DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx8

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006247348.1	Gene:	Dhx8 / 287727	RGDID:	1310723	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	308/1212 - (25%)
Similarity:	480/1212 - (39%)	Gaps:	361/1212 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRGGHGVKHSYWQDRGTLVVQSVQGVSS 107
            :|:..|..|.|...:            .|.:||       |..||.......||....|::.|..
  Rat   317 VHISELRREGRVANV------------ADVVSK-------GQRVKVKVLSFTGTKTSLSMKDVDQ 362

  Fly   108 TRGNDSDGDRLRRYALAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPP 172
            ..|.|.:.:|.|...                      |:|..      ...||.||.       |
  Rat   363 ETGEDLNPNRRRNLV----------------------GETNE------ETSMRNPDR-------P 392

  Fly   173 SEQEILDMRADEKEALESIFDKAYEEREANRV-----WNLKFRIDHLLAHSPSEVRKAREAVLAA 232
            :...::.  |.|.|      |.:.|.:...|:     |.:|..|
  Rat   393 THLSLVS--APEVE------DDSLERKRLTRISDPEKWEIKQMI--------------------- 428

  Fly   233 AAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHV 297
                |...|.|::.|     :||.:          ...||         |.|  ||.|.:|...:
  Rat   429 ----AANVLSKEEFP-----DFDEE----------TGILP---------KVD--DEEDEDLEIEL 463

  Fly   298 EVRFPPGSRYPYE-----APFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLL 357
            ....||..|...:     :|...:|.....:.....::.|  |.||.:|:
  Rat   464 VEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSA--LAKERREL--------------- 511

  Fly   358 QSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEA 422
               :|.....:..:.|.             |:|   :|...|.|.  |.|          |.:.|
  Rat   512 ---KQAQREAEMDSIPM-------------GLN---KHWVDPLPD--AEG----------RQIAA 545

  Fly   423 QTRENRRLLQQFVERRK-----------EERYQKIIDGRKQLPAFAEIERILALIESSPVVVISG 476
            ..|....:.....|.:|           ::....|::.|:.||.:...|:::..:..:.::::.|
  Rat   546 NMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIG 610

  Fly   477 ETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLV 541
            |||.||:||:.|::.:..:           ....:|.||||||::|:.||:||:.|....:||.|
  Rat   611 ETGSGKTTQITQYLAEAGY-----------TSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEV 664

  Fly   542 GYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE 606
            ||.||.|:..|..|.:.:.|.|:|||....||.|.....:::||.|||:..:|.|..:||..:::
  Rat   665 GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQK 729

  Fly   607 RKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKK 671
            |:|:|:|:.||||:|..||.||..||:..|||||:||:.|:               ||
  Rat   730 RQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILY---------------TK------- 772

  Fly   672 QEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIE 736
                  |.|.:|.|.                            |..|...|:|.||
  Rat   773 ------EPETDYLDA----------------------------SLITVMQIHLTEP--------- 794

  Fly   737 SVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDN-ALFSPRAGKFILVPLHSALSGEDQA 800
                           .|.||:||.|..||.:..:.|.:. ....|...:.|::|::|||..|.|.
  Rat   795 ---------------PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQT 844

  Fly   801 LVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQR 865
            .:|..||||.||:|::|||||||:|||...:|||.|.:|:|.::|...::.|.:..:|:|.||||
  Rat   845 RIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQR 909

  Fly   866 KGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLE 930
            .|||||..||.|..|||...|:..:|...||||||..|...||.:|.:   ...:.||  .:.::
  Rat   910 AGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM---GINDLLS--FDFMD 969

  Fly   931 APTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACL 995
            ||..::::.|:.:|..:||||.|..||.||..:|..|::..:.|:::......|.:.:|||.:.|
  Rat   970 APPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSML 1034

  Fly   996 SNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNT 1060
            |.::.|..|.:|:..||:.|..|.....||||:|..|..|      .|...|..:..|:|:...:
  Rat  1035 SVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW------KNNKFSNPWCYENFIQARS 1093

  Fly  1061 LETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHN------GDNNRLLTSLLC 1119
            |....|::.|.|                            |:...|.      |.:...:...:|
  Rat  1094 LRRAQDIRKQML----------------------------GIMDRHKLDVVSCGKSTVRVQKAIC 1130

  Fly  1120 AALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY--------VKIHPSSVNSQVSV 1176
            :..:.|..|                 ::|.          :||        |.|||||     ::
  Rat  1131 SGFFRNAAK-----------------KDPQ----------EGYRTLIDQQVVYIHPSS-----AL 1163

  Fly  1177 F--QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKV 1216
            |  |..::|:.|.|.|:..|:|:.:.:....:|.||.:.|||
  Rat  1164 FNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKV 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	2/30 (7%)
		zf-CCCH	250..272	CDD:279036	2/21 (10%)
		RWD	<284..360	CDD:283440	15/80 (19%)
		HrpA	419..1206	CDD:224557	234/814 (29%)
		DEXDc	471..619	CDD:238005	55/147 (37%)
		HELICc	781..871	CDD:197757	42/89 (47%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	28/157 (18%)
Dhx8	XP_006247348.1	S1_DHX8_helicase	287..365	CDD:240189	14/66 (21%)
		DEXDc	583..768	CDD:214692	75/195 (38%)
		DEXDc	604..742	CDD:238005	55/148 (37%)
		HELICc	767..924	CDD:238034	70/236 (30%)
		HA2	986..1068	CDD:214852	29/81 (36%)
		OB_NTP_bind	1102..1201	CDD:285018	28/158 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810