DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx9

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_011246220.1	Gene:	Dhx9 / 13211	MGIID:	108177	Length:	1384	Species:	Mus musculus

Alignment Length:	964	Identity:	327/964 - (33%)
Similarity:	497/964 - (51%)	Gaps:	145/964 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 DLLQSNEQLAGRLDTSAFPSPK----------RSLFYDEPA----GGGVNPDAEHHQSPKPSHYA 405
            ||....:.:...||....|.|.          ..|.:.||:    ..||.|     .||..|::.
Mouse   284 DLELQLQNVVQELDLEIVPPPVDPSMPVILNIGKLAHFEPSQRQNAVGVVP-----WSPPQSNWN 343

  Fly   406 RGQTSRNDGG--HQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIES 468
            ...:|..|.|  ...:.|..:.:.:..|...:|  ::...|.::..|:.||.......||..|.|
Mouse   344 PWTSSNIDEGPLAYASTEQISMDLKNELTYQME--QDHNLQSVLQERELLPVKKFEAEILEAISS 406

  Fly   469 SPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAER 533
            :.||:|.|.|||||:|||||:|||::.       ..:......|:.|||||:||:.||||||.||
Mouse   407 NSVVIIRGATGCGKTTQVPQYILDDFI-------QNDRAAECNIVVTQPRRISAVAVAERVAYER 464

  Fly   534 LDRIGQLVGYQIRLENKVSQ-STRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .:..|:..||.:|.|:.:.: ...:.|||.|:|||:|.:.  :..::||||||:|||...:||||
Mouse   465 GEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLL 527

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            ::|::::....:::::|||||::..:|.:||...|::::.|||||||:.||||.::|:.|:....
Mouse   528 VVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQEYFLEDCIQMTQFIPPPK 592

  Fly   663 TKYCRKLKKQEQEILERELEYADVQ-ASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLME 726
            .|     ||:::|....|.:.|:.. ..|:..|   .:.||::::..::...:
Mouse   593 DK-----KKKDKEDDGGEDDDANCNLICGDEYG---PETKLSMSQLNEKETPF------------ 637

  Fly   727 PMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLH 791
                  ||||::||||  .:.:.|  |.:|:||||:..|.::...|.:|:.|.  :.::.::|||
Mouse   638 ------ELIEALLKYI--ETLNVP--GAVLVFLPGWNLIYTMQKHLENNSHFG--SHRYQILPLH 690

  Fly   792 SALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVW 856
            |.:..|:|..||...|.|..|::|||||||||:||:|.|:|:|....|.|.|.::.||.:...||
Mouse   691 SQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVW 755

  Fly   857 VSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNT 921
            .|:.|.:|||||||||.||.|.||.:..|:. .:.....||:.|.||.:|.|.||.|:.......
Mouse   756 ASKTNLEQRKGRAGRVRPGFCFHLCSRARFD-RLETHMTPEMFRTPLHEIALSIKLLRLGGIGQF 819

  Fly   922 LSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLD 986
            |:   :.:|.|..|:|:.|...||::.||||.|:|||||..||.||::.|.||:|:.|.||...|
Mouse   820 LA---KAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGD 881

  Fly   987 SVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGN--SDHLTVLNAYRKWLDVARRGNYAASRN 1049
            :|.||:|......||:|. .||  .....|.|| ||  |||:.:|:.::.| |.||.....|...
Mouse   882 AVCTISAATCFPEPFISE-GKR--LGYIHRNFA-GNRFSDHVALLSVFQAW-DDARMSGEEAEIR 941

  Fly  1050 YASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNN-RL 1113
            :..:..|::.||....:.|.|..|:|::.|| |.|        |    .||.|..|...||| .:
Mouse   942 FCEQKRLNMATLRMTWEAKVQLKEILINSGF-PED--------C----LLTQVFTNTGPDNNLDV 993

  Fly  1114 LTSLLCAALYPNIV------KIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVN- 1171
            :.|||...:|||:.      ||:|                         |.|...: ||.||||
Mouse   994 VISLLAFGVYPNVCYHKEKRKILT-------------------------TEGRNAL-IHKSSVNC 1032

  Fly  1172 ---SQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWII 1233
               ||...:.:||.||.||:||.||..:..:::..:.::|||..  ||: .||..:|:  ..||.
Mouse  1033 PFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASK--KVQ-SDGQIVFI--DDWIR 1092

  Fly  1234 LK-AHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLL--------HHKNGCRMIA 1278
            |: :|  |.|..:..|||.|..|:.|..:.|  |::        |..|..|.|:
Mouse  1093 LQISH--EAAACITALRAAMEALVVEVSKQP--NIISQLDPVNEHMLNTIRQIS 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440	2/4 (50%)
		HrpA	419..1206	CDD:224557	283/801 (35%)
		DEXDc	471..619	CDD:238005	64/148 (43%)
		HELICc	781..871	CDD:197757	41/89 (46%)
		HA2	948..1029	CDD:214852	39/82 (48%)
		OB_NTP_bind	1070..1212	CDD:285018	47/152 (31%)
Dhx9	XP_011246220.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684
		DEXHc_DHX9	333..566	CDD:350730	87/248 (35%)
		HrpA	337..>1055	CDD:224557	285/808 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810