DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Ythdc2

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001156485.1	Gene:	Ythdc2 / 240255	MGIID:	2448561	Length:	1445	Species:	Mus musculus

Alignment Length:	1050	Identity:	339/1050 - (32%)
Similarity:	497/1050 - (47%)	Gaps:	252/1050 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 RNDGGHQRNVEAQTRE----NRRL---LQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            :.:.|:...|||:.||    :.||   :.|...:|.|..:...   |:.||.|.:.|.|:.:|:.
Mouse   162 KTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSF---RQSLPVFEKQEEIVKIIKE 223

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            :.||:|.||||.||:||:|||:||:.|        |..:| ..|.|||||||:||.|||||||||
Mouse   224 NKVVLIVGETGSGKTTQIPQFLLDDCF--------KNGIP-CRIFCTQPRRLAAIAVAERVAAER 279

  Fly   534 LDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRL-ASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .:||||.:|||||||::||..|.|:|||.|:|||.| |.|..|.:||||||||||||...|||||
Mouse   280 RERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLL 344

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            ..|::||::...||:||.||.|:..||..|||..||:.|.||.|.|:::||||||..:.:..:..
Mouse   345 TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEM 409

  Fly   663 TKYCRKLKKQEQEILEREL-EYADVQASGEAPGKKIKDEKLTLAETYQRY-----AEYSKPTCKS 721
            .||  |.:||.:|..:..| |:...|.:...|..:.:....:::|.|...     |.:|:.|.|.
Mouse   410 LKY--KKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKD 472

  Fly   722 IYLMEPMTINP------------------------------------------------------ 732
            :..:||..|..
Mouse   473 VNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQ 537

  Fly   733 ----------------------------------ELIESVLKYIVEGS----------------- 746
                                              :|:||....:..|:
Mouse   538 VEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAE 602

  Fly   747 ---------HDWPRE--------------------GTILIFLPGFGEIQSVHDSLL-DNALFSPR 781
                     |.:..|                    |.|||||||:.||..:.|.:| |:..|:..
Mouse   603 DRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADN 667

  Fly   782 AGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSN 846
            ..::.:..|||.:...||..|.|..|.|.|||:|||||||||:|::|.|||:|.|.:|||.||:.
Mouse   668 THRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDAL 732

  Fly   847 RNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIK 911
            ..:..|.:||:|:|:|.||||||||..||:|..|::..|:| ::|....||:.|:||:::.|..|
Mouse   733 NFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ-NMLEFQTPELLRMPLQELCLHTK 796

  Fly   912 TLQ----TFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRI 972
            .|.    |.|     ..|::..|.|....|..|:..|:.:.|:||.:.||.||:|||.|||:..:
Mouse   797 LLAPVNCTIA-----DFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHL 856

  Fly   973 GKLMLYGAIFQCLDSVLTIAACLSNKSPFVSP--LNKRTEADKCKRMFALGN-SDHLTVLNAYRK 1034
            ||::|...:.:|||.:||||..|:.:.|||.|  .:::..|..|::.|..|. |||:.:|.|::.
Mouse   857 GKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQA 921

  Fly  1035 WLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTL 1099
            | ..||...:  .|.:..::|||..|:|.|..::.|.|..|.:.|||      |.:...|    :
Mouse   922 W-QKARSDGW--ERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV------RARGGGD----I 973

  Fly  1100 TGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVK 1164
            ..|  |.|.:|..::.:.|.|.:|||:|.:   ||..:...|   |:|..             |:
Mouse   974 RDV--NTNSENWAVVKAALVAGMYPNLVHV---DRENVILTG---PKEKK-------------VR 1017

  Fly  1165 IHPSSV------------NSQVSVFQA---PFLVFQEKVRTSAI-YIRDCSMLPLIAMVLFAG-- 1211
            .||:||            |.|.:..||   .:|::.|..|...| .||.||.:..:.:::|.|
Mouse  1018 FHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPA 1082

  Fly  1212 ----------SDFKV----------ELHD---GDFLFLLESGWIILKAHDLETAEMVQCLRAEMI 1253
                      |.|:.          |:.|   .:...|....|:..|. :.|.|.::..||.:..
Mouse  1083 RLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKL-EPEAASLLLQLRQKWH 1146

  Fly  1254 KLLEEKIRDP 1263
            .|...::|.|
Mouse  1147 SLFLRRMRAP 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	322/958 (34%)
		DEXDc	471..619	CDD:238005	90/148 (61%)
		HELICc	781..871	CDD:197757	45/89 (51%)
		HA2	948..1029	CDD:214852	35/83 (42%)
		OB_NTP_bind	1070..1212	CDD:285018	42/169 (25%)
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		R3H_DEXH_helicase	61..119	CDD:100077
		DEXDc	225..364	CDD:238005	88/147 (60%)
		DEAH box	331..334		2/2 (100%)
		ANK	502..587	CDD:238125	4/84 (5%)
		ANK repeat	520..552	CDD:293786	0/31 (0%)
		ANK 1	521..553		0/31 (0%)
		Ank_4	524..574	CDD:290365	0/49 (0%)
		ANK 2	554..586		4/31 (13%)
		ANK repeat	554..582	CDD:293786	3/27 (11%)
		Helicase_C	625..757	CDD:278689	59/131 (45%)
		HA2	831..916	CDD:214852	35/84 (42%)
		OB_NTP_bind	954..1081	CDD:285018	41/157 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1303
		YTH	1304..1434	CDD:282058
		N6-methyladenosine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y5A9	1309..1311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820