Protein Alignment CG1582 and Dhx8

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_659080.2
• Gene: Dhx8 / 217207
• MGIID: 1306823
• Length: 1244
• Species: Mus musculus
• Alignment Length: 1212
• Identity: 308/1212 - (25%)
• Similarity: 480/1212 - (39%)
• Gaps: 361/1212 - (29%)

  Fly    43 LHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRGGHGVKHSYWQDRGTLVVQSVQGVSS 107
            :|:..|..|.|...:            .|.:||       |..||.......||....|::.|..
Mouse   319 VHISELRREGRVANV------------ADVVSK-------GQRVKVKVLSFTGTKTSLSMKDVDQ 364

  Fly   108 TRGNDSDGDRLRRYALAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPP 172
            ..|.|.:.:|.|...                      |:|..      ...||.||.       |
Mouse   365 ETGEDLNPNRRRNLV----------------------GETNE------ETSMRNPDR-------P 394

  Fly   173 SEQEILDMRADEKEALESIFDKAYEEREANRV-----WNLKFRIDHLLAHSPSEVRKAREAVLAA 232
            :...::.  |.|.|      |.:.|.:...|:     |.:|..|
Mouse   395 THLSLVS--APEVE------DDSLERKRLTRISDPEKWEIKQMI--------------------- 430

  Fly   233 AAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHV 297
                |...|.|::.|     :||.:          ...||         |.|  ||.|.:|...:
Mouse   431 ----AANVLSKEEFP-----DFDEE----------TGILP---------KVD--DEEDEDLEIEL 465

  Fly   298 EVRFPPGSRYPYE-----APFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLL 357
            ....||..|...:     :|...:|.....:.....::.|  |.||.:|:
Mouse   466 VEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSA--LAKERREL--------------- 513

  Fly   358 QSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEA 422
               :|.....:..:.|.             |:|   :|...|.|.  |.|          |.:.|
Mouse   514 ---KQAQREAEMDSIPM-------------GLN---KHWVDPLPD--AEG----------RQIAA 547

  Fly   423 QTRENRRLLQQFVERRK-----------EERYQKIIDGRKQLPAFAEIERILALIESSPVVVISG 476
            ..|....:.....|.:|           ::....|::.|:.||.:...|:::..:..:.::::.|
Mouse   548 NMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIG 612

  Fly   477 ETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLV 541
            |||.||:||:.|::.:..:           ....:|.||||||::|:.||:||:.|....:||.|
Mouse   613 ETGSGKTTQITQYLAEAGY-----------TSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEV 666

  Fly   542 GYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE 606
            ||.||.|:..|..|.:.:.|.|:|||....||.|.....:::||.|||:..:|.|..:||..:::
Mouse   667 GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQK 731

  Fly   607 RKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKK 671
            |:|:|:|:.||||:|..||.||..||:..|||||:||:.|:               ||
Mouse   732 RQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILY---------------TK------- 774

  Fly   672 QEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIE 736
                  |.|.:|.|.                            |..|...|:|.||
Mouse   775 ------EPETDYLDA----------------------------SLITVMQIHLTEP--------- 796

  Fly   737 SVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDN-ALFSPRAGKFILVPLHSALSGEDQA 800
                           .|.||:||.|..||.:..:.|.:. ....|...:.|::|::|||..|.|.
Mouse   797 ---------------PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQT 846

  Fly   801 LVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQR 865
            .:|..||||.||:|::|||||||:|||...:|||.|.:|:|.::|...::.|.:..:|:|.||||
Mouse   847 RIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQR 911

  Fly   866 KGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLE 930
            .|||||..||.|..|||...|:..:|...||||||..|...||.:|.:   ...:.||  .:.::
Mouse   912 AGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM---GINDLLS--FDFMD 971

  Fly   931 APTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACL 995
            ||..::::.|:.:|..:||||.|..||.||..:|..|::..:.|:::......|.:.:|||.:.|
Mouse   972 APPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSML 1036

  Fly   996 SNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNT 1060
            |.::.|..|.:|:..||:.|..|.....||||:|..|..|      .|...|..:..|:|:...:
Mouse  1037 SVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW------KNNKFSNPWCYENFIQARS 1095

  Fly  1061 LETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHN------GDNNRLLTSLLC 1119
            |....|::.|.|                            |:...|.      |.:...:...:|
Mouse  1096 LRRAQDIRKQML----------------------------GIMDRHKLDVVSCGKSTVRVQKAIC 1132

  Fly  1120 AALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY--------VKIHPSSVNSQVSV 1176
            :..:.|..|                 ::|.          :||        |.|||||     ::
Mouse  1133 SGFFRNAAK-----------------KDPQ----------EGYRTLIDQQVVYIHPSS-----AL 1165

  Fly  1177 F--QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKV 1216
            |  |..::|:.|.|.|:..|:|:.:.:....:|.||.:.|||
Mouse  1166 FNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKV 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871	2/30 (7%)
		RWD_DHX57	175..367	CDD:467661	34/201 (17%)
		zf-CCCH	245..272	CDD:459885	3/26 (12%)
		HrpA	452..>1075	CDD:441249	205/623 (33%)
		OB_NTP_bind	1114..1212	CDD:400182	23/107 (21%)
Dhx8	NP_659080.2	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189	14/66 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..396		12/69 (17%)
		HrpA	580..>1211	CDD:441249	236/790 (30%)
		DEAH box	709..712		2/2 (100%)