DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1582 and DHX9

DIOPT Version :9

Sequence 1:NP_001285098.1 Gene:CG1582 / 32021 FlyBaseID:FBgn0030246 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:1326 Identity:391/1326 - (29%)
Similarity:596/1326 - (44%) Gaps:304/1326 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 KSQAADNKSRKTELHVLRLND-ESRQM-------------TMDTLRQIHG-----------PEFQ 69
            |..|..|.:|....:::|:|: :|.::             |.||.....|           |...
Human    54 KKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLA 118

  Fly    70 LDDISKYKDRGRGGHGVKHSYWQDRGTLVVQSVQGVSSTRGNDSDGDRLRRYALAKLENYGFQAV 134
            | ......:.|..|:||....| |||                            |.|::|     
Human   119 L-KAENNSEVGASGYGVPGPTW-DRG----------------------------ANLKDY----- 148

  Fly   135 HCLEAYEHCSGDTEAALLLLYRRYMRIPDEE-QLTLEPPSEQEILDMRA---------DEKEALE 189
                                   |.|..::| |.||    |.|.:|:.|         :.|..|.
Human   149 -----------------------YSRKEEQEVQATL----ESEEVDLNAGLHGNWTLENAKARLN 186

  Fly   190 SIFDK-----AYEEREANRVWNLKFRIDHLLAHSPSEVRK--AREAVLAAAAAAAQAALDKKKKP 247
            ..|.|     .|:..:.....|..| |..:..:.....|:  |||.......||...||...:  
Human   187 QYFQKEKIQGEYKYTQVGPDHNRSF-IAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVR-- 248

  Fly   248 PLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAP 312
                               :..||......|..|||...:.        ||         ||:. 
Human   249 -------------------QLYHLGVVEAYSGLTKKKEGET--------VE---------PYKV- 276

  Fly   313 FIYLKTTCHDIPHELRLRYARHLYKEAKEICRD-GIPCVYSICDLLQSNEQLAGRLDTSAFPSPK 376
                 ....|:.|:|: ...:.|..|......| .:|...:|..|.|..            ||.:
Human   277 -----NLSQDLEHQLQ-NIIQELNLEILPPPEDPSVPVALNIGKLAQFE------------PSQR 323

  Fly   377 RSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGG-------HQRNVEAQTRENRRLLQQF 434
            ::..       ||.|     .||..|::....:|..|.|       .|.:::.:    ..|:.|.
Human   324 QNQV-------GVVP-----WSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLK----NELMYQL 372

  Fly   435 VERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRAL 499
               .::...|.|:..|:.||.......||..|..:.||:|.|.|||||:|||||||||::.    
Human   373 ---EQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFI---- 430

  Fly   500 QLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQ-STRLSFCTTG 563
               ..:......|:.|||||:||:.||||||.||.:..|:..||.:|.|:.:.: ...:.|||.|
Human   431 ---QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVG 492

  Fly   564 ILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYF 628
            :|||:|.:.  :..::||||||:|||...:||||::|:::::...:::::|||||::.::|.:||
Human   493 VLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYF 555

  Fly   629 GGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQ-ASGEA 692
            ...|::::.|||:|||:.||||.::|:.||.....|     ||::::....|.:.|:.. ..|:.
Human   556 FNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDK-----KKKDKDDDGGEDDDANCNLICGDE 615

  Fly   693 PGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILI 757
            .|   .:.:|::::..::...:                  ||||::||||  .:.:.|  |.:|:
Human   616 YG---PETRLSMSQLNEKETPF------------------ELIEALLKYI--ETLNVP--GAVLV 655

  Fly   758 FLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAET 822
            ||||:..|.::...|..|..|.  :.::.::||||.:..|:|..||...|.|..|::||||||||
Human   656 FLPGWNLIYTMQKHLEMNPHFG--SHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAET 718

  Fly   823 SVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQ 887
            |:||:|.|:|:|....|.|.|.::.||.:...||.|:.|.:|||||||||.||.|.||.:..|::
Human   719 SITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFE 783

  Fly   888 YHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDA 952
             .:.....||:.|.||.:|.|.||.|:.......|:   :.:|.|..|:|:.|...||::.||||
Human   784 -RLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLA---KAIEPPPLDAVIEAEHTLRELDALDA 844

  Fly   953 EDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRM 1017
            .|:|||||..||.||::.|.||:|:.|.||...|::.||||......||:   |:........|.
Human   845 NDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFI---NEGKRLGYIHRN 906

  Fly  1018 FALGN--SDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGF 1080
            || ||  |||:.:|:.::.| |.||.|...|...:.....|::.||....:.|.|..|:|::.||
Human   907 FA-GNRFSDHVALLSVFQAW-DDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGF 969

  Fly  1081 VPIDVPRRRKNACDNILTLTGVEQNHNGDNN-RLLTSLLCAALYPNIV------KIMTPDRVYIQ 1138
             |.|        |    .||.|..|...||| .::.|||...:|||:.      ||:|       
Human   970 -PED--------C----LLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILT------- 1014

  Fly  1139 TAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVN----SQVSVFQAPFLVFQEKVRTSAIYIRDCS 1199
                              |.|...: ||.||||    ||...:.:||.||.||:||.||..:..:
Human  1015 ------------------TEGRNAL-IHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMT 1060

  Fly  1200 MLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILK-AHDLETAEMVQCLRAEMIKLLEEKIRDP 1263
            ::..:.::|||..  ||: .||.  .:|...||.|: :|  |.|..:..|||.|..|:.|..:.|
Human  1061 LVTPLQLLLFASK--KVQ-SDGQ--IVLVDDWIKLQISH--EAAACITGLRAAMEALVVEVTKQP 1118

  Fly  1264 C-LNLLHHKNGCRMIANIVHLISKNS 1288
            . ::.|...|. ||: |::..||:.|
Human  1119 AIISQLDPVNE-RML-NMIRQISRPS 1142

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG1582NP_001285098.1 UBA_like_SF 123..154 CDD:304366 3/30 (10%)
zf-CCCH 250..272 CDD:279036 1/21 (5%)
RWD <284..360 CDD:283440 14/76 (18%)
HrpA 419..1206 CDD:224557 280/801 (35%)
DEXDc 471..619 CDD:238005 65/148 (44%)
HELICc 781..871 CDD:197757 41/89 (46%)
HA2 948..1029 CDD:214852 37/82 (45%)
OB_NTP_bind 1070..1212 CDD:285018 47/152 (31%)
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250 50/279 (18%)
DSRM 5..69 CDD:214634 4/14 (29%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9