Protein Alignment CG1582 and DHX36

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_065916.2
• Gene: DHX36 / 170506
• HGNCID: 14410
• Length: 1008
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 359/904 - (39%)
• Similarity: 528/904 - (58%)
• Gaps: 104/904 - (11%)

  Fly   411 RNDGGHQRNVEAQTREN-------RRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            ||.....|:.|...:||       ::||:...:::.:.||.::...|::||::...:.::.||::
Human   158 RNRSYIDRDSEYLLQENEPDGTLDQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDN 222

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            ..|.||||||||||:|||.||||||:..|......:       |:||||||:|||.|||||||||
Human   223 HQVTVISGETGCGKTTQVTQFILDNYIERGKGSACR-------IVCTQPRRISAISVAERVAAER 280

  Fly   534 LDRI--GQLVGYQIRLENKVSQST-RLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDF 595
            .:..  |...||||||::::.:.. .:.:|||||:|:.|.|||.|.||:|:::||:|||:.:||.
Human   281 AESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDV 345

  Fly   596 LLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVME 660
            |:.::|:||..|.|||||||||||||..||:|||..|::.|||.||||.:..|||::|...:|.|
Human   346 LMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPE 410

  Fly   661 YDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTL-AETYQRYA-----EYSKPTC 719
                     :|:.:...:|......|       .::.|:||..: .|.:..|.     .||..|.
Human   411 ---------QKEHRSQFKRGFMQGHV-------NRQEKEEKEAIYKERWPDYVRELRRRYSASTV 459

  Fly   720 KSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGK 784
            ..|.:||...::..||.::::|||....|    |.||:||||:..|.::||.|:...:|  ::.|
Human   460 DVIEMMEDDKVDLNLIVALIRYIVLEEED----GAILVFLPGWDNISTLHDLLMSQVMF--KSDK 518

  Fly   785 FILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNM 849
            |:::||||.:...:|..|||:.|||.||||::|||||||:||||.|:|:|.|.:||..||:..|:
Human   519 FLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNI 583

  Fly   850 ESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYR------YQYHILAQPVPEIQRVPLEQIVL 908
            .::...|||:|||||||||||||.||.|.|||...|      ||       :|||.|.|||::.|
Human   584 STMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQ-------LPEILRTPLEELCL 641

  Fly   909 RIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIG 973
            :||.|:.......||.|   ::.|:.::||.::..|.::.|||.:::|||||.|||.|||:..||
Human   642 QIKILRLGGIAYFLSRL---MDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIG 703

  Fly   974 KLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALG-NSDHLTVLNAYRKWLD 1037
            |::|:||:|.|||.||||||.||.|.|||.||.|...||..::..|.. .||||||:||:..|.:
Human   704 KMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVVNAFEGWEE 768

  Fly  1038 VARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGV 1102
            ..||| :...::|..|:|||.|||:.:.::|.|:.|.|:..|||....|:             ..
Human   769 ARRRG-FRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPK-------------DP 819

  Fly  1103 EQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHP 1167
            |.|.|.||.:::.:::||.|||.:.||    |:.:......|         :..|:.||.|.:||
Human   820 ESNINSDNEKIIKAVICAGLYPKVAKI----RLNLGKKRKMV---------KVYTKTDGLVAVHP 871

  Fly  1168 SSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWI 1232
            .|||.:.:.|...:|::..|:|||:||:.||:.:....: ||.|.|..:: .|.|...:....||
Human   872 KSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL-LFFGGDISIQ-KDNDQETIAVDEWI 934

  Fly  1233 ILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLLH-------HKNGCRMIANIVHLI 1284
            :.:: ....|.:|:.||.|:..||:|||..|     |       ....|.:::.|:.||
Human   935 VFQS-PARIAHLVKELRKELDILLQEKIESP-----HPVDWNDTKSRDCAVLSAIIDLI 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661
		zf-CCCH	245..272	CDD:459885
		HrpA	452..>1075	CDD:441249	286/638 (45%)
		OB_NTP_bind	1114..1212	CDD:400182	30/97 (31%)
DHX36	NP_065916.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852	1..200		10/41 (24%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8	1..104
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321	1..51
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078	53..105
		DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896	53..75
		RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79	106..386		107/234 (46%)
		DEXHc_DHX36	207..386	CDD:350739	96/185 (52%)
		HrpA	215..>776	CDD:441249	273/600 (46%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	265..317		26/51 (51%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	334..337		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79	387..628		106/269 (39%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	498..557		27/60 (45%)
		Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398	517..528		6/10 (60%)
		WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79	629..698		30/71 (42%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	638..697		22/61 (36%)
		OB_NTP_bind	831..917	CDD:400182	31/99 (31%)
		OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79	841..905		24/76 (32%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	849..860		1/19 (5%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	870..900		13/29 (45%)