DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and Dhx32

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001272959.1	Gene:	Dhx32 / 101437	MGIID:	2141813	Length:	751	Species:	Mus musculus

Alignment Length:	800	Identity:	206/800 - (25%)
Similarity:	347/800 - (43%)	Gaps:	164/800 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 NPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLP 454
            :|:|    ||:..::.....| :||..:..:..:..|    |..|.......||.|::..|::||
Mouse    15 HPNA----SPEKRYFPESLDS-SDGDEEGVLACEDLE----LNPFDGLPYSSRYYKLLKEREELP 70

  Fly   455 AFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRR 519
            .:.|....:..:..:.|||:||::.||||:||||:..:    ..|.:    :..|..:||||..:
Mouse    71 IWKEKYSFMESLLQNQVVVVSGDSKCGKSSQVPQWCAE----YCLSI----HYQHGGVICTQAHK 127

  Fly   520 LSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVD 584
            .:|:.:|.|||.|....||..|||.|..||..:..|.|.:||..:|.|.:.|:|.|||...:|:|
Mouse   128 QTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILD 192

  Fly   585 EVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLE 649
            :|||||..:|.||.:||::|..|.:||:|:..:.|..:..|.|:|..||:::..: .||:.::|
Mouse   193 DVHERSLATDVLLGLLKDVLLARPELKLIVNCSPLLTSKLSSYYGDVPVIEVRNK-HPVEVVYL- 255

  Fly   650 DILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEY 714
                                                   ||..     ||.
Mouse   256 ---------------------------------------SGAQ-----KDS-------------- 262

  Fly   715 SKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLL-DNALF 778
                                .|||::.|.| .|....:|.:::||....:|:..::.:. :.:..
Mouse   263 --------------------FESVIRLIFE-IHRSGEKGDVVVFLACEQDIEKTYELVCQEGSNL 306

  Fly   779 SPRAGKFILVPLHSALSGEDQALVF-------KKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCG 836
            :|..|..:::||:.    :::..:|       |:....:|::||:|:..|:.:......||:|.|
Mouse   307 NPDVGDLVVIPLYP----KEKCSLFRPVDETEKRCQVYQRRVVLTTSCGESLIWSHTVKFVIDVG 367

  Fly   837 LMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRV 901
            |.:.:.::......||.|..:|::.|:.||...|....|....|||.......:......|:|..
Mouse   368 LERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEA 432

  Fly   902 PLEQIVLRIKTLQTFASRNTLSVL--LETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLA 964
            .|..:||       |..|..::.|  .:.:..|..:|::.||..|..:.|||.:..|:..|..::
Mouse   433 NLTSMVL-------FMKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMS 490

  Fly   965 ALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVS-PLNKRTEADKCKRMFALGNSDHLTV 1028
            ..|:|.::.|.:|....|.|:|.:|||||.::..|.|:. |......|..|.:.|.....||.|:
Mouse   491 EFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTL 555

  Fly  1029 LNAYRKWLDVARRGNYAASRNYASEH---------FLSLNTLETIADLKYQYLELLVSIGFVPID 1084
            :|.|..:.|..        .|.|:||         |||.:.|.....::.:.||::..|. :|..
Mouse   556 INVYNAYQDTV--------LNSANEHCVEMWCHDCFLSCSALRMADVIRAELLEIIKRIE-LPYA 611

  Fly  1085 VPR--RRKNACDNI--LTLTG----VEQNHNGDNNRL-LTSLLCAALYP----NIVKIMTPDRV- 1135
            .|.  .::|.. ||  ..|:|    :.::.:|..|.| ||....|.|:|    :|.|.| |:.|
Mouse   612 EPAFGSKENGL-NIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSSYSITKKM-PEWVL 674

  Fly  1136 ----------YIQTAGGAVP 1145
                      ||:.|....|
Mouse   675 FHQFSISENNYIRVASAVSP 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	198/770 (26%)
		DEXDc	471..619	CDD:238005	61/147 (41%)
		HELICc	781..871	CDD:197757	22/96 (23%)
		HA2	948..1029	CDD:214852	26/81 (32%)
		OB_NTP_bind	1070..1212	CDD:285018	26/99 (26%)
Dhx32	NP_001272959.1	HrpA	19..687	CDD:224557	201/783 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900