DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx15

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001178526.1	Gene:	Dhx15 / 289693	RGDID:	1308072	Length:	795	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	242/823 - (29%)
Similarity:	378/823 - (45%)	Gaps:	160/823 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 PDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPA 455
            |..:...|...:|.|....|.:.........|......:.:..|.......||..|:..|.|||.
  Rat    75 PPLKASHSAHSTHSAHSTHSTHSAHSTHTGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPV 139

  Fly   456 FAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRL 520
            :...:|...::......|:.||||.||:||:||:.::  :.|:|..|.:      .:.||||||:
  Rat   140 WEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVE--YMRSLPGPKR------GVACTQPRRV 196

  Fly   521 SAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDE 585
            :|:.||:|||.|....:||.|||.||.|:..|..|.|.:.|.|:|||...:||||.....:|:||
  Rat   197 AAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDE 261

  Fly   586 VHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLED 650
            .|||:..:|.|:.:||.::|:|.|||||:|||||:|..|..||...|:|.|||||.|| ::|
  Rat   262 AHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPV-EIF--- 322

  Fly   651 ILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYS 715

  Rat   323 ----------------------------------------------------------------- 322

  Fly   716 KPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSL---LDNAL 777
                   |..||   ..:.:|:.::.:::.......||.:|:||.|..||......:   :|:
  Rat   323 -------YTPEP---ERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDD-- 375

  Fly   778 FSPRAGKFILVPLHSALSGEDQALVFKKAPPGK------RKIVLSTNIAETSVTIDDCVFVVDCG 836
            ..|..|...::||:|.|..:.|..:|:..||.|      ||:|:||||||||:|||..|||:|.|
  Rat   376 LGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPG 440

  Fly   837 LMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRV 901
            ..|:|.::....:|||.:..:|:|:|:||.|||||..||.|..|||...|:..:.....|||.|.
  Rat   441 FAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRS 505

  Fly   902 PLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAAL 966
            .|..:||::|.|    ..:.| |..:.::.|..::::.||..|..:.||:.:..||.||..:|..
  Rat   506 NLGSVVLQLKKL----GIDDL-VHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEF 565

  Fly   967 PVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNA 1031
            |:|.::.|:::....:.|.:.||:|.|.||....||.|...:..||:.|..||..:.||||:||.
  Rat   566 PLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNV 630

  Fly  1032 YRKWLDVARRGNYAASRNYAS-----EHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKN 1091
            |           :|..:|:.|     ::|::..:|.:..:::.|...::..     .::|||.
  Rat   631 Y-----------HAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDR-----FNLPRRS-- 677

  Fly  1092 ACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFK 1156
                                   |.......|.||.|.:... .::|.|    ..|.:.|.|..|
  Rat   678 -----------------------TDFTSRDYYINIRKALVTG-YFMQVA----HLERTGHYLTVK 714

  Fly  1157 TRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCS 1199
              .:..|::|||:|...    :..::::.|.|.|:..|||.|:
  Rat   715 --DNQVVQLHPSTVLDH----KPEWVLYNEFVLTTKNYIRTCT 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	237/795 (30%)
		DEXDc	471..619	CDD:238005	67/147 (46%)
		HELICc	781..871	CDD:197757	42/95 (44%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	27/130 (21%)
Dhx15	NP_001178526.1	HrpA	124..763	CDD:224557	235/774 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810