DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx57

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001178836.1	Gene:	Dhx57 / 366532	RGDID:	1310340	Length:	1391	Species:	Rattus norvegicus

Alignment Length:	1352	Identity:	537/1352 - (39%)
Similarity:	768/1352 - (56%)	Gaps:	134/1352 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PKSQAADNKSR-----------KTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRG 82
            |......|||:           |..|..|.:..|:::.....||     :.|........:||..
  Rat    77 PSRPCDSNKSKGETRPKWKPKAKVPLQTLHMTSENQEKVKALLR-----DLQEQGADAGSERGSS 136

  Fly    83 G-------HGVKHSYWQDRGTLVVQSVQGVSST----------RGNDSDGDRLRRY-----ALAK 125
            |       .|.....|.          .|...|          .|.:.....|..:     |:.|
  Rat   137 GEEEEDAPEGAAEQSWS----------AGPEPTFLPDCRPWEYIGPEEVEPPLPEFTVSPLAVQK 191

  Fly   126 LENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPP----SEQEILDMRADEKE 186
            |..|||...||..|...|.||..|||..|..:.......|::.|...    |..|.::.|.:|..
  Rat   192 LSRYGFHTEHCQLALRICEGDLGAALEHLLHQCFSETFGERMALSEAAVSVSLDECVEQRQEETL 256

  Fly   187 ALESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRC 251
            ||:||..:.:.||..||||.:...:::|    .::..|:::         .::..:.:...|..|
  Rat   257 ALKSICGEKFIERIQNRVWTIGLELEYL----TNKFCKSKQ---------KESNKNVRDTSPETC 308

  Fly   252 RNFDRDGTCKYGPKCRFAH--LPQQ---PTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEA 311
            : |...|.||:|.||:|.|  .|.|   .||.:........|||....:.:::||....:|||:|
  Rat   309 K-FYLKGNCKFGSKCKFKHEVPPHQIIGRTERNVNDPHLDAENDTTFLYELQIRFSKDHKYPYQA 372

  Fly   312 PFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAF---- 372
            |.:...:|..::|...||..:..||.:|.|..:...|.|||:..||:...::...|..:..
  Rat   373 PLVAFYSTNENLPLACRLHISEFLYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSV 437

  Fly   373 ------PSPKRSLF----YDEPA-------------GGGVN---PDAEHHQSPKP-----SHYAR 406
                  |:|..:..    |.:|.             |.|::   .||:..:.|.|     ..|.
  Rat   438 PPINVPPAPSETRISKPAYRKPVIPSNTFLSNQMLEGEGLSELEEDADEDEGPAPIVVENESYV- 501

  Fly   407 GQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPV 471
            ....|:.....|..::...||.::.:||..::...::..|:..|:.|||:.|.|.||.|:....|
  Rat   502 NLKKRSYRRCDRPAKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQV 566

  Fly   472 VVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDR 536
            |||||.|||||:||:|||||||    :|..|.:.   ...||||||||:|||.||||||.||.:|
  Rat   567 VVISGMTGCGKTTQIPQFILDN----SLNGPPER---VANIICTQPRRISAISVAERVAKERAER 624

  Fly   537 IGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILK 601
            :|..||||||||:..|.:|||.:||||:|||||..|..|..|||:||||||||:||||||||:||
  Rat   625 VGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLK 689

  Fly   602 NLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYC 666
            :::.:|..|:||||||||:|.|||.||...||:.||||.|||.|.||||.|.::.:|::..:.|.
  Rat   690 DIVMQRATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYM 754

  Fly   667 RKLKKQEQEIL------------ERELEYA-DVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPT 718
            |.:|:..:|.|            |.:|..| .:|...|:....|.|::|...:...||...||..
  Rat   755 RSMKQIAKERLKARHNRTALEEVEEDLRLALHLQDEEESVKDTIPDQQLDFKQLLVRYKGVSKSV 819

  Fly   719 CKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALF-SPRA 782
            .|::.:|:...:|.||||::|::||:|.|.:| .|.||:||||..||:.:::.|..|:|| :.|:
  Rat   820 IKTMSVMDFEKVNLELIEALLEWIVDGKHSYP-PGAILVFLPGLAEIKMLYEQLQSNSLFNNRRS 883

  Fly   783 GKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNR 847
            .:.::.||||:||.|:|..||.|.|.|..||::||||||||:||||.|:|:|.|.||||.:|:.:
  Rat   884 HRCVIHPLHSSLSSEEQQAVFVKPPLGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGK 948

  Fly   848 NMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKT 912
            .||||:..:||:|||.|||||||||..|||.||:||:.|.:.:|.|.:||||||||||:.||||.
  Rat   949 GMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKI 1013

  Fly   913 LQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLML 977
            |:.|::.|..||....:|.|..||:..:..||||:|||..:::|||||:|||:||||||||||||
  Rat  1014 LEMFSTHNLQSVFSRLIEPPHVDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLML 1078

  Fly   978 YGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRG 1042
            .|:||:|||..|||||.|:.|||||||.:|:.||::.|..||..|||:|.:|.||:.| .::.:.
  Rat  1079 LGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGW-QLSTKE 1142

  Fly  1043 NYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVP----RRRKNACDNILTLTGVE 1103
            :..||.||..::|||..||:.:|.||.|:.|||..||||...:.    .:|....|.:|..||.|
  Rat  1143 SARASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEE 1207

  Fly  1104 QNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPS 1168
            .|.|.:|.:|::::||||||||:|::.||:..:.:|:.|.|..:|...:|:|.|:.||||.||||
  Rat  1208 ANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPS 1272

  Fly  1169 SVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWII 1233
            |||.||..|.:|:|::.||::||.::||||||:.:..:|||.|....|:|..|.|:..|:.|||.
  Rat  1273 SVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVSVQLQRGAFVVSLDDGWIR 1337

  Fly  1234 LKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLLHHKNGCRMIANIVHLIS 1285
            ..|...:.||:|:.||.|:.:||::||::|.::|.....|.|:|:.||.||:
  Rat  1338 FVAASHQVAELVKELRCELDQLLQDKIKNPSMDLCTCPRGSRIISMIVKLIT 1389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	14/30 (47%)
		zf-CCCH	250..272	CDD:279036	10/23 (43%)
		RWD	<284..360	CDD:283440	24/75 (32%)
		HrpA	419..1206	CDD:224557	398/804 (50%)
		DEXDc	471..619	CDD:238005	95/147 (65%)
		HELICc	781..871	CDD:197757	52/89 (58%)
		HA2	948..1029	CDD:214852	52/80 (65%)
		OB_NTP_bind	1070..1212	CDD:285018	65/145 (45%)
Dhx57	NP_001178836.1	UBA_DHX57	184..221	CDD:270502	15/36 (42%)
		RWD	249..422	CDD:399058	53/186 (28%)
		zf_CCCH_4	308..326	CDD:408151	9/18 (50%)
		HrpA	504..1301	CDD:224557	395/805 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349112
Domainoid	1	1.000	185	1.000	Domainoid score	I3311
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56267
Inparanoid	1	1.050	873	1.000	Inparanoid score	I391
OMA	1	1.010	-	-		QHG47570
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		oto96584
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910