DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1582 and Dhx33

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_848144.3	Gene:	Dhx33 / 216877	MGIID:	2445102	Length:	698	Species:	Mus musculus

Alignment Length:	764	Identity:	230/764 - (30%)
Similarity:	360/764 - (47%)	Gaps:	162/764 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 RKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIIC 514
            |:.||.|....::||.:.:....|:.||||.||:||:||::.:...       :::.:    |..
Mouse    62 RRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGI-------SRQGI----IAV 115

  Fly   515 TQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVT 579
            |||||::||.:|.||:.|:...:|:||||.:|.|:..|:.||:.|.|.|:|||...||.||...:
Mouse   116 TQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYS 180

  Fly   580 HVIVDEVHERSEESDFLLLILKNLLRERKD-----LKVILMSATLNAALFSDYFGGAPVLDIPGR 639
            .||:||.|||:..:|.|..::|...:.||:     ||||:||||::..|||.||..||||.:.||
Mouse   181 CVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYLEGR 245

  Fly   640 TFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTL 704
            ..|:|..:                     .|:.:|:.|...| .:..|...|||
Mouse   246 QHPIQIFY---------------------TKQPQQDYLHAAL-VSVFQIHQEAP----------- 277

  Fly   705 AETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVH 769
                                                    .|.|      ||:||.|..||:::.
Mouse   278 ----------------------------------------ASQD------ILVFLTGQEEIEAMS 296

  Fly   770 DSLLDNALFSPRAGKFILV-PLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVV 833
            .:..|.|...|.....:|| ||:::|....|..||:.||.|.||:::||||||||:||....:||
Mouse   297 KTCRDIARHLPDGCPSMLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVV 361

  Fly   834 DCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEI 898
            |.|::|.|.::.:..:|.|.:..||:..|.||.|||||...|:|..|||...:: ......||||
Mouse   362 DTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFE-KFEKMTVPEI 425

  Fly   899 QRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQ---LTPLG 960
            ||..|..::|::..::.   .|.|:  .:.:..|:.|.:..|:.:|..:|||:.:|.   |||:|
Mouse   426 QRCNLASVILQLLAMKV---PNVLT--FDFMSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIG 485

  Fly   961 HHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDH 1025
            ..:||.|::.|..|.:|..:.|.|.:.:|||.:.||..|...:|..:|.|....::.|.....||
Mouse   486 RKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDH 550

  Fly  1026 LTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRK 1090
            :|:||.||.:.::.  ||    :::..|:|::...:..:|:::.|..|:.:.:. :||
Mouse   551 ITLLNIYRTFKNIG--GN----KDWCKENFVNSKNMLLVAEVRAQLREICLKMS-MPI------- 601

  Fly  1091 NACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRF 1155
                         .:..||... :...:..:|:.|..::.| |..|..|        .:|..
Mouse   602 -------------MSSRGDMES-VRRCMAHSLFMNTAELQT-DGTYATT--------DTHQP--- 640

  Fly  1156 KTRGDGYVKIHPSSVNSQVSVFQA-PFLVFQEKVRTSAIYIRDCSMLPL 1203
                   |.||||||     :|.. |..|    |.||.:|...|.|..|
Mouse   641 -------VAIHPSSV-----LFHCKPACV----VYTSLLYTNKCYMRDL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	230/764 (30%)
		DEXDc	471..619	CDD:238005	62/152 (41%)
		HELICc	781..871	CDD:197757	39/90 (43%)
		HA2	948..1029	CDD:214852	29/83 (35%)
		OB_NTP_bind	1070..1212	CDD:285018	30/135 (22%)
Dhx33	NP_848144.3	Required for nucleolar location. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	1..71		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50
		DEXDc	49..252	CDD:214692	82/200 (41%)
		DEXDc	83..225	CDD:238005	62/152 (41%)
		DEAH box	185..188		2/2 (100%)
		Helicase_C	282..399	CDD:278689	49/116 (42%)
		IBP39	409..>500	CDD:288304	28/96 (29%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	462..553		30/90 (33%)
		HA2	469..554	CDD:214852	29/84 (35%)
		Critical for rDNA-binding	536..550		1/13 (8%)
		OB_NTP_bind	588..688	CDD:285018	30/136 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810