DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1582 and Dhx9

DIOPT Version :10

Sequence 1:NP_572663.1 Gene:CG1582 / 32021 FlyBaseID:FBgn0030246 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001392438.1 Gene:Dhx9 / 13211 MGIID:108177 Length:1384 Species:Mus musculus


Alignment Length:964 Identity:327/964 - (33%)
Similarity:497/964 - (51%) Gaps:145/964 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 DLLQSNEQLAGRLDTSAFPSPK----------RSLFYDEPA----GGGVNPDAEHHQSPKPSHYA 405
            ||....:.:...||....|.|.          ..|.:.||:    ..||.|     .||..|::.
Mouse   284 DLELQLQNVVQELDLEIVPPPVDPSMPVILNIGKLAHFEPSQRQNAVGVVP-----WSPPQSNWN 343

  Fly   406 RGQTSRNDGG--HQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            ...:|..|.|  ...:.|..:.:.:..|...:|  ::...|.::..|:.||.......||..|.|
Mouse   344 PWTSSNIDEGPLAYASTEQISMDLKNELTYQME--QDHNLQSVLQERELLPVKKFEAEILEAISS 406

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            :.||:|.|.|||||:|||||:|||::.       ..:......|:.|||||:||:.||||||.||
Mouse   407 NSVVIIRGATGCGKTTQVPQYILDDFI-------QNDRAAECNIVVTQPRRISAVAVAERVAYER 464

  Fly   534 LDRIGQLVGYQIRLENKVSQ-STRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .:..|:..||.:|.|:.:.: ...:.|||.|:|||:|.:.  :..::||||||:|||...:||||
Mouse   465 GEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLL 527

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            ::|::::....:::::|||||::..:|.:||...|::::.|||||||:.||||.::|:.|:....
Mouse   528 VVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQEYFLEDCIQMTQFIPPPK 592

  Fly   663 TKYCRKLKKQEQEILERELEYADVQ-ASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLME 726
            .|     ||:::|....|.:.|:.. ..|:..|   .:.||::::..::...:            
Mouse   593 DK-----KKKDKEDDGGEDDDANCNLICGDEYG---PETKLSMSQLNEKETPF------------ 637

  Fly   727 PMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLH 791
                  ||||::||||  .:.:.|  |.:|:||||:..|.::...|.:|:.|.  :.::.::|||
Mouse   638 ------ELIEALLKYI--ETLNVP--GAVLVFLPGWNLIYTMQKHLENNSHFG--SHRYQILPLH 690

  Fly   792 SALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVW 856
            |.:..|:|..||...|.|..|::|||||||||:||:|.|:|:|....|.|.|.::.||.:...||
Mouse   691 SQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVW 755

  Fly   857 VSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNT 921
            .|:.|.:|||||||||.||.|.||.:..|:. .:.....||:.|.||.:|.|.||.|:.......
Mouse   756 ASKTNLEQRKGRAGRVRPGFCFHLCSRARFD-RLETHMTPEMFRTPLHEIALSIKLLRLGGIGQF 819

  Fly   922 LSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLD 986
            |:   :.:|.|..|:|:.|...||::.||||.|:|||||..||.||::.|.||:|:.|.||...|
Mouse   820 LA---KAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGD 881

  Fly   987 SVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGN--SDHLTVLNAYRKWLDVARRGNYAASRN 1049
            :|.||:|......||:|. .||  .....|.|| ||  |||:.:|:.::.| |.||.....|...
Mouse   882 AVCTISAATCFPEPFISE-GKR--LGYIHRNFA-GNRFSDHVALLSVFQAW-DDARMSGEEAEIR 941

  Fly  1050 YASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNN-RL 1113
            :..:..|::.||....:.|.|..|:|::.|| |.|        |    .||.|..|...||| .:
Mouse   942 FCEQKRLNMATLRMTWEAKVQLKEILINSGF-PED--------C----LLTQVFTNTGPDNNLDV 993

  Fly  1114 LTSLLCAALYPNIV------KIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVN- 1171
            :.|||...:|||:.      ||:|                         |.|...: ||.|||| 
Mouse   994 VISLLAFGVYPNVCYHKEKRKILT-------------------------TEGRNAL-IHKSSVNC 1032

  Fly  1172 ---SQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWII 1233
               ||...:.:||.||.||:||.||..:..:::..:.::|||..  ||: .||..:|:  ..||.
Mouse  1033 PFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASK--KVQ-SDGQIVFI--DDWIR 1092

  Fly  1234 LK-AHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLL--------HHKNGCRMIA 1278
            |: :|  |.|..:..|||.|..|:.|..:.|  |::        |..|..|.|:
Mouse  1093 LQISH--EAAACITALRAAMEALVVEVSKQP--NIISQLDPVNEHMLNTIRQIS 1142

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1582NP_572663.1 UBA_like_SF 123..154 CDD:473871
RWD_DHX57 175..367 CDD:467661 2/11 (18%)
zf-CCCH 245..272 CDD:459885
HrpA 452..>1075 CDD:441249 236/626 (38%)
OB_NTP_bind 1114..1212 CDD:400182 32/107 (30%)
Dhx9NP_001392438.1 DSRM_DHX9_rpt1 3..71 CDD:380683
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 5..9
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 53..55
DSRM_DHX9_rpt2 181..255 CDD:380684
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 185..189
Interaction with BRCA1. /evidence=ECO:0000250|UniProtKB:Q08211 233..328 9/43 (21%)
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 237..239
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000250|UniProtKB:Q08211 258..667 136/428 (32%)
Necessary for interaction with H2AX. /evidence=ECO:0000250|UniProtKB:Q08211 316..955 250/695 (36%)
DEXHc_DHX9 333..566 CDD:350730 87/248 (35%)
MTAD. /evidence=ECO:0000250|UniProtKB:Q08211 334..383 10/55 (18%)
HrpA 391..>889 CDD:441249 210/542 (39%)
Core helicase. /evidence=ECO:0000250|UniProtKB:Q08211 401..812 173/452 (38%)
DEAH box 514..517 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 589..611 6/26 (23%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 589..598 3/13 (23%)
HA2. /evidence=ECO:0000250|UniProtKB:Q08211 834..922 42/91 (46%)
OB-fold. /evidence=ECO:0000250|UniProtKB:Q08211 961..1077 47/156 (30%)
OB_NTP_bind 997..1076 CDD:400182 31/104 (30%)
Nuclear localization signal (NLS2). /evidence=ECO:0000250|UniProtKB:Q08211 1158..1176
Blue background indicates that the domain is not in the aligned region.

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