DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHX8

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	1347	Identity:	321/1347 - (23%)
Similarity:	517/1347 - (38%)	Gaps:	438/1347 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LAKLENYGFQAVHCLE-------------------AYEHCSGDTEAALLL---------LYRRYM 159
            |||||.....:..|.|                   |.::.:.||..|.|:         |....:
Human    22 LAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLL 86

  Fly   160 RIPDEEQLTLEPP-----SEQEILDMRADEKEALESIFDKAYEEREANRVWNLKFRIDHLLAHSP 219
            |:..    |:.||     |:..::..:. |||.|:.:|....:....    :::..:|.......
Human    87 RLIQ----TMRPPAKPSTSKDPVVKPKT-EKEKLKELFPVLCQPDNP----SVRTMLDEDDVKVA 142

  Fly   220 SEVRKAREAVLAAAA-------AAAQAALDKKKKPPLRCRNFDRDG------------------- 258
            .:|.|..||::.:||       |..:....|||:...|.||.|||.
Human   143 VDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSR 207

  Fly   259 -----------TCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPP------GSR 306
                       ..:|..:.|     .|....|...:|...|.:.:.|....|..||      |..
Human   208 SRSRTRERNKVKSRYRSRSR-----SQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDI 267

  Fly   307 YPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSA 371
            |..:...| ::..|......||.|:...::  ..|:.|:|  .|.::.|::...:::  ::...:
Human   268 YNGKVTSI-MQFGCFVQLEGLRKRWEGLVH--ISELRREG--RVANVADVVSKGQRV--KVKVLS 325

  Fly   372 FPSPKRSLF---YDEPAGGGVNPDAEHH-----------QSP-KPSH------------------ 403
            |...|.||.   .|:..|..:||:...:           ::| :|:|
Human   326 FTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKR 390

  Fly   404 ---------------------------------------------------------YARGQTSR 411
                                                                     :.||.|.:
Human   391 LTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQ 455

  Fly   412 N------------DGGHQRNVEAQT---RENRRLLQQFVERRKE--------------------- 440
            :            ||...:....|:   :|.|.|.|  .:|..|
Human   456 SMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQ--AQREAEMDSIPMGLNKHWVDPLPDAEG 518

  Fly   441 ----------------------------------ERYQKIIDGRKQLPAFAEIERILALIESSPV 471
                                              :....|::.|:.||.:...|:::..:..:.:
Human   519 RQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQI 583

  Fly   472 VVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDR 536
            :::.||||.||:||:.|::.:..:           ....:|.||||||::|:.||:||:.|....
Human   584 LIVIGETGSGKTTQITQYLAEAGY-----------TSRGKIGCTQPRRVAAMSVAKRVSEEFGCC 637

  Fly   537 IGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILK 601
            :||.|||.||.|:..|..|.:.:.|.|:|||....||.|.....:::||.|||:..:|.|..:||
Human   638 LGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLK 702

  Fly   602 NLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYC 666
            ..:::|:|:|:|:.||||:|..||.||..||:..|||||:||:.|:               ||
Human   703 KTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILY---------------TK-- 750

  Fly   667 RKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTIN 731
                       |.|.:|.|.                            |..|...|:|.||
Human   751 -----------EPETDYLDA----------------------------SLITVMQIHLTEP---- 772

  Fly   732 PELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDN-ALFSPRAGKFILVPLHSALS 795
                                .|.||:||.|..||.:..:.|.:. ....|...:.|::|::|||.
Human   773 --------------------PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALP 817

  Fly   796 GEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRA 860
            .|.|..:|..||||.||:|::|||||||:|||...:|||.|.:|:|.::|...::.|.:..:|:|
Human   818 SEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQA 882

  Fly   861 NAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVL 925
            .||||.|||||..||.|..|||...|:..:|...||||||..|...||.:|.:   ...:.||
Human   883 QAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM---GINDLLS-- 942

  Fly   926 LETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLT 990
            .:.::||..::::.|:.:|..:||||.|..||.||..:|..|::..:.|:::......|.:.:||
Human   943 FDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLT 1007

  Fly   991 IAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHF 1055
            |.:.||.::.|..|.:|:..||:.|..|.....||||:|..|..|      .|...|..:..|:|
Human  1008 IVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW------KNNKFSNPWCYENF 1066

  Fly  1056 LSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHN------GDNNRLL 1114
            :...:|....|::.|.|                            |:...|.      |.:...:
Human  1067 IQARSLRRAQDIRKQML----------------------------GIMDRHKLDVVSCGKSTVRV 1103

  Fly  1115 TSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY--------VKIHPSSVN 1171
            ...:|:..:.|..|                 ::|.          :||        |.|||||
Human  1104 QKAICSGFFRNAAK-----------------KDPQ----------EGYRTLIDQQVVYIHPSS-- 1139

  Fly  1172 SQVSVF--QAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKV 1216
               ::|  |..::|:.|.|.|:..|:|:.:.:....:|.||.:.|||
Human  1140 ---ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKV 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	12/58 (21%)
		zf-CCCH	250..272	CDD:279036	8/51 (16%)
		RWD	<284..360	CDD:283440	18/81 (22%)
		HrpA	419..1206	CDD:224557	237/861 (28%)
		DEXDc	471..619	CDD:238005	55/147 (37%)
		HELICc	781..871	CDD:197757	42/89 (47%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	28/157 (18%)
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668	11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266		22/117 (19%)
		RpsA	<263..422	CDD:223613	23/165 (14%)
		S1_DHX8_helicase	265..343	CDD:240189	17/84 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372		6/34 (18%)
		HrpA	557..1219	CDD:224557	236/789 (30%)
		DEAH box	685..688		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810