DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and rha-1

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_495890.2	Gene:	rha-1 / 174417	WormBaseID:	WBGene00004355	Length:	1301	Species:	Caenorhabditis elegans

Alignment Length:	1163	Identity:	326/1163 - (28%)
Similarity:	512/1163 - (44%)	Gaps:	265/1163 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 ESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRN 253
            |....:..||..|:...:||..|     |....:..:::|:        ...|.|.:.|.:
Worm   141 EQYITQKAEEIAASETVDLKSEI-----HGGWTMENSKKAL--------NEFLQKMRLPQV---- 188

  Fly   254 FDRDGTCKYGPKCRFAHLPQQPTESDTTK------------------------KDSVDE-----N 289
                   .||.|.|         ||:|.|                        ...|.|     |
Worm   189 -------NYGTKIR---------ESNTVKTMETTAQIFVPQINKNLVGKGTGSNKKVSEAACAMN 237

  Fly   290 DNELWFHVEVRFPPGSRYPYEAPFIYLKTT-----CHDIPHELRLR---YARHLYKEAKEICRDG 346
            .....||:.:      ...|..|....|.:     ...||.:|..|   |.|....|..||
Worm   238 IVRQMFHLNI------MQSYSGPIKKSKVSTLPEIAISIPEDLSTRVTEYVRSCGLELPEI---- 292

  Fly   347 IPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSP-----KPSHYAR 406
                         ||       |||.|....||.          .|.:..|.|     ..|:.:.
Worm   293 -------------NE-------TSATPEAPTSLL----------TDVKLAQFPVSEICSASNISW 327

  Fly   407 GQTSRN-DGGHQRNVEAQT---RENRRLLQQFVER---RKEERYQKIIDGRKQLPAFAEIERILA 464
            ....:| :.....|::.:.   ....::.|:.:|:   ::.|...||...|.:||.....|.|:.
Worm   328 APPLQNWNPWRASNIDEEPLAFMSMEQISQRIMEKEDFKRGEALDKITAQRGELPVAQYRENIVQ 392

  Fly   465 LIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERV 529
            .:..:.|.:|.|||||||||||.||:|:::.       ...|......:.:||||:|||.:||||
Worm   393 TVAENRVTLIKGETGCGKSTQVAQFLLESFL-------ENSNGASFNAVVSQPRRISAISLAERV 450

  Fly   530 AAERLDRIGQLVGYQIRLENKVSQS-TRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEES 593
            |.||.:.:|:..||.:|.::...:. ..:.|||.|:|||.:.:.  |..::|||:||:|||..::
Worm   451 ANERGEEVGETCGYNVRFDSATPRPYGSIMFCTVGVLLRMMENG--LRGISHVIIDEIHERDVDT 513

  Fly   594 DFLLLILKNLLRERKDLKVILMSATLNAALFSDYF------GGAPVLDIPGRTFPVQQLFLEDIL 652
            ||:|::|:.::...:||:|:|||||::..||:::|      |..||:.:.|||||||..:|||||
Worm   514 DFVLIVLREMISTYRDLRVVLMSATIDTDLFTNFFSSIPDVGPTPVITMHGRTFPVQSFYLEDIL 578

  Fly   653 -EMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAP-----GKKIKDEKLTLAETYQRY 711
             .:.....|.|.|   |.||                 .|..|     |.:..|:|
Worm   579 HNLQHMPEEPDQK---KRKK-----------------GGPPPPDDDEGDEEVDDK---------- 613

  Fly   712 AEYSKPTCKSIYLMEPMTINPEL----------------IESVLKYIVEGSHDWPREGTILIFLP 760
                   .:::.::...:||..|                ||::|..|.....|    |.:|:|||
Worm   614 -------GRNMNILTDPSINESLKTAMSRISEKDIPFGVIEAILNDIASRGVD----GAVLVFLP 667

  Fly   761 GFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVT 825
            |:.||.::.:.||::..|. :|.|:.::||||.|:.::|..||... ||||||::||||||||:|
Worm   668 GWAEIMTLCNRLLEHQEFG-QANKYEILPLHSQLTSQEQRKVFNHY-PGKRKIIVSTNIAETSIT 730

  Fly   826 IDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQY-- 888
            |||.|:|:|....||:.:.||.||.....||.|:.|..||:||||||..|...||.:..|::.
Worm   731 IDDVVYVIDSCKAKERMYTSNNNMVHFATVWASKTNVIQRRGRAGRVRAGYAFHLCSKMRFEALD 795

  Fly   889 -HILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDA 952
             |..|    |:.|:||.||.|.||.|:..:....|.   :.|:.|..|.|:.:...|:.:||||.
Worm   796 DHGTA----EMLRIPLHQIALTIKLLRLGSVGEFLG---KALQPPPYDMVVESEAVLQAMGALDR 853

  Fly   953 EDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRM 1017
            ..:||.||..||.:|::..|.|:::.|........:..:|:.:|..:|||......:.....:|.
Worm   854 NLELTSLGKMLARMPIEPVIAKVLILGTALGAGSVMCDVASAMSFPTPFVPREKHHSRLSGTQRK 918

  Fly  1018 FALGN--SDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGF 1080
            || ||  |||:.:::..:.:.:..:.|..||.|.:...:.||...|:.....:.|.:::|.:...
Worm   919 FA-GNKFSDHVAIVSVIQGYREAVQMGASAAEREFCERYSLSNPVLKMTDGARRQLIDVLRNQCS 982

  Fly  1081 VPIDVPRRRKNACDNILTLTGVEQNHNGDNN--RLLTSLLCAALYPNIV------KIMTPDRVYI 1137
            .|.|:             |..:..|.||.:.  .|:.|||..|||||:.      |::|     |
Worm   983 FPEDI-------------LFDISVNVNGPDRELNLMRSLLVMALYPNVAYYVGKRKVLT-----I 1029

  Fly  1138 QTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLP 1202
            :.:...:.:               |..:.|.: |.|...|.:|.|||.|||||..|..:..|::.
Worm  1030 EQSSALINK---------------YSMLVPMN-NRQEMDFPSPLLVFTEKVRTRCISCKQMSVIS 1078

  Fly  1203 LIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMV---QCLRAEMIKLLE 1257
            .|.:::|...  |||. .|:.|..::. .|.::.:....|.::   .|:.|.::|..|
Worm  1079 AIQLLVFGSR--KVEC-VGEGLVRIDE-TITIRMNVSTAAALIGLRPCIEALLVKSCE 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036	4/21 (19%)
		RWD	<284..360	CDD:283440	17/88 (19%)
		HrpA	419..1206	CDD:224557	264/834 (32%)
		DEXDc	471..619	CDD:238005	62/148 (42%)
		HELICc	781..871	CDD:197757	46/89 (52%)
		HA2	948..1029	CDD:214852	27/82 (33%)
		OB_NTP_bind	1070..1212	CDD:285018	38/149 (26%)
rha-1	NP_495890.2	DSRM	6..71	CDD:214634
		DSRM	173..243	CDD:214634	15/97 (15%)
		HrpA	337..>974	CDD:224557	228/696 (33%)
		DEXDc	398..539	CDD:238005	62/149 (42%)
		Helicase_C	649..739	CDD:278689	44/95 (46%)
		HA2	847..931	CDD:214852	27/84 (32%)
		OB_NTP_bind	971..1086	CDD:285018	37/148 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820