DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx57

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	1366	Identity:	533/1366 - (39%)
Similarity:	769/1366 - (56%)	Gaps:	156/1366 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PAAPKSQAADNKSR-----------KTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDR 79
            |..|......|||:           |..|..|.:..|:::.....||     :.|........:|
Mouse    71 PKRPSRPCDSNKSKGETRPKWKPKAKVPLQTLHMTSENQEKVKALLR-----DLQEQGADAGSER 130

  Fly    80 GRGGH--------GVKHSY--------------WQDRGTLVVQSVQ---GVSSTRGNDSDGDRLR 119
            |..|.        |.:..:              |:..|...|:...   .||.
Mouse   131 GTSGEEEDSEPQCGEEQGWPAGQEPIFLPDCSPWEYIGPEEVEPPVPECAVSP------------ 183

  Fly   120 RYALAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPP----SEQEILDM 180
             .|:.||..|||...||..|...|.||..|||..|.|:.......|::.|...    |..|.::.
Mouse   184 -LAVQKLSRYGFHTEHCQLALRICDGDLGAALEHLLRQCFSETFGERMALSEAAVYVSLNECVEQ 247

  Fly   181 RADEKEALESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKK 245
            |.:|..||:||..:.:.||..||||.:...:|:|    .::..|:::         .:::.:.:.
Mouse   248 RQEETLALKSICGEKFIERIQNRVWTIGLELDYL----TNKFCKSKQ---------KESSKNVRD 299

  Fly   246 KPPLRCRNFDRDGTCKYGPKCRFAH--LPQQ---PTESDTTKKDSVDENDNELWFHVEVRFPPGS 305
            ..|..|: |...|.||:|.||:|.|  .|.|   ..|.:........::|....:.:::||....
Mouse   300 TSPETCK-FYLKGNCKFGSKCKFKHEVPPHQMIGRAERNVNDPHLDADDDTTFMYELQIRFSKDH 363

  Fly   306 RYPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRL--- 367
            :|||:||.:...:|..::|...||..:..||.:|.|..:...|.|||:..||:...::...|
Mouse   364 KYPYQAPLVAFYSTNENLPLACRLHISEFLYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHT 428

  Fly   368 ---------DTSAFPS--------------PKRSLFYDEPAGG----GVNPDAEHHQSP------ 399
                     :....||              |..:...::...|    .:..||:..:.|
Mouse   429 QHKYSVPPVNVPPVPSETRISKPAYRKPVVPSNTFLSNQMLEGERLSELEEDADEDEGPASIIVE 493

  Fly   400 -------KPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFA 457
                   |...|.|         :.|..::...||.::.:||..::...::..|:..|:.|||:.
Mouse   494 NESYVNLKKRSYKR---------YDRPAKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWE 549

  Fly   458 EIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSA 522
            |.|.||.|:....||||||.|||||:||:|||||||    :|..|.:.   ...||||||||:||
Mouse   550 ERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDN----SLNGPPER---VANIICTQPRRISA 607

  Fly   523 IGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVH 587
            |.||||||.||.:|:|..||||||||:..|.:|||.:||||:|||||..|..|..|||:||||||
Mouse   608 ISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVH 672

  Fly   588 ERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDIL 652
            ||:||||||||:||:::.:|..|:||||||||:|.|||.||...||:.||||.|||.|.||||.|
Mouse   673 ERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLEDAL 737

  Fly   653 EMSDFVMEYDTKYCRKLK------------KQEQEILERELEYA-DVQASGEAPGKKIKDEKLTL 704
            .::.:|::..:.|.|.:|            :..||.:|.:|..: .:|...|:....|.|::|..
Mouse   738 AVTRYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEEDLRLSLHLQDEEESVKDTIPDQQLDF 802

  Fly   705 AETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVH 769
            .:...||...||...|::.:|:...:|.||||::|::||:|.|.:| .|.:|:||||..||:.::
Mouse   803 KQLLIRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYP-PGAVLVFLPGLAEIKMLY 866

  Fly   770 DSLLDNALF-SPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVV 833
            :.|..|:|| :.|:.:.::.||||:||.|:|..||.|.|.|..||::||||||||:||||.|:|:
Mouse   867 EQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVI 931

  Fly   834 DCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEI 898
            |.|.||||.:|:.:.||||:..:||:|||.|||||||||..|||.||:||:.|.:.:|.|.:|||
Mouse   932 DSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEI 996

  Fly   899 QRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHL 963
            |||||||:.||||.|:.|::.|..||....:|.|..||:..:..||||:|||..:::|||||:||
Mouse   997 QRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHL 1061

  Fly   964 AALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTV 1028
            |:||||||||||||.|:||:|||..|||||.|:.|||||||.:|:.||::.|..||..|||:|.:
Mouse  1062 ASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLAL 1126

  Fly  1029 LNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVP----RRR 1089
            |.||:.| .::.:.:..||.||..::|||..||:.:|.||.|:.|||..||||...:.    .:|
Mouse  1127 LCAYKGW-QLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKR 1190

  Fly  1090 KNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLR 1154
            ....|.:|..||.|.|.|.:|.:|::::||||||||:|::.||:..:.:|:.|.|..:|...:|:
Mouse  1191 AQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELK 1255

  Fly  1155 FKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELH 1219
            |.|:.||||.|||||||.||..|.:|:|::.||::||.::||||||:.:..:|||.|....|:|.
Mouse  1256 FVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQ 1320

  Fly  1220 DGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLLHHKNGCRMIANIVHLI 1284
            .|.|:..|:.|||...|...:.||:|:.||.|:.:||::||::|.::|.....|.|:|:.||.||
Mouse  1321 RGAFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSMDLCSCPRGSRIISMIVKLI 1385

  Fly  1285 S 1285
            :
Mouse  1386 T 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	14/30 (47%)
		zf-CCCH	250..272	CDD:279036	10/23 (43%)
		RWD	<284..360	CDD:283440	22/75 (29%)
		HrpA	419..1206	CDD:224557	396/804 (49%)
		DEXDc	471..619	CDD:238005	95/147 (65%)
		HELICc	781..871	CDD:197757	52/89 (58%)
		HA2	948..1029	CDD:214852	52/80 (65%)
		OB_NTP_bind	1070..1212	CDD:285018	65/145 (45%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154		4/32 (13%)
		UBA_DHX57	181..218	CDD:270502	17/49 (35%)
		RWD	246..419	CDD:368608	51/186 (27%)
		HrpA	501..1298	CDD:224557	395/814 (49%)
		DEVH box	669..672		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845709
Domainoid	1	1.000	185	1.000	Domainoid score	I3389
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56267
Inparanoid	1	1.050	872	1.000	Inparanoid score	I411
Isobase	1	0.950	-	0	Normalized mean entropy	S3191
OMA	1	1.010	-	-		QHG47570
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		oto93030
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1595
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750