DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx36

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001101148.1	Gene:	Dhx36 / 310461	RGDID:	1308767	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	1011	Identity:	376/1011 - (37%)
Similarity:	561/1011 - (55%)	Gaps:	136/1011 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELRLRYARHLYKEAKEICRDGIPCVY-------SICDLLQSNEQLAGRLDTSAFPSPKRSLFYDE 383
            |:.|.||:...::.||..|.....|:       .|..||.| .|.....|:.|    :.|.|..|
  Rat    53 EIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNS-VQAKNDKDSEA----QISWFAPE 112

  Fly   384 PAGGGVNPDAE---------HHQSPKPSHYARGQTSRNDGGH-QRNVEAQTREN-------RRLL 431
            ..|.|....:|         .:|..|..:..:......|..: .|:.|...::|       ::||
  Rat   113 DHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSEYLLQQNEPNLGLDQQLL 177

  Fly   432 QQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFF 496
            :...:::.:.||.::...||:||::...:.::.||.:..|.||||||||||:|||.||||||:..
  Rat   178 EDLQKKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIE 242

  Fly   497 RALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRI--GQLVGYQIRLENKVSQST-RLS 558
            |.:....:       |:||||||:|||.|||||||||.:..  |...||||||::::.:.. .:.
  Rat   243 RGIGSACR-------IVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSIL 300

  Fly   559 FCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAAL 623
            :|||||:|:.|.||..|.||:|:::||:|||:.:||.|:.::|:||..|.|||||||||||||..
  Rat   301 YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEK 365

  Fly   624 FSDYFGGAPVLDIPGRTFPVQQLFLEDILE-----------MSDFVMEYDTKYCRKLKKQEQEIL 677
            ||:|||..|::.|||.||||.:..||||:|           .|.|...:...:..:.:|:|:|.:
  Rat   366 FSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQGHVNRQEKEEKEAI 430

  Fly   678 ERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYI 742
            .:|...|.::                     :....||..|...:.:|:...::..||.::::||
  Rat   431 YKERWPAYIK---------------------ELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYI 474

  Fly   743 VEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAP 807
            |....|    |.||:||||:..|.::||.|:...:|  ::.:|:::||||.:...:|..||||.|
  Rat   475 VLEEED----GAILVFLPGWDNISTLHDLLMSQVMF--KSDRFLIIPLHSLMPTVNQTQVFKKTP 533

  Fly   808 PGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRV 872
            ||.||||::|||||||:||||.|:|:|.|.:||..||:..|:.::...|||:|||||||||||||
  Rat   534 PGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRV 598

  Fly   873 MPGVCIHLYTSYR------YQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEA 931
            .||.|.|||...|      ||       :|||.|.|||::.|:||.|:.......||.|   ::.
  Rat   599 QPGHCYHLYNGLRASLLDDYQ-------LPEILRTPLEELCLQIKILRLGGIAYFLSRL---MDP 653

  Fly   932 PTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLS 996
            |::::|:.::..|.::.|||.:::|||||.|||.|||:..|||::|:||:|.|||.||||||.||
  Rat   654 PSDEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLS 718

  Fly   997 NKSPFVSPLNKRTEAD-KCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNT 1060
            .|.|||.||.|...|| :.|.:.....||||||:||:..|.:..||| :...::|..|:|||.||
  Rat   719 FKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRG-FRYEKDYCWEYFLSSNT 782

  Fly  1061 LETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPN 1125
            |:.:.::|.|:.|.|:..|||....|:..|             .|.|.||.:::.:::||.|||.
  Rat   783 LQMLHNMKGQFAEHLLGAGFVSSRSPKDPK-------------ANINSDNEKIIKAVICAGLYPK 834

  Fly  1126 IVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRT 1190
            :.||    |:.:......|         :..|:.||.|.|||.|||.:.:.|...:|::..|:||
  Rat   835 VAKI----RLNLGKKRKMV---------KVHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRT 886

  Fly  1191 SAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKL 1255
            |:||:.||:.:....: ||.|.|..:: .|.|...:....||:.::.: ..|.:|:.||.|:..|
  Rat   887 SSIYLYDCTEVSPYCL-LFFGGDISIQ-KDKDQEIIAVDEWIVFQSPE-RIAHLVKGLRKELDIL 948

  Fly  1256 LEEKIRDPCLNLLH-------HKNGCRMIANIVHLI 1284
            |:|||..|     |       ....|.:::.|:.||
  Rat   949 LQEKIECP-----HPVDWNDTKSRDCAVLSAILDLI 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440	11/40 (28%)
		HrpA	419..1206	CDD:224557	327/814 (40%)
		DEXDc	471..619	CDD:238005	81/150 (54%)
		HELICc	781..871	CDD:197757	50/89 (56%)
		HA2	948..1029	CDD:214852	47/81 (58%)
		OB_NTP_bind	1070..1212	CDD:285018	43/141 (30%)
Dhx36	NP_001101148.1	HrpA	187..893	CDD:224557	321/776 (41%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	257..309		26/51 (51%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	326..329		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	379..620		102/274 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	490..549		27/60 (45%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	509..520		5/10 (50%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	621..690		29/71 (41%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	630..689		21/61 (34%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	833..897		25/76 (33%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	841..852		1/19 (5%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	862..892		13/29 (45%)
		Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..192		31/143 (22%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269\|PubMed:23651854	1..96		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		376/1011 (37%)
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..43
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	45..97		13/44 (30%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	45..67		4/13 (31%)
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	98..378		115/290 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4691
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720