DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx15

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	900	Identity:	249/900 - (27%)
Similarity:	399/900 - (44%)	Gaps:	197/900 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 KRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKE 440
            ||.:...|..|.....|.|...|...:  |.|..::..||...|.:..|      :.........
  Fly     3 KRRIEVGETYGSKAKKDPEASSSSAAA--AAGTVAQILGGFVPNKQPPT------MNPLTNTPYS 59

  Fly   441 ERYQKIIDGRKQLPAF---AEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLP 502
            :|||.:...|..||.|   |:..|:|:|.:   .:|:.||||.||:||:||:.:|    .|:...
  Fly    60 QRYQNLYKKRIALPVFEYQADFMRLLSLHQ---CIVLVGETGSGKTTQIPQWCVD----FAVSKG 117

  Fly   503 AKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLR 567
            .|      .:.||||||::|:.||:||:.|...::|:.|||.||.|:..:..|.|.:.|.|:|||
  Fly   118 RK------GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLR 176

  Fly   568 RLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAP 632
            ...|||:|.....:::||.|||:..:|.|:.:||.::|:|.|||:::|||||:|..|..||..||
  Fly   177 EAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAP 241

  Fly   633 VLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKI 697
            ::.:||||.||:..:..:                     .|::.||..:.
  Fly   242 LMKVPGRTHPVEIFYTPE---------------------PERDYLEAAIR--------------- 270

  Fly   698 KDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGF 762
                                |...|::.|.:                       ||.||:||.|.
  Fly   271 --------------------TVIQIHMCEEI-----------------------EGDILMFLTGQ 292

  Fly   763 GEIQSVHDSL---LDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGK------RKIVLSTN 818
            .||:.....:   :||  .....|:...:||:|.|....|..:|:.|||..      ||:|:|||
  Fly   293 EEIEEACKRIKREIDN--LGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTN 355

  Fly   819 IAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTS 883
            |||||:|||..|||:|.|..|:|.::....:|||.:..:|:|:|:||.|||||..||.|..|||.
  Fly   356 IAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTE 420

  Fly   884 YRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVG 948
            ..::..:.....|||.|..|..:||::|.|    ..:.| |..:.::.|..::::.||..|..:.
  Fly   421 KAFKNEMQDNTYPEILRSNLGTVVLQLKKL----GIDDL-VHFDFMDPPAPETLMRALELLNYLA 480

  Fly   949 ALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADK 1013
            |||.:..||.||..::..|:|.::.|:::......|.:.:|:|.|.||....||.|...:..||:
  Fly   481 ALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADE 545

  Fly  1014 CKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSI 1078
            .|..||..:.||||:||.|..:...:.      ..|:..|:|::..:|::..:::.|...::...
  Fly   546 AKMRFAHIDGDHLTLLNVYHAFKQSSE------DPNWCYENFINFRSLKSADNVRQQLARIMDRF 604

  Fly  1079 GFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGA 1143
            ..                              .|..|.......|.||.|.:. ...::|.|
  Fly   605 NL------------------------------RRTSTEFTSKDYYVNIRKALV-QGFFMQVA--- 635

  Fly  1144 VPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVL 1208
             ..|.:.:.|..|...:  |::|||:....    :..::::.|.|.|:..|||..
  Fly   636 -HLERTGYYLTIKDNQN--VQLHPSTCLDH----KPDWVIYNEFVLTTKNYIRTV---------- 683

  Fly  1209 FAGSDFKVELHDGDFLFLLESGWIILKA---HDLETAEMVQCLRAEMIKLLEEKI 1260
               :|.|.|             |:...|   :||.  ...||.....::||::::
  Fly   684 ---TDVKPE-------------WLCCLAPQYYDLN--NFPQCEAKRQLELLQQRL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	227/798 (28%)
		DEXDc	471..619	CDD:238005	61/147 (41%)
		HELICc	781..871	CDD:197757	42/95 (44%)
		HA2	948..1029	CDD:214852	28/80 (35%)
		OB_NTP_bind	1070..1212	CDD:285018	22/141 (16%)
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/54 (31%)
		DEXDc	67..255	CDD:214692	83/200 (42%)
		DEXDc	91..228	CDD:238005	61/146 (42%)
		HELICc	315..408	CDD:197757	41/92 (45%)
		HA2	478..561	CDD:214852	28/82 (34%)
		OB_NTP_bind	595..698	CDD:285018	27/169 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840