DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and ucp12

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_588050.1	Gene:	ucp12 / 2539263	PomBaseID:	SPCC895.09c	Length:	1327	Species:	Schizosaccharomyces pombe

Alignment Length:	1231	Identity:	358/1231 - (29%)
Similarity:	569/1231 - (46%)	Gaps:	272/1231 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPPSE-------QEI----LD 179
            |.:.||:.:|..||.::|....:|...|:    :.:|:::..|...||:       |.:    |.
pombe   285 LISLGFRDIHAKEACQYCVSLEDALEWLI----IHVPEDDLPTRFLPSDYTTGISVQNLNSANLA 345

  Fly   180 MRADEKEALES--IFDKAY---EEREANRVWNLKFRIDHLLAHS--------PSEVRKAREAVLA 231
            :..:.|...|:  .||..:   :..|.|...:.::...||:..|        |:......:
pombe   346 IHYNAKRISETGYSFDLCFSTLQTFENNIQISSEYLQQHLIGESFDGNISLEPNSTEWDDD---- 406

  Fly   232 AAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFH 296
              .:|.|:.||.|              ..|....||             .:.|.......||:
pombe   407 --VSALQSILDNK--------------VSKIENGCR-------------VRIDYPTSEFGELF-- 440

  Fly   297 VEVRFPPGSRYPYEAPFIYLKTT------------------CHDIPHELRLRYARHLYKEAKEIC 343
            |:.|.|..| ||...|.:.|.:|                  ..|:..|..|.:   ||...:|
pombe   441 VDFRRPARS-YPAHIPLMSLSSTKRMASYIKLSILKKMVVYAMDLRGECMLSW---LYNHLQE-- 499

  Fly   344 RDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQ 408
                    :|.|.||:   :...|:.||             |..||:..:::..:|
pombe   500 --------NIEDFLQN---IGSLLNISA-------------ATIGVSLSSQNKSAP--------- 531

  Fly   409 TSRNDGGHQRNVEAQTRE-NRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVV 472
            |::.:...:..:..::|| :.:|...:.||.|...||..:..|::|||:....:|:..|:.|.||
pombe   532 TAKKNNSFKPKLFRRSRELSEKLCNNWSERVKSPSYQLKVREREKLPAWESRRKIMDAIQHSQVV 596

  Fly   473 VISGETGCGKSTQVPQFILDNWFF---RALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERL 534
            |||||||.||||||.|||||::..   :.||          .::||||||:|||.:|||||.||.
pombe   597 VISGETGSGKSTQVVQFILDHYLSSGEKDLQ----------TVVCTQPRRISAISLAERVAFERD 651

  Fly   535 DRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPL--LGSVTHVIVDEVHERSEESDFLL 597
            ..:|:.|||.:..|..:|:.|.|.|||||:||||:....|  |.:::.|:||||||||.|:|.||
pombe   652 TTVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLGFLSTLSCVVVDEVHERSIENDILL 716

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            .:||.::....:|||||||||:|:..|..|||.|..|.|.|||||::..::||
pombe   717 TLLKLVISRIPNLKVILMSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYIED------------ 769

  Fly   663 TKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEP 727
              :..||.:.:.|              .:.|.:|.|:.::          :|        :|:..
pombe   770 --FAPKLNEDDDE--------------EDVPRRKKKEYEI----------DY--------HLISR 800

  Fly   728 M--TINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEI-QSVHDSLLDNALFSPRAGKFILVP 789
            :  :|:.||..|              .|:||:||||...| :.:.:      :.|....||.::|
pombe   801 LVSSIDAELGSS--------------SGSILVFLPGVSNIARCIRE------IKSKDGSKFEVLP 845

  Fly   790 LHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDL 854
            ||::|:..:|...||...  ||||:.:|||||||:||||.|.|:|.|.:|:..:|..|::.:...
pombe   846 LHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVIDSGRVKQIDYDVERDLVTFKE 908

  Fly   855 VWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTL-QTFAS 918
            .|.|||..:||:||||||..|:|..|||....:..:|.|..||:.|..|.|:.|.:..| :.|:|
pombe   909 TWASRAACQQRRGRAGRVKKGICYKLYTRGFEEKGMLGQTPPEVLRTALSQVCLNVVPLVKRFSS 973

  Fly   919 ------RNTLSVLLETLEAPTEDSVLG-ALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLM 976
                  :.::...:.:|..|..|:.:. ||.:|..||||...:.||.||.:|.:||:|:::|||:
pombe   974 AGNSVNQGSIKKFMNSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLL 1038

  Fly   977 LYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARR 1041
            ::|:||..|:..|||.|.||.||||:..    .||.:.:...:.|..|.|.....|..||::...
pombe  1039 VFGSIFGYLEPALTITAILSTKSPFLGD----DEAREIRSKQSQGWGDVLADARVYHNWLEILET 1099

  Fly  1042 GNYAASRNYASEHFLSLNTLETIADLK------YQYLELLVSIGFVPIDVPRRRKNACDNILTLT 1100
            .....:..:..|..|...||:.|...:      .|.|||...                    .||
pombe  1100 RGVKKTVQWCEEMHLHYTTLQQIRQNRNELSEAAQLLELTTK--------------------KLT 1144

  Fly  1101 GVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKI 1165
            |....::.:|..:|::|:.|||.||:||.:.||:.::.:..|::..|......:|..:.:..:.|
pombe  1145 GNFDWYSTENLTVLSTLIAAALSPNVVKCVYPDKKFVASFSGSLEMEQEARLTKFYDQNNQRLFI 1209

  Fly  1166 HPSS---VNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVE-LHDG---DF 1223
            ||||   |||. :..:..|:.:::||.|:..::|:|:.:....|:|...:|..:: |..|   |.
pombe  1210 HPSSTMFVNSP-NASRCTFVAYEQKVETTKPFLRNCTPINTYGMILLGANDILIDPLGKGLILDQ 1273

  Fly  1224 LFLLESGW----IILKAHDLETAEMVQCLRAEMIKLLE-------EKIRDPCLNLLHHKNG 1273
            .:.::: |    |:||.       :.:||.|.:.:.||       |.....|:..|...||
pombe  1274 AYCIKA-WPKVVILLKM-------LKRCLDASLHERLESSSGLNYESEIHQCIRTLIAGNG 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	8/27 (30%)
		zf-CCCH	250..272	CDD:279036	3/21 (14%)
		RWD	<284..360	CDD:283440	22/93 (24%)
		HrpA	419..1206	CDD:224557	275/812 (34%)
		DEXDc	471..619	CDD:238005	80/152 (53%)
		HELICc	781..871	CDD:197757	40/89 (45%)
		HA2	948..1029	CDD:214852	33/80 (41%)
		OB_NTP_bind	1070..1212	CDD:285018	38/144 (26%)
ucp12	NP_588050.1	UBA	277..312	CDD:279021	8/26 (31%)
		RWD	406..504	CDD:214735	27/146 (18%)
		HrpA	545..1324	CDD:224557	293/889 (33%)
		DEXDc	594..737	CDD:238005	79/152 (52%)
		Helicase_C	811..927	CDD:278689	52/137 (38%)
		HA2	1008..1085	CDD:214852	33/80 (41%)
		OB_NTP_bind	1127..1256	CDD:285018	38/149 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	143	1.000	Domainoid score	I1164
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I399
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		otm47396
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1595
SonicParanoid	1	1.000	-	-		X384
TreeFam	1	0.960	-	-
	12	11.850