DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and CG3225

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	221/762 - (29%)
Similarity:	349/762 - (45%)	Gaps:	161/762 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 IIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWFFRALQLPAKENLPH 509
            :::.|::||.....::||..:|...||::.||||.||||||||::.: .|..:.|
  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGL---------- 94

  Fly   510 VEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPL 574
              |..|:|||:|.:.:|.|||.||.:.:|..|||.:|....:|..|::.|.|.|||||.:.:|||
  Fly    95 --IGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPL 157

  Fly   575 LGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYF---GGAPV--- 633
            |.....:||||.|||:..:|.:|.:||.:||:|..||:|:.|||::|:.||::|   |...|
  Fly   158 LTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVK 222

  Fly   634 LDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIK 698
            |.|.||..||...:|.:              .|
  Fly   223 LSIEGRMHPVSNFYLNE--------------PC-------------------------------- 241

  Fly   699 DEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFG 763
                         |:|.|.|.::::.:                     |.....|.||.||.|..
  Fly   242 -------------ADYVKETVETVWKL---------------------HQKEPPGDILAFLTGQE 272

  Fly   764 EIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDD 828
            |:....| ||...:.|.......::|::.::|..||..||...|.|.||:||:|||||||:||..
  Fly   273 EVLEALD-LLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPG 336

  Fly   829 CVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQ 893
            .|:|:|||.:|.|.::.....:||.:|.||:|:|.||.|||||:.||....|||...|:.....|
  Fly   337 IVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQ 401

  Fly   894 PVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLT- 957
            | ||::|..|...:|::|.|   ...|.|.  .:....|...::|.||..|..:.|:|.:..||
  Fly   402 P-PEMRRSELSGAILQLKAL---GIGNILR--FDFPSPPPAQNLLSALESLFALDAIDEQGNLTK 460

  Fly   958 PLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADK--CKRMFAL 1020
            |:|:.||.||....:.|::.......|.:.::||.|.|..:|.|..|.:...:...  ..|.|.:
  Fly   461 PVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEV 525

  Fly  1021 GNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDV 1085
            ...|.:|:||||..:::      ...::.:..::||....|:....|:    |.|:::......:
  Fly   526 AEGDFITMLNAYTGFVE------EGMTKEFCGQYFLIYRNLKRAHSLR----EQLITVARKKYGI 580

  Fly  1086 PRRRKNACDNILTLTG-VEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPS 1149
            |         |.:..| ||:             ||..:                |||........
  Fly   581 P---------IFSCKGDVEK-------------LCKCI----------------TAGFFTQVAYL 607

  Fly  1150 HHDLRFKTRGDG-YVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYI 1195
            ||...::....| .:.|||:|  :..::.||.::|:.|.::|:.:::
  Fly   608 HHSGVYRQISSGTELAIHPNS--TLYTLPQAQYVVYGELLQTTKLFM 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	221/762 (29%)
		DEXDc	471..619	CDD:238005	65/148 (44%)
		HELICc	781..871	CDD:197757	40/89 (45%)
		HA2	948..1029	CDD:214852	23/83 (28%)
		OB_NTP_bind	1070..1212	CDD:285018	24/128 (19%)
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	221/762 (29%)
		DEXDc	64..202	CDD:238005	65/149 (44%)
		HELICc	289..380	CDD:197757	41/90 (46%)
		HA2	448..534	CDD:214852	23/85 (27%)
		OB_NTP_bind	<581..670	CDD:285018	22/112 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840