Protein Alignment CG1582 and Ythdc2

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001414131.1
• Gene: Ythdc2 / 307446
• RGDID: 1563192
• Length: 1434
• Species: Rattus norvegicus
• Alignment Length: 1050
• Identity: 339/1050 - (32%)
• Similarity: 497/1050 - (47%)
• Gaps: 252/1050 - (24%)

  Fly   411 RNDGGHQRNVEAQTRE----NRRL---LQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            :.:.|:...|||:.||    :.||   :.|...:|.|..:...   |:.||.|.:.|.|:.:|:.
  Rat   151 KTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSF---RQSLPVFEKQEEIVKIIKE 212

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            :.||:|.||||.||:||:|||:||:.|        |..:| ..|.|||||||:||.|||||||||
  Rat   213 NKVVLIVGETGSGKTTQIPQFLLDDCF--------KNGIP-CRIFCTQPRRLAAIAVAERVAAER 268

  Fly   534 LDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRL-ASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .:||||.:|||||||::||..|.|:|||.|:|||.| |.|..|.:||||||||||||...|||||
  Rat   269 RERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLL 333

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            ..|::||::...||:||.||.|:..||..|||..||:.|.||.|.|:::||||||..:.:..:..
  Rat   334 TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEM 398

  Fly   663 TKYCRKLKKQEQEILEREL-EYADVQASGEAPGKKIKDEKLTLAETYQRY-----AEYSKPTCKS 721
            .||  |.:||.:|..:..| |:...|.:...|..:.:....:::|.|...     |.:|:.|.|.
  Rat   399 LKY--KKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKD 461

  Fly   722 IYLMEPMTINP------------------------------------------------------ 732
            :..:||..|..
  Rat   462 VNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQ 526

  Fly   733 ----------------------------------ELIESVLKYIVEGS----------------- 746
                                              :|:||....:..|:
  Rat   527 VEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAE 591

  Fly   747 ---------HDWPRE--------------------GTILIFLPGFGEIQSVHDSLL-DNALFSPR 781
                     |.:..|                    |.|||||||:.||..:.|.:| |:..|:..
  Rat   592 DRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADN 656

  Fly   782 AGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSN 846
            ..::.:..|||.:...||..|.|..|.|.|||:|||||||||:|::|.|||:|.|.:|||.||:.
  Rat   657 THRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDAL 721

  Fly   847 RNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIK 911
            ..:..|.:||:|:|:|.||||||||..||:|..|::..|:| ::|....||:.|:||:::.|..|
  Rat   722 NFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ-NMLEFQTPELLRMPLQELCLHTK 785

  Fly   912 TLQ----TFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRI 972
            .|.    |.|     ..|::..|.|....|..|:..|:.:.|:||.:.||.||:|||.|||:..:
  Rat   786 LLAPVNCTIA-----DFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHL 845

  Fly   973 GKLMLYGAIFQCLDSVLTIAACLSNKSPFVSP--LNKRTEADKCKRMFALGN-SDHLTVLNAYRK 1034
            ||::|...:.:|||.:||||..|:.:.|||.|  .:::..|..|::.|..|. |||:.:|.|::.
  Rat   846 GKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQA 910

  Fly  1035 WLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTL 1099
            | ..||...:  .|.:..::|||..|:|.|..::.|.|..|.:.|||      |.:...|    :
  Rat   911 W-QKARSDGW--ERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV------RARGGGD----I 962

  Fly  1100 TGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVK 1164
            ..|  |.|.:|..::.:.|.|.:|||:|.:   ||..:...|   |:|..             |:
  Rat   963 RDV--NTNSENWAVVKAALVAGMYPNLVHV---DRENVVLTG---PKEKK-------------VR 1006

  Fly  1165 IHPSSV------------NSQVSVFQA---PFLVFQEKVRTSAI-YIRDCSMLPLIAMVLFAG-- 1211
            .||:||            |.|.:..||   .:|::.|..|...| .||.||.:..:.:::|.|
  Rat  1007 FHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPA 1071

  Fly  1212 ----------SDFKV----------ELHD---GDFLFLLESGWIILKAHDLETAEMVQCLRAEMI 1253
                      |.|:.          |:.|   .:...|....|:..|. :.|.|.::..||.:..
  Rat  1072 RLTSNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKL-EPEAASLLLQLRQKWH 1135

  Fly  1254 KLLEEKIRDP 1263
            .|...::|.|
  Rat  1136 SLFLRRMRAP 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661
		zf-CCCH	245..272	CDD:459885
		HrpA	452..>1075	CDD:441249	273/771 (35%)
		OB_NTP_bind	1114..1212	CDD:400182	30/125 (24%)
Ythdc2	NP_001414131.1	None