DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and dhx38

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_957170.1	Gene:	dhx38 / 393850	ZFINID:	ZDB-GENE-040426-1144	Length:	1258	Species:	Danio rerio

Alignment Length:	1345	Identity:	320/1345 - (23%)
Similarity:	535/1345 - (39%)	Gaps:	338/1345 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DESSRKHMEDCFLRSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLR----- 61
            :|..|||.:     ...|.|...|.|:.|...:.:|:|..:....|..|..|:...|...
Zfish   124 EEFKRKHQQ-----REKDRREHGVYASSKEDKSKDKNRSRDREHDRHRDRERRKDRDERESSRSR 183

  Fly    62 ------------QIHGPEFQLDDISKYKDRG----------------------------RGGHGV 86
                        .:.....|.:..|:...||                            .|....
Zfish   184 GSSSSRSERSEGSVRSERSQREGCSERMSRGTRREEPESPRNKPKDLATPSRCSWDEDDSGYASS 248

  Fly    87 KHSYWQDRGTLVVQSVQGVSSTRGND-------SDGDRLRRYALAKLENYGFQAVHCLEAYEHCS 144
            :||:|        :|.....|.|.||       |..|..||...:| ..|.........:|::..
Zfish   249 RHSHW--------ESPSPAPSHRENDRSERSQRSVRDSERRDRSSK-PQYPTDTPLPTPSYKYNE 304

  Fly   145 GDTEAALLLLYRRYMRIPDEEQLTLEPPSEQEILDMRADEKEALESIFDKAYEEREANRVWNLKF 209
            ...:........|..|...|::    ...|..|.....||||..|.      ::|:|:|.|   :
Zfish   305 WANDRKHFGSTPRLSRGKGEKR----EEGEGGIQFDDEDEKEQWEE------DQRQADRDW---Y 356

  Fly   210 RID-------HLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCR 267
            .:|       :.|..|..|..|.||.:|       |....|:.....|..|.|.:         |
Zfish   357 MMDEGYDEFHNPLTSSSDEYVKKREQIL-------QKQTQKRISAQKRQINEDNE---------R 405

  Fly   268 FAHLPQQPTESDTTKKDSVDEN---DNELWFHVEVR--FPPGSRYPYEAPFIYLKTTCHDIPHEL 327
            :.  ..:...|...::..|||:   ||....|:.|.  .||.    .:...::.|.....||
Zfish   406 WE--TNRMLTSGVVQRLEVDEDFEEDNAARVHLLVHNLVPPF----LDGRIVFTKQPEPVIP--- 461

  Fly   328 RLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPD 392
                       .|:...|       :..:.:...||..|                       :.:
Zfish   462 -----------VKDATSD-------MAIISRKGSQLVRR-----------------------HRE 485

  Fly   393 AEHHQSPKPSHY---------ARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEE------- 441
            .:..:..:..|:         ..|...:.|||..:.|....:.:.|..|:|.:..||:
Zfish   486 QKERKKAQHKHWELAGTKLGDIMGIQKKEDGGDSKAVGEDGKVDYRAEQKFADHMKEKSEASSDF 550

  Fly   442 -RYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKE 505
             :.:.:::.|:.||.||..:::|.:|..:.:|::.||||.||:||:.|::.::.:
Zfish   551 AKKKTLLEQRQYLPIFAVRQQLLNIIRDNNIVIVVGETGSGKTTQLTQYLHEDGY---------- 605

  Fly   506 NLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLA 570
             ..:..:.||||||::|:.||:||:.|....:|:.|||.||.|:..|:.|.:.:.|.|||||...
Zfish   606 -TSYGMVGCTQPRRVAAMSVAKRVSEEMNSNLGEEVGYAIRFEDCTSEKTMIKYMTDGILLRESL 669

