DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx30

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006243888.1	Gene:	Dhx30 / 367172	RGDID:	1308888	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	291/875 - (33%)
Similarity:	440/875 - (50%)	Gaps:	136/875 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 ENRRLLQQFVE--RRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQ 488
            |..||.|..:|  ||:...:|:    ..|||.....:.||:.||..|||||||:|||||:|::||
  Rat   437 EEVRLSQSLLELWRRRGPIWQE----APQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQ 497

  Fly   489 FILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENK-VS 552
            .:|:.:.       .:.......:|.|||||:||:.||:||:.|....:.:.||:|:|||:| .:
  Rat   498 LLLERYV-------TEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPA 555

  Fly   553 QSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSA 617
            :...|.|||.|||||:|.|:|.|..|:||||||||||...:||||::||.|.|....|:::||||
  Rat   556 RGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 620

  Fly   618 TLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELE 682
            |.:...||.||||.||:.:||..:||::.:|||||              .||.|.:.....|..|
  Rat   621 TGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL--------------AKLGKHQYPHRHRHHE 671

  Fly   683 YADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYI-VEGS 746
                                            |:..|         .::.:|:..::.:| ..|
  Rat   672 --------------------------------SEDEC---------ALDLDLVTDLVLHIDARG- 694

  Fly   747 HDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKR 811
                ..|.||.||||:.||:.|...|.:  .......|::::|:||.:...||..:|::.|.|.|
  Rat   695 ----EPGGILCFLPGWQEIKGVQQRLQE--ALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVR 753

  Fly   812 KIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGV 876
            ||||:|||||||:|::|.|.|||.||.||:.:|....:..|:.|||||||..||:|||||...|.
  Rat   754 KIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGF 818

  Fly   877 CIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGAL 941
            ..||:...|.:..:..| ||||.|.|||.:||:.|.  ....:..:..|.:.:::|...:|..|:
  Rat   819 AYHLFPRSRLEKMVPFQ-VPEILRTPLENLVLQAKI--HMPEKTAVEFLSKAVDSPNIKAVDEAV 880

  Fly   942 TRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLN 1006
            ..|:::|.||..:.||.||..||.:..|.|:.|.::..|||:||..:|.:.:||: :.||.|.|.
  Rat   881 ILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ 944

  Fly  1007 KRTEADKCKRMFAL-GNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQ 1070
            .|.|.||.|.:.:. ..||||..:.|...|.:|.|..:..:..||..|:.|...:|..|..|..|
  Rat   945 NRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQ 1009

  Fly  1071 YLELLVSIGFV--PIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPD 1133
            :.|.:.....|  |.|        |    ||...:.|...:...|:..:|.|.||||:
  Rat  1010 FSENIYEAFLVGKPSD--------C----TLPSAQCNEYSEEEELVKGVLMAGLYPNL------- 1055

  Fly  1134 RVYIQTAGGAVPREPSH--HDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTS-AIYI 1195
               ||...|.|.|:...  :.:.::|: .|.:.:|.|::|.:.:..::.:|.:...|::: ::::
  Rat  1056 ---IQVRQGKVTRQGKFKPNSVTYRTK-SGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFV 1116

  Fly  1196 RDCSMLPLIAMVLFAGSDF---------KVELHDGDFLFLLESGWIILKAHDLETA--EMVQ-CL 1248
            ||.|.:..:|::|....|.         .:.|.|.|.|.|......:....:|..|  .||: .|
  Rat  1117 RDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSL 1181

  Fly  1249 RAE--------------MIKLLEEKIRDPC 1264
            |:|              ::.||.|.:|.||
  Rat  1182 RSELAALPLSVQQEHGQLLALLAELLRGPC 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	270/789 (34%)
		DEXDc	471..619	CDD:238005	72/148 (49%)
		HELICc	781..871	CDD:197757	45/89 (51%)
		HA2	948..1029	CDD:214852	33/81 (41%)
		OB_NTP_bind	1070..1212	CDD:285018	33/146 (23%)
Dhx30	XP_006243888.1	DEXDc	466..645	CDD:214692	88/185 (48%)
		DEXDc	480..621	CDD:238005	71/147 (48%)
		HELICc	714..813	CDD:197757	46/100 (46%)
		HA2	885..968	CDD:214852	33/83 (40%)
		OB_NTP_bind	1008..1130	CDD:285018	32/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820