DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx35

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006235485.1	Gene:	Dhx35 / 362260	RGDID:	1311165	Length:	703	Species:	Rattus norvegicus

Alignment Length:	829	Identity:	239/829 - (28%)
Similarity:	384/829 - (46%)	Gaps:	196/829 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 RKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWFFRALQLPAKENLPHVEII 513
            |::||.|.....||.|:|:...|||.|||||||||||||::.: .|       .|:..:..|
  Rat    51 RQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGW-------TAEGRVVGV--- 105

  Fly   514 CTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQ-STRLSFCTTGILLRRLASDPLLGS 577
             |||||::|:.||.|||.||...:|..|||.||.::.... :||:.|.|.|:|:|.:..||||..
  Rat   106 -TQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTK 169

  Fly   578 VTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFG----------GAP 632
            .:.|::||.|||:..:|..:.:||.:.::|.||::|:.||||:|..|.|:|.          ...
  Rat   170 YSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCV 234

  Fly   633 VLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKI 697
            :|.:.||||||      ||
  Rat   235 ILTVEGRTFPV------DI---------------------------------------------- 247

  Fly   698 KDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGF 762
                                    .||..|:   |:.|::.:..:|: .|....:|.||.||.|.
  Rat   248 ------------------------FYLQSPV---PDYIKATVDTVVK-IHQTEGDGDILAFLTGQ 284

  Fly   763 GEIQSVHDSLLDNALFSPRAG--KFI-LVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSV 824
            .|:::|...|::.|....|.|  |.: ::|:::.|...:|..||::.....||::::||:||||:
  Rat   285 EEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSI 349

  Fly   825 TIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYH 889
            ||...|:|:|||.||.:.::....:|.|.:|.||:|:|.||.||.||...|.|..|||...:: .
  Rat   350 TISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFE-Q 413

  Fly   890 ILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVL-LETLEAPTEDSVLGALTRLRDVGALDAE 953
            :....|||:||..|..:||::|.|      ...||| ...:..|...|::.||..|..:|.||.:
  Rat   414 LPQSTVPEMQRSNLAPVVLQLKAL------GIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKD 472

  Fly   954 DQLT-PLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRM 1017
            .:|| |||..:|..|::....|::|....|.|...:|:|||.:..::.||.|.|::::|.:..|.
  Rat   473 CRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRK 537

  Fly  1018 FALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVP 1082
            ||:...||||:||.|..::      .:..|..:..||||:...|...|.::.|..:|||.
  Rat   538 FAVEEGDHLTMLNVYEAFI------KHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVK----- 591

  Fly  1083 IDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPRE 1147
            ..||:                .:..||.:.:|..:: :..:.|..:.
  Rat   592 FQVPK----------------MSSEGDPDPVLRCIV-SGFFANAARF------------------ 621

  Fly  1148 PSHHDLRFKT-RGDGYVKIHPSSVNSQVSVFQAP-FLVFQEKVRTSAIYIRDCSMLPLIAMVLFA 1210
              |....::| |.|..:.|||:||   :...:.| ::::.|.::||..|:||.:
  Rat   622 --HSTGAYRTIRDDHELHIHPASV---LYAEKPPRWVIYNEVIQTSKYYMRDVT----------- 670

  Fly  1211 GSDFKVELHDGDFLFLLESGWII-LKAHDLETAEMVQCLRAEMIKLLEE 1258
                           .:||.|:: |..|..:....:. |:|:..|:.::
  Rat   671 ---------------AIESAWLLELAPHFYQQGTHLS-LKAKRAKVQDQ 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	231/774 (30%)
		DEXDc	471..619	CDD:238005	64/149 (43%)
		HELICc	781..871	CDD:197757	36/92 (39%)
		HA2	948..1029	CDD:214852	30/81 (37%)
		OB_NTP_bind	1070..1212	CDD:285018	26/143 (18%)
Dhx35	XP_006235485.1	DEXDc	53..224	CDD:214692	77/181 (43%)
		DEXDc	73..211	CDD:238005	64/148 (43%)
		HELICc	301..396	CDD:197757	36/94 (38%)
		HA2	465..549	CDD:214852	30/83 (36%)
		OB_NTP_bind	584..683	CDD:285018	30/169 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810