  Fly   571 SDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLD 635
            .:..|...:.||:||.||||..:|.|..:|:.::..|.|||:|:.|||:::..|:.:||..|:..
Zfish   670 RESDLDHYSAVIMDEAHERSLNTDVLFGLLREVVSRRSDLKLIVTSATMDSDKFASFFGNVPIFH 734

  Fly   636 IPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDE 700
            ||||||||..||                      .|..||
Zfish   735 IPGRTFPVDILF----------------------SKTPQE------------------------- 752

  Fly   701 KLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEI 765
                                            :.:|:.:|..:: .|.....|.||||:||..:|
Zfish   753 --------------------------------DYVEAAVKQALQ-IHLSGMVGDILIFMPGQEDI 784

  Fly   766 QSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCV 830
            :...|.:::.......|....::|::|.|..:.||.:|:|||.|.||.:::|||||||:|:|..:
Zfish   785 EVTSDQIVERLADLENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIM 849

  Fly   831 FVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPV 895
            ||||.|..|.|.|:....|::|.:..:|:|||.||.|||||..||.|..|||...::..:|...:
Zfish   850 FVVDSGYCKLKVFNPRIGMDALQVYPISQANANQRAGRAGRTGPGQCYRLYTQSAFKNEMLTTTI 914

  Fly   896 PEIQRVPLEQIVLRIKTL--QTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTP 958
            |||||..|..:||.:|:|  |..       :|...::.|.||::|.::.:|..:||||....|||
Zfish   915 PEIQRTNLANVVLLLKSLGVQDL-------LLFHFMDPPPEDNMLNSMYQLWILGALDNTGALTP 972

  Fly   959 LGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNS 1023
            .|..:...|:|..:.|:::......|...:|.|.:.||..|.|..|..:..|:|:.:..|::..|
Zfish   973 TGRLMVEFPLDPALSKMLIVSCDMSCSADILIIVSMLSVPSIFYRPKGREEESDQVREKFSVPES 1037

  Fly  1024 DHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRR 1088
            ||||.||.|.:|    :..||  |..:.::||:....:..:.:::.|..:::|          ::
Zfish  1038 DHLTYLNVYLQW----KNNNY--SSIWCNDHFIHTKAMRKVREVRAQLKDIMV----------QQ 1086

  Fly  1089 RKN--ACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHH 1151
            :.|  :|              |.:..::...:|||.:....|:..... |:....|.    |.|
Zfish  1087 KMNLISC--------------GSDWDVIRKCICAAYFHQAAKLKGIGE-YVNVRTGM----PCH- 1131

  Fly  1152 DLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKV 1216
                         :||:|....:. :...::::.|.|.|:..|:: |        |.....::..
Zfish  1132 -------------LHPTSALFGMG-YTPDYIIYHELVMTTKEYMQ-C--------VTAVDGEWLA 1173

  Fly  1217 ELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIR 1261
            ||  |...:.::......:.:.....|.:..:..|| .|.:|:||
Zfish  1174 EL--GPMFYSIKHAGKSRQENRRRAKEEITNMEEEM-SLAQEQIR 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	3/30 (10%)
		zf-CCCH	250..272	CDD:279036	4/21 (19%)
		RWD	<284..360	CDD:283440	14/80 (18%)
		HrpA	419..1206	CDD:224557	223/798 (28%)
		DEXDc	471..619	CDD:238005	56/147 (38%)
		HELICc	781..871	CDD:197757	41/89 (46%)
		HA2	948..1029	CDD:214852	27/80 (34%)
		OB_NTP_bind	1070..1212	CDD:285018	22/143 (15%)
dhx38	NP_957170.1	DEXDc	557..744	CDD:214692	76/197 (39%)
		DEXDc	580..718	CDD:238005	56/148 (38%)
		HELICc	793..892	CDD:197757	43/98 (44%)
		HA2	961..1043	CDD:214852	27/81 (33%)
		OB_NTP_bind	1077..1177	CDD:285018	24/154 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910