 437

  Fly   692 APGKKIKDEKLTLAETYQR----YA-----EYSKPTCKSIYLM-EPMTINPELIESVLKYIVEGS 746
              |...:.||..:...|..    ||     .:|..|.:.:.:| :...|:.||..:::::|....
Zfish   438 --GSSARPEKGKIEAKYHESWPCYARTLRDRFSDTTIEVLGMMDDDDNIDLELTAALIRHIAVNE 500

  Fly   747 HDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQA-------LVFK 804
            :    ||.||:||||:..|.:::|.|:.:.:|.....:||::||||.:....|.       .|||
Zfish   501 N----EGAILVFLPGWDNISTLNDLLMSDQMFKSGRYRFIIIPLHSLMPTVSQTQVISLFPQVFK 561

  Fly   805 KAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRA 869
            |.|||.||||::|||||||:||||.|:|:|.|.:||..||:..|:.::...|||.||||||||||
Zfish   562 KPPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNIRTMTAEWVSIANAKQRKGRA 626

  Fly   870 GRVMPGVCIHLYTSYR------YQYHILAQPVPEIQRVPLEQIVLRIKTLQ-----TFASRNTLS 923
            |||.||.|.|||...|      ||       :|||||.|||::.|:||.|:     ||
Zfish   627 GRVSPGKCYHLYNGLRASLLDNYQ-------LPEIQRTPLEELCLQIKVLKLGPIATF------- 677

  Fly   924 VLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSV 988
             |.:|::.|::.::..|:|.|.|:.|||.:::|||||.|||.:||:..|||::|:||:..|||.|
Zfish   678 -LQKTMDPPSDRAIELAITHLVDLNALDRDEKLTPLGFHLARMPVEPHIGKMILFGALLGCLDPV 741

  Fly   989 LTIAACLSNKSPFVSPLNKRTEADKCKRMFALGN-SDHLTVLNAYRKWLDVARRGNYAASRNYAS 1052
            |||||.||.|.||..||.|...||:.::||:..: ||||:::||:..|.|..|||: ...|.|..
Zfish   742 LTIAASLSFKDPFFIPLGKEKIADQRRKMFSQNSRSDHLSIVNAFLGWEDAKRRGS-RFEREYCW 805

  Fly  1053 EHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSL 1117
            ::|||.|||:.:.::|.|:.|.|:..|||....|   |:...||          |.:|.:|:.::
Zfish   806 DNFLSANTLQMLQNMKGQFAEHLLRAGFVNSKDP---KDPSSNI----------NSENKKLVKAV 857

  Fly  1118 LCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHH-----DLRFKTRGDGYVKIHPSSVNSQVSVF 1177
            :.|.|||.:.||                 .|||:     .::..|:.||.|.|||.|||::.:.|
Zfish   858 IVAGLYPKVAKI-----------------SPSHNKKRPMPVKVYTKADGKVCIHPKSVNAEETQF 905

  Fly  1178 QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETA 1242
            |..:||:..|::|::|::.||:.:...:::.|.|:.......|.|.:.:.|  ||:.::.. ..|
Zfish   906 QYKWLVYHLKMKTTSIFLYDCTEVSPFSLLFFGGNISIQRDQDQDTIAVDE--WIVFQSPG-RIA 967

  Fly  1243 EMVQCLRAEMIKLLEEKIRDPCLNLLH-------HKNGCRMIANIVHLIS 1285
            .:|:.|:.|:..||||||:.|     |       ....|.:|:.|:.||:
Zfish   968 HLVKDLKKELDVLLEEKIKSP-----HPVDWKDQQSKDCAVISAIIDLIT 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440	9/33 (27%)
		HrpA	419..1206	CDD:224557	329/839 (39%)
		DEXDc	471..619	CDD:238005	81/150 (54%)
		HELICc	781..871	CDD:197757	51/96 (53%)
		HA2	948..1029	CDD:214852	44/81 (54%)
		OB_NTP_bind	1070..1212	CDD:285018	42/146 (29%)
dhx36	NP_001122016.2	HrpA	193..992	CDD:224557	343/882 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1595
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850