DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and l(1)G0007

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	1273	Identity:	320/1273 - (25%)
Similarity:	503/1273 - (39%)	Gaps:	377/1273 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESSRKHMEDCFLRSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLRQIHGPE 67
            |..|:|::....|.|           ..|.||:.:.|..:....|..|..|....|..|:.|
  Fly   133 ERLREHIQRDRKRGP-----------VSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQH--- 183

  Fly    68 FQLDDISKYKDRGRGGHGVKHSYWQDRG-------TLVVQSVQ-------------GVSSTRGND 112
                     ::|.|..|   .|:.:|||       ::..:||.             |:|::..:|
  Fly   184 ---------RERERDRH---RSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDD 236

  Fly   113 SDGD---RLRRYALAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPPSE 174
            .||:   |...:.:.....:|           :.|||.........|.:.|..|    |:.|...
  Fly   237 EDGEFGQRKSDWDMPTPRRHG-----------NKSGDWSVRSGGSRRNHGRQDD----TVRPTPA 286

  Fly   175 QEILDMRADEK--------EALESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLA 231
            ..........|        |..||:.....|:|..:|.|   :.||
  Fly   287 HRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREW---YNID------------------- 329

  Fly   232 AAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDE----NDNE 292
                                ..:|.:.....||...:....::..|...||:.|..:    .|||
  Fly   330 --------------------EGYDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNE 374

  Fly   293 LWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLL 357
            ||                                           |...:...|:..:.|:.|
  Fly   375 LW-------------------------------------------ERNRMLTSGVVTLISVND-- 394

  Fly   358 QSNEQ----------------LAGRLDTSAFPSP----------------KRSLF---YDEPAGG 387
            ..:|:                |.||:..:..|.|                |.|..   |.|
  Fly   395 DFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYRE---- 455

  Fly   388 GVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVE--------AQTRENRRLLQQFVERRKEE--- 441
                ..|..::.|......|....|..|.||..:        .:.:.:.|..|:|.:..:::
  Fly   456 ----QKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTG 516

  Fly   442 ------RYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQ 500
                  |.:.|.:.|:.||.||..:.:|.:|..:.|::|.||||.||:||:.|::.::.:
  Fly   517 GKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGY----- 576

  Fly   501 LPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGIL 565
              :|..:    |.||||||::|:.||:||:.|...::|:.|||.||.|:..|:.|.:.:.|.|||
  Fly   577 --SKRGM----IGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGIL 635

  Fly   566 LRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGG 630
            ||....||.|.|.:.:|:||.||||..:|.|..:|:.::..|.|||:|:.|||::::.|:.:||.
  Fly   636 LRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGN 700

  Fly   631 APVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGK 695
            .|...||||||||..:|
  Fly   701 VPTFTIPGRTFPVDVMF------------------------------------------------ 717

  Fly   696 KIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLP 760
                               ||.||:            :.:||.:|..:: .|..|.||.:|||:|
  Fly   718 -------------------SKNTCE------------DYVESAVKQALQ-VHLTPNEGDMLIFMP 750

  Fly   761 GFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVT 825
            |..:|:...:.|.:.......|....::|::|.|..:.||.:|:|:..|.||.|::|||||||:|
  Fly   751 GQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLT 815

  Fly   826 IDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHI 890
            :|..::|:|.|..|.|.::....|::|.:..:|:|||.||.|||||..||....|||..:|:..:
  Fly   816 VDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDEL 880

  Fly   891 LAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVL-LETLEAPTEDSVLGALTRLRDVGALDAED 954
            ||..||||||..|...||.:|:|      ..:.:| ...::.|.:|::|.:|.:|..:||||...
  Fly   881 LALTVPEIQRTNLANTVLLLKSL------GVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTG 939

  Fly   955 QLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFA 1019
            .||.||..:|..|:|....::::......|...||.|.:.||..|.|..|..:..|||..:..|.
  Fly   940 ALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQ 1004

  Fly  1020 LGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELL-------VS 1077
            ...|||||.||.|::|    |:.||  |..:.:|||:.:..:..:.:::.|..:::       :|
  Fly  1005 RPESDHLTYLNVYQQW----RQNNY--SSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVIS 1063

  Fly  1078 IGFVPIDVPRRRKNACD----NILTLTGVEQNHNGDNNRLLTSLLC-----AALY-----PNIV- 1127
            .|   ||....||..|.    ....|.|:     |:...|.|.:.|     :|||     |:.|
  Fly  1064 CG---IDWDIVRKCICSAYFYQAARLKGI-----GEYVNLRTGMPCHLHPTSALYGLGTTPDYVV 1120

  Fly  1128 ---KIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY 1162
               .|||. :.|:|.|                |..|||
  Fly  1121 YHELIMTA-KEYMQCA----------------TAVDGY 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	4/30 (13%)
		zf-CCCH	250..272	CDD:279036	3/21 (14%)
		RWD	<284..360	CDD:283440	10/79 (13%)
		HrpA	419..1206	CDD:224557	238/787 (30%)
		DEXDc	471..619	CDD:238005	61/147 (41%)
		HELICc	781..871	CDD:197757	37/89 (42%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	29/118 (25%)
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	81/196 (41%)
		DEXDc	551..689	CDD:238005	61/148 (41%)
		HELICc	722..870	CDD:238034	56/160 (35%)
		HA2	932..1014	CDD:214852	29/81 (36%)
		OB_NTP_bind	1048..1148	CDD:285018	29/119 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840