DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and CG8915

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	1018	Identity:	305/1018 - (29%)
Similarity:	472/1018 - (46%)	Gaps:	221/1018 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 DLLQSNE---QLAG----------RL-------DTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSP 399
            |.|||.|   ||.|          ||       ..|..|...|.||...|            ||.
  Fly    75 DFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEENRVLFISRP------------QSD 127

  Fly   400 KPSHYARGQTSRND--------GGHQRNVEAQTRENRRLL----------QQFVERR-------- 438
            ....|....|..:.        |....|||      |||:          ||:.:.|
  Fly   128 GQQQYILCNTKLDICPPLLDVLGQMAGNVE------RRLMNSVGDLKCNKQQYKDIRLPSNFGLV 186

  Fly   439 --------KEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWF 495
                    :..|.:.|...|:.||.:.:.|.||.:::...|::|.|.||.|||||:||:||: |
  Fly   187 GQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE-W- 249

  Fly   496 FRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFC 560
                   |.|:...|.|:.:||||::||.|:||::.||.:..|..|||.||:..:.|.:|.|...
  Fly   250 -------AAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307

  Fly   561 TTGILLRRLASD--PLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAAL 623
            |:|.|||.||.|  ....:.||:|:||.|||..::|||||..|..|::...|:::|||||::...
  Fly   308 TSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEA 372

  Fly   624 FSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQA 688
            .|:||||..|:|:.||:|.|....|||||..:.::.....|:.
  Fly   373 LSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFL---------------------- 415

  Fly   689 SGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIV-EGSHDWPRE 752
             |:..||:...|.|.        |.|...|     ::.| .|:.:||.|:|:.:: :|.     .
  Fly   416 -GKPTGKETPSELLA--------AYYGGNT-----IVHP-DIDNDLIVSLLELLLRQGD-----A 460

  Fly   753 GTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLST 817
            |.::::|||:.::.|:. :.|:::|  ||. :..::.|||.:...:|..||:..|..:.||:|||
  Fly   461 GAVIVYLPGYSDMTSLL-ARLESSL--PRE-QITIILLHSQVDNSEQRKVFRTYPGVRLKIILST 521

  Fly   818 NIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYT 882
            ||.:||:||.|.::|:|.||.|.|.:||..:...|.|.|:|:|:||||.||||||..|.|..||.
  Fly   522 NIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYD 586

  Fly   883 SYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFAS-RNTLSVLLETLEAPTEDSVLGALTRLRD 946
            :.| ...:....:|||.|..|::|.|..|....... .|.|::.|:|   |.:|:|:.:.:||:.
  Fly   587 NDR-MARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDT---PPKDAVMQSCSRLKL 647

  Fly   947 VGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNK-RTE 1010
            :|.||..|::|||||.:|.||:.|:|||.::|....:||||::.|||..|.:.|||..:.: :..
  Fly   648 LGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKS 712

  Fly  1011 ADKCKRMFALGN--SDHLTVLNAYRKWLDVARR--GNYAASRNY----ASEHFLSLNTLETIADL 1067
            ..:..|:...|:  ||.|.|:..|.::.::.|:  |:: ..||:    |.|.|:|  ...|:.|.
  Fly   713 GQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDF-CERNFICRNAMEMFVS--AASTLRDT 774

  Fly  1068 KYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTP 1132
            .|:..               |...|...:.:      :.|.|.| ::...|.|.|||   |:...
  Fly   775 VYRIF---------------RFSEASARLAS------SFNNDTN-MIRLALTAGLYP---KLAYM 814

  Fly  1133 DRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSV---NSQVSVFQAPFLVFQEKVRTS--A 1192
            ||               .:..:....||..|::..||.   ..:.....:.:::|.||.||:  .
  Fly   815 DR---------------ENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQI 864

  Fly  1193 IYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKA--------H------DLETAE 1243
            ..:...:::..:.:.|..|..|..|.|..:.|..|:| ||.||.        |      |.|.|:
  Fly   865 SSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDS-WIRLKCPAEFGLQLHKVRMLTDREFAK 928

  Fly  1244 MVQCLRAEMI----------KLLEEKIRDPCL----NLLHHKN 1272
            :|...:..::          :|||..:...||    :||...|
  Fly   929 LVATRKLSLMSDFIGPETVRRLLEADVPSTCLAEGKSLLDRDN 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440	3/4 (75%)
		HrpA	419..1206	CDD:224557	259/830 (31%)
		DEXDc	471..619	CDD:238005	67/149 (45%)
		HELICc	781..871	CDD:197757	40/89 (45%)
		HA2	948..1029	CDD:214852	33/83 (40%)
		OB_NTP_bind	1070..1212	CDD:285018	24/146 (16%)
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	15/47 (32%)
		DEXDc	214..395	CDD:214692	82/189 (43%)
		DEXDc	226..368	CDD:238005	67/150 (45%)
		HELICc	479..575	CDD:197757	43/98 (44%)
		HA2	648..733	CDD:214852	33/84 (39%)
		OB_NTP_bind	783..884	CDD:285018	23/125 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12832at50557
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850