DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1582 and dhx15

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001108613.1	Gene:	dhx15 / 321931	ZFINID:	ZDB-GENE-030131-650	Length:	769	Species:	Danio rerio

Alignment Length:	894	Identity:	253/894 - (28%)
Similarity:	393/894 - (43%)	Gaps:	221/894 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 AGGGVNP--DAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKII 447
            :|.|:.|  .|..||...|                                |.......||.:|:
Zfish    73 SGSGILPLKQASMHQQINP--------------------------------FTNLPHTPRYYEIL 105

  Fly   448 DGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEI 512
            ..|.|||.:...||...::......|:.||||.||:||:||:.:|  ..|:|..|.:      .:
Zfish   106 KKRLQLPVWEYKERFNDILNRHQSFVLVGETGSGKTTQIPQWCVD--MVRSLPGPKR------GV 162

  Fly   513 ICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGS 577
            .||||||::|:.||:|||.|....:||.|||.||.|:..|..|.|.:.|.|:|||...:||||..
Zfish   163 ACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLER 227

  Fly   578 VTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFP 642
            ...:|:||.|||:..:|.|:.:||.::|:|.|||||:|||||:|..|..||...|:|.|||||.|
Zfish   228 YGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQVYFDNCPLLTIPGRTHP 292

  Fly   643 VQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAET 707
            | ::|
Zfish   293 V-EIF------------------------------------------------------------ 296

  Fly   708 YQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSL 772
                           |..||   ..:.:|:.::.:::.......||.:|:||.|..||......:
Zfish   297 ---------------YTPEP---ERDYLEAAIRTVIQIHMCEEDEGDVLLFLTGQEEIDEACKRI 343

  Fly   773 ---LDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGK------RKIVLSTNIAETSVTIDD 828
               :|:  ..|..|...::||:|.|..:.|..:|:..||.|      ||:|:||||||||:|||.
Zfish   344 KREIDD--LGPDVGDIKIIPLYSTLPPQQQQRIFEPPPPRKPNGAIGRKVVVSTNIAETSLTIDG 406

  Fly   829 CVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQ 893
            .|||:|.|..|:|.::....:|||.:..:|:|:|:||.|||||..||.|..|||...|:..:...
Zfish   407 VVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDN 471

  Fly   894 PVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTP 958
            ..|||.|..|..:||::|.|    ..:.| |..:.::.|..::::.||..|..:.||:.:..||.
Zfish   472 TYPEILRSNLGSVVLQLKKL----GIDDL-VHFDFMDPPAPETLMRALELLNYLAALNDDGDLTE 531

  Fly   959 LGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNS 1023
            ||..:|..|:|.::.|:::....|.|.:.||:|.|.||....||.|...:..||:.|..||..:.
Zfish   532 LGSMMAEFPLDPQLAKMVIASCDFNCSNEVLSITAMLSVPQCFVRPTEAKKAADESKMRFAHIDG 596

  Fly  1024 DHLTVLNAYRKWLDVARRGNYAASRNYAS-----EHFLSLNTLETIADLKYQYLELLVSIGFVPI 1083
            ||||:||.|           :|..:|:.|     ::|::..:|.:..:::.|...::..     .
Zfish   597 DHLTLLNVY-----------HAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDR-----F 645

  Fly  1084 DVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREP 1148
            ::|||.                         |.......|.||.:.:... .::|.|    ..|.
Zfish   646 NLPRRS-------------------------TEFTSRDYYINIRRALVTG-FFMQVA----HLER 680

  Fly  1149 SHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSD 1213
            :.|.|..|  .:..|::|||:|...    :..::::.|.|.|:..|||.|             :|
Zfish   681 TGHYLTVK--DNQVVQLHPSTVLDH----KPEWVLYNEFVLTTKNYIRTC-------------TD 726

  Fly  1214 FKVELHDGDFLFLLESGWII-LKAHDLETAEMVQCLRAEMIKLLEEKIR 1261
            .|.|             |:: :.....|.:...||.....::.:..|::
Zfish   727 IKPE-------------WLVKIAPQYYEMSNFPQCEAKRQLERIVAKLQ 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	238/800 (30%)
		DEXDc	471..619	CDD:238005	68/147 (46%)
		HELICc	781..871	CDD:197757	42/95 (44%)
		HA2	948..1029	CDD:214852	30/80 (38%)
		OB_NTP_bind	1070..1212	CDD:285018	26/141 (18%)
dhx15	NP_001108613.1	DEXDc	105..296	CDD:214692	89/199 (45%)
		DEXDc	128..269	CDD:238005	68/148 (46%)
		HELICc	356..449	CDD:197757	41/92 (45%)
		HA2	519..602	CDD:214852	30/82 (37%)
		OB_NTP_bind	636..739	CDD:285018	30/169 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810