DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and ythdc2

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_021332046.1	Gene:	ythdc2 / 567114	-ID:	-	Length:	1381	Species:	Danio rerio

Alignment Length:	1072	Identity:	333/1072 - (31%)
Similarity:	496/1072 - (46%)	Gaps:	272/1072 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 PDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRL---LQQFVERRKEERYQKIIDGRKQ 452
            |.:...:|....|..||..|..|     ..::::|.:.||   :.|...||...  .::...||.
Zfish   125 PISSRERSQLQPHAERGLQSPPD-----TTDSKSRTSGRLSHGIPQVPPRRSSA--PELDAFRKA 182

  Fly   453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQP 517
            ||.:...|:|:..|....||::.||||.||:||:|||:||:  ..|...|.:       |.||||
Zfish   183 LPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDD--CSATASPCR-------IFCTQP 238

  Fly   518 RRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRL-ASDPLLGSVTHV 581
            |||:.|.|||||||||.:.|||.||||||||::||..|.|:|||:|:|||.| |.|..|.:||||
Zfish   239 RRLATIAVAERVAAERGENIGQTVGYQIRLESRVSPKTLLTFCTSGVLLRTLMAGDEALSTVTHV 303

  Fly   582 IVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQL 646
            ||||||||...:||||..:|.:|::..:|:::|.||.|:.:||..|||..||:.|.|..:.|:||
Zfish   304 IVDEVHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFGSCPVIHIKGCPYEVKQL 368

  Fly   647 FLEDILEMSDFVMEYDTKYCRKLKKQE------QEILERELEYAD---------------VQASG 690
            ||||||..:.:..:...||.::.:|:|      .|..||::..||               :...|
Zfish   369 FLEDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADPPERPTVCVLQDNQLLDDGG 433

  Fly   691 EAPGKKIKDEKLTLAE------------------------------------------------- 706
            ::...::.::.::..|
Zfish   434 DSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILNENISVDYRHSETSATAL 498

  Fly   707 ------------------------------TYQRYAEYSKPT----------------------- 718
                                          |...:|::.|.|
Zfish   499 MVSAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVDLLESHIWCAEASPQDEASL 563

  Fly   719 ---------CKSIYLM-------EPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQS 767
                     |:...|:       :...::.:||..:|..|.:.|.    :|.:||||||:.||.|
Zfish   564 LQNSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSSD----QGAVLIFLPGYDEIVS 624

  Fly   768 VHDSLL-DNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVF 831
            :.|.:| |:..|:....:|.:..|||::...||..|.|..|.|.|||:|||||||||:|:.|.||
Zfish   625 LRDQILFDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVRKIILSTNIAETSITVSDVVF 689

  Fly   832 VVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVP 896
            |:|.|.:|||.:|:..|:..|.:||:|:|:|.||||||||..||||.||::..|:. ::|...:|
Zfish   690 VIDSGKVKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFS-NMLEHQIP 753

  Fly   897 EIQRVPLEQIVLRIKTL-------QTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAED 954
            ::.|:||:::.|..|.|       ..|.||        ..|.|..::|..|:..|:.:.|:|..:
Zfish   754 QLLRMPLQELCLHTKLLAPINCPVAEFLSR--------APEPPHINTVKHAVQMLKTIDAMDPWE 810

  Fly   955 QLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLN--KRTEADKCKRM 1017
            .||.||.|||.|||:..:||::|...:.:|||.|||||..|:::.|||.|..  :|..|..|:|.
Zfish   811 NLTELGLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAMLCRRR 875

  Fly  1018 FALGN-SDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFV 1081
            |.... |||:.:|.|::.| ..||...:  .|.:..::|||..|:|.|..::.|.|..|.:.|||
Zfish   876 FTANTFSDHMALLRAFQAW-QKARSDGW--ERAFCEKNFLSQATMEIIVSMRTQLLGQLRATGFV 937

  Fly  1082 PIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPR 1146
                  |.:...|    :..|  |.|.:|..::.:.|.|.:|||::
Zfish   938 ------RARGGGD----IRDV--NQNSENWAVVKAALVAGMYPNLI------------------- 971

  Fly  1147 EPSHHD-LRFKTRGDGYVKIHPSSVNSQVSVFQAP---------------FLVFQEKVRTSAI-Y 1194
               |.| |......:..|::||:||.||....:.|               :|::.|..|...| .
Zfish   972 ---HRDGLSLSGEKEKKVRLHPTSVLSQPQYKKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIAS 1033

  Fly  1195 IRDCSMLPLIAMVLFAG---------------------SDFKVE-------LHDGDFLFLLESGW 1231
            :|.|:.:..:.:.||.|                     ||.:||       .|      |....|
Zfish  1034 VRCCTAVTPLTIALFGGGAKLPSSALQEAVLQRGSADSSDSEVEDQCSARQAH------LTLDHW 1092

  Fly  1232 IILKAHDLETAEMVQCLRAEMIKLLEEKIRDP 1263
            |..:. |.||||:|..||.....:...:||.|
Zfish  1093 INFRL-DPETAELVFGLRQRWQSVFLRRIRSP 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	304/957 (32%)
		DEXDc	471..619	CDD:238005	83/148 (56%)
		HELICc	781..871	CDD:197757	46/89 (52%)
		HA2	948..1029	CDD:214852	36/83 (43%)
		OB_NTP_bind	1070..1212	CDD:285018	37/179 (21%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077
		HrpA	169..>1001	CDD:224557	293/892 (33%)
		ANK repeat	496..524	CDD:293786	0/27 (0%)
		YTH	1248..1379	CDD:309322
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920