DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and tdrd9

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001123984.1	Gene:	tdrd9 / 553222	ZFINID:	ZDB-GENE-090313-193	Length:	1342	Species:	Danio rerio

Alignment Length:	919	Identity:	267/919 - (29%)
Similarity:	418/919 - (45%)	Gaps:	181/919 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 SHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALI 466
            |..:..:..::|.|:||...||...........:     ..|:..|     ||.....:.:::||
Zfish    48 SELSSPEKEKSDDGNQRRKRAQLPTGPGTSPPSL-----ASYEYPI-----LPITKNRQELVSLI 102

  Fly   467 ESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAA 531
            |::.||:|.|.||.||:||:||||||::        |:.|:| ..::.||||::.|.|:|..||.
Zfish   103 ENNSVVIIRGATGSGKTTQLPQFILDHY--------AERNIP-CNLVVTQPRKIGATGIARWVAR 158

  Fly   532 ERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFL 596
            ||...:|.|||||:.||...::.|:|.:.|||:||::|.|...|...:|:.:|||||||||.|||
Zfish   159 ERKCTLGSLVGYQVGLEKMATEHTKLIYVTTGVLLQKLVSSKTLTEYSHIFIDEVHERSEELDFL 223

  Fly   597 LLILKNLLRER-KDLKVILMSATLNAALFSDYFGG--------APVLDIPGRTFPVQQLFLEDIL 652
            ||:::.|||.. :.:||||||||:|...|::|||.        |.|.::.|..:.|::.:|:::.
Zfish   224 LLVVRKLLRSNSRYVKVILMSATINCIEFAEYFGSPIRNQMNPAYVFEVEGAPYAVEEYYLDELK 288

  Fly   653 EMSDFVMEYDTKYCRKLKKQEQEILERELEYAD--VQASGEAPGKKIKDEKLTLAETYQRYAEYS 715
            .|....:..|...     .|:..|.|.....|.  :|:..|...|..:..:.|
Zfish   289 TMLPVGVNLDLTL-----PQDPYITEEMYNVAVSLIQSFDEMEAKDHRRSEQT------------ 336

  Fly   716 KPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSP 780
                                         ||...|..|::|:||||..|||.:.::|  :.|...
Zfish   337 -----------------------------GSTTHPERGSVLVFLPGLAEIQYMKEAL--SKLVRK 370

  Fly   781 RAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDS 845
            |...:   ||||.::.|:|..||....||.|||:|||||||:|||:.|..:|:|..|:::...|.
Zfish   371 RLQVY---PLHSTVTLEEQNGVFLVPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLVRQLACDK 432

  Fly   846 NRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRI 910
            ..|...|.:.|.|:.:..||:||||||..|.|..|.|.:.::..|....:||:.|.||...:|::
Zfish   433 ETNYRCLRITWASKTSCNQRRGRAGRVSKGFCYRLVTRHFWENEIPNFSIPEMLRSPLASTLLKV 497

  Fly   911 KTLQTFASRNTLSVLLETLEAPTEDSVLGALTR----LRDVGALDAED--------QLTPLGHHL 963
            |.|.....|:.||..|       ...:||.:.|    |:.:|||..:.        .||.||..|
Zfish   498 KLLDMGDPRSVLSTAL-------TPPILGDIERTVLQLKQIGALSVQSNSQRQFDGDLTFLGRVL 555

  Fly   964 AALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALG-NSDHLT 1027
            |.||||:::|||::.|.:|.||:..|.|||.||.||.|..|..::....:.|..||.. .||.:.
Zfish   556 AQLPVDLQLGKLIVLGHVFGCLEECLIIAASLSLKSFFAMPSLQQLAGYRSKLSFAQNVPSDFIA 620

  Fly  1028 VLNAYRKWLDVARRGNYAASRN---YASEHFLSLNTLETIADL------KYQYLELLVSIGFVPI 1083
            .:||::.|.....:|.....::   :..|:.:.:..:..:|:|      :.....:.:|....|.
Zfish   621 YVNAFKAWYTSRAKGELRHPKDELEWGKENCIQIKRIREVAELFEDLKKRVSRFNMHISSSSNPT 685

  Fly  1084 DVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREP 1148
            |.....|                   ...:|..::..||:||   ..:...:..|.|.    :|.
Zfish   686 DYTSLHK-------------------QRFILQVVIAGALFPN---YFSQGEIDEQLAS----KEL 724

  Fly  1149 SHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSD 1213
            |.:|.:                 :.:.:...|...|....:..::: |.|..:..||   |.||.
Zfish   725 SGNDPK-----------------TTILIRNLPPFAFLCYKQLQSLF-RQCGQVKSIA---FDGSR 768

  Fly  1214 FKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNL-LHHKNGCRMI 1277
            ..||.|..   .:.|||.:    |::            ::.||..: ..|.|:| :||.:.....
Zfish   769 AYVEFHRS---CVRESGVL----HEV------------LLALLRSR-HTPALHLQVHHADEVEFH 813

  Fly  1278 AN---IVHL 1283
            |.   |.||
Zfish   814 AKGKPIAHL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	240/819 (29%)
		DEXDc	471..619	CDD:238005	73/148 (49%)
		HELICc	781..871	CDD:197757	38/89 (43%)
		HA2	948..1029	CDD:214852	35/89 (39%)
		OB_NTP_bind	1070..1212	CDD:285018	21/141 (15%)
tdrd9	NP_001123984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..81		7/32 (22%)
		DEXDc	84..262	CDD:214692	86/191 (45%)
		DEXDc	106..247	CDD:238005	73/149 (49%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	211..214		2/2 (100%)
		Helicase_C	343..459	CDD:278689	50/120 (42%)
		HA2	530..622	CDD:214852	35/91 (38%)
		TUDOR	851..972	CDD:278965
		TUDOR	905..954	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920