Protein Alignment CG1582 and Dhx37

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_017176254.1
• Gene: Dhx37 / 208144
• MGIID: 3028576
• Length: 1161
• Species: Mus musculus
• Alignment Length: 1227
• Identity: 295/1227 - (24%)
• Similarity: 473/1227 - (38%)
• Gaps: 363/1227 - (29%)

  Fly   137 LEAYEHCSGDTEAALLLL---YRRYMRIPDEEQLTLEPPSEQEILDMRADEKEALESIFDKAYEE 198
            ||..:...|..|:.:|:|   .::..:.|        |||::|...:...|::.|:.:.::  :|
Mouse    33 LEGKDVLKGVDESNVLVLPGKRKKKTKAP--------PPSKKERKPLTKKERKVLQKVLEQ--KE 87

  Fly   199 REANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKYG 263
            :::.|.       :.|...|..:|.:|..::...                          |.|.|
Mouse    88 KKSQRA-------ELLQKLSEVQVSEAEMSLFYT--------------------------TAKLG 119

  Fly   264 PKCRFAHLPQ----QPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIP 324
            ...|..|:.:    ||......|..|:                               :..|
Mouse   120 TGDRMYHIKERKSGQPAARGQEKVSSL-------------------------------SGAH--- 150

  Fly   325 HELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGV 389
               |.|:.....:|..|...|..|           .|..|.:..||....|    .:..||..|:
Mouse   151 ---RKRHRSSSTEEDSESSEDSEP-----------EEATADQPRTSTGTEP----VHPPPAPSGI 197

  Fly   390 NPDAEHHQSP--------------------KPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQF 434
            |..|...|.|                    ||:.:..
Mouse   198 NSPAPTPQPPPSGISAPPKTPASAPPPPVAKPAVFIP---------------------------- 234

  Fly   435 VERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRAL 499
            |.|..|.:.:::     :||..||.:.|:..:...|:|::.||||.||:||||||:.:..:
Mouse   235 VNRTPEMQEERL-----KLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGY---- 290

  Fly   500 QLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGI 564
              .:::::    |..|:|||::|:.:::|||.| ::...::|.||||.|..|::.||:.|.|.|:
Mouse   291 --SSEDSI----IGVTEPRRVAAVAMSQRVAKE-MNLSHRVVSYQIRYEGNVTEETRIKFMTDGV 348

  Fly   565 LLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNL--LRERK--DLKVILMSATL------ 619
            ||:.:..|.||.....||:||.||||..:|.||.:|..:  ||.::  .||:::|||||
Mouse   349 LLKEIQKDFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFT 413

  Fly   620 -NAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEY 683
             |..||:.   ..||:.:..|.|||...| .....:.|:..|...|.|:         :.|.|..
Mouse   414 QNQRLFTT---PPPVIKVESRQFPVTVHF-NKRTPLDDYSGECFRKVCK---------IHRMLPA 465

  Fly   684 ADVQA--SGEA-------------------PGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEP 727
            ..:..  :|:|                   |.:|.:|.    ||..:|:.: |:...:....|..
Mouse   466 GGILVFLTGQAEVHALCRRLRKAFPFRCSQPQEKEEDS----AEGMRRFKK-SRTRARKAQAMAL 525

  Fly   728 MTINPELIESVLKYIV----EGSHDWPREGTILIFLPGFGEIQSVHDSL---LDNALFSPRAGK- 784
            ..||.:      .|.|    ||..|  ||          .|:....::|   ||..|....|.:
Mouse   526 PQINLD------NYSVLPAGEGDED--RE----------AEMDDEEEALGSDLDLDLGDSEANEG 572

  Fly   785 --------FILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEK 841
                    ..::||:|.|:.|.||.|||..|.|.|..|::||:||||:||....:|||||.:|::
Mouse   573 EQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 637

  Fly   842 CFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRY----QYHILAQPVPEIQRVP 902
            .:|....:.|..:.|||:|:|.||.|||||..||.|..||:|..:    |:     |.|||.|.|
Mouse   638 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQF-----PPPEITRRP 697

  Fly   903 LEQIVLRIKTL----------------QTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALD 951
            :|.::|::|.|                :...:...|.|.|..|:||.:..      |::.:....
Mouse   698 VEDLILQMKALSIEKVINFPFPTPPSVEALVAAEELLVALGALQAPPKQE------RMKKLQMSQ 756

  Fly   952 AEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPF------------VSP 1004
            ....:|.||..::..||..|..|::.......||...:.|.|.::.:..|            ::.
Mouse   757 LSCPITALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEKELAE 821

  Fly  1005 L-NKRTEADKCKRMFA-----LGNSDHLTVLNAYRKWLDVARRGNYAASRNYA--SEHFLSLNTL 1061
            | .:|....:.||.:|     |...|.:.:|.|             ..:..||  |..|...|.|
Mouse   822 LKGRRARVAQMKRTWAGQGPSLKLGDLMVLLGA-------------VGACEYAGCSPQFCQANGL 873

  Fly  1062 ETIADLKYQYL--ELLVSIGFVPIDVPRRRKNACDNI-LTLTGVEQNHNGDNNRLLTSLLCAALY 1123
            ...|.|:.:.|  :|..::..|           |... |.|....|.........|..::.|.|
Mouse   874 RYKAMLEIRRLRGQLTTAVNAV-----------CPEAGLFLDPKMQPPTESQVTYLRQIMAAGL- 926

  Fly  1124 PNIVKIMTPDRVYIQTAGGAVPREPSHHDL-------RFKT-RGDGYVKIHPSSVNSQVSVFQ-- 1178
                             |..:.|.....||       .:|| ..|..|.||||||     :|:
Mouse   927 -----------------GDHLARRVQSEDLLDPKWKNAYKTPLLDDPVFIHPSSV-----LFKEL 969

  Fly  1179 APFLVFQEKVRTSAIYIRDCSMLPL--IAMVLFAGSDFKVELHDGDFLFLLESGWII 1233
            ..|:|:||.|.|:.:|::..|.:.:  |..:|.:...|...|.:....:..|||.::
Mouse   970 PEFVVYQEIVETTKMYMKGVSTVEIQWIPSLLPSYCQFDAPLEEPAPSYCPESGQVL 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871	5/16 (31%)
		RWD_DHX57	175..367	CDD:467661	27/195 (14%)
		zf-CCCH	245..272	CDD:459885	5/26 (19%)
		HrpA	452..>1075	CDD:441249	204/712 (29%)
		OB_NTP_bind	1114..1212	CDD:400182	28/109 (26%)
Dhx37	XP_017176254.1	HrpA	248..>1036	CDD:441249	243/884 (27%)