DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and dhx29

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_004910409.1	Gene:	dhx29 / 100216168	XenbaseID:	XB-GENE-995260	Length:	1363	Species:	Xenopus tropicalis

Alignment Length:	1437	Identity:	441/1437 - (30%)
Similarity:	673/1437 - (46%)	Gaps:	301/1437 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDR 79
            |:|:::|       |..:....|......:|...|.|.|..        .||:..  ..:...|.
Frog    27 RAPTELR-------PGGEEVSKKQTPRTANVAPANKEPRNK--------QGPKTY--SFASSSDS 74

  Fly    80 GRGGHGVK-------HSYWQDRGTLVVQSVQGVSSTRGNDS---DGDRLRRYALAKLENYGFQAV 134
            |..|:..|       .:..:.|...::...:.::|.:|..|   ...:|:...:| |:...|||.
Frog    75 GVSGNHHKSVLKVVIEAKLEKRIISLINEHKKLNSNKGTVSGRLTSKKLQDLYMA-LQKLSFQAE 138

  Fly   135 HCLEAYEHC---SGDTEAAL--------------------------------------------- 151
            |..||..:.   .||..:||
Frog   139 HIEEAMTNTVLYGGDLHSALDWLCLNLPDDALPEGFSQQFVEEEQRARAKFQPPPQRPSAANVLG 203

  Fly   152 ---------------------LLLYRRYMRIPDEEQ-----LTLEPPSEQ------------EIL 178
                                 :|.|.......|||:     |...|.||:            ::|
Frog   204 TEKAKEGAAFKGNKELSMKEWILQYAEQGSDDDEEEEKETALEKHPTSEKFDPNERYLELTAKLL 268

  Fly   179 DMRAD------------EKEALESIFDKAYEER----EANRVWNLKFRIDHLLAHSPSEVRKARE 227
            |.||.            :|||.|.|  :.|::.    |.:.::|...:|..:    .||.::.|.
Frog   269 DARAQAAATKQDKDKQGQKEAQERI--RGYQQEMKSLEDHPLFNPAVKIPEV----KSESKQPRP 327

  Fly   228 AVLAAAAAA---------AQAALDK-KKKPPLRCRNFD---RDGTCKYGPK------CRFAHLPQ 273
            |:..:...:         ..|..|| ||||||..||||   |..|.| .||      || .|..:
Frog   328 ALPPSDEESLNFNLFEKIENAPEDKAKKKPPLDIRNFDYTSRSWTGK-SPKQFLIDWCR-KHYQK 390

  Fly   274 QPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIY----LKTTCHDIPHELRLRYARH 334
            .|..|                |.   :.|.|..:......|.    :...|..|..|..:: |:|
Frog   391 SPNPS----------------FE---KVPVGKYWKSRVKIIKSHDDVMCVCPTIVTEDSMQ-AQH 435

  Fly   335 ------LYKEAK-EICRDGIPCVYSICDL--------LQSNEQLAGRLDTSAFPSP---KRSLFY 381
                  ||:..| :.....:|..|....|        :|...::........|.:.   |..|..
Frog   436 LAATLALYELTKGQSVHQLLPPTYRDVWLEWSDAEKQVQEQNKMESNKPRDQFITKLLNKLKLQQ 500

  Fly   382 DEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVE-----AQTRENRRLLQQFVERRKEE 441
            ::....|.||..|   .|:.|.       .|....:..:|     |||.:...:....::.|...
Frog   501 NQLKSSGQNPVTE---DPEDSW-------ENLACDEEQIETCPSTAQTDDLEPIRNLLLKSRDSI 555

  Fly   442 RYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKEN 506
            :|:::::.|:|||.||..:.||..::...|:|::||||.|||||||||:|::..... ..|.|.|
Frog   556 KYKRLLNDREQLPVFAHRKFILETLKRHRVIVVAGETGSGKSTQVPQFLLEDLLLNR-GSPGKCN 619

  Fly   507 LPHVEIICTQPRRLSAIGVAERVAAERLDRIG---------QLVGYQIRLENKVSQSTRLSFCTT 562
                 |:||||||:||:.:|.||..|    :|         .|.|||||:|::..::|||.:|||
Frog   620 -----IVCTQPRRISAMSLATRVCEE----LGCDSGPGGRNSLCGYQIRMESRTGEATRLLYCTT 675

  Fly   563 GILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDY 627
            |||||:|..|.:|.:::|:||||||||:.:|||||:||:.:|.:|.||.::|||||::...||.|
Frog   676 GILLRKLQEDSMLKNISHIIVDEVHERTVQSDFLLIILREILHKRSDLHLVLMSATVDCEKFSSY 740

  Fly   628 FGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEA 692
            |...|::.|.||||||:...|||::|.:.||:|.|::||:|..:.|:||.      ..|...|.:
Frog   741 FTHCPIIRISGRTFPVEVFHLEDVVEATGFVLEQDSEYCQKFLEDEEEIT------LSVTGKGGS 799

  Fly   693 PGK------KIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPR 751
            ..|      .:.|..|.|.:.|||   ||..|..::..|.|..||.:||..:|.::.........
Frog   800 STKYQEFIPALSDTGLDLGQRYQR---YSSQTRHAVLYMNPNKINLDLILELLVFLDISPQYRNV 861

  Fly   752 EGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLS 816
            ||.:||||||..:||.::|.|..:..|..|. ::.|:.|||.||.:|||..|...|.|.|||||:
Frog   862 EGAVLIFLPGLADIQQLYDILSSDKRFHDRR-RYKLIALHSILSSQDQAEAFILPPAGTRKIVLA 925

  Fly   817 TNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLY 881
            ||||||.:||.|.|||||.|..||..:..:..|.||...::|:|:|.||:||||||..|.|..||
Frog   926 TNIAETGITIPDVVFVVDAGRTKENRYHESSQMSSLVETFISKASALQRQGRAGRVRDGFCFRLY 990

  Fly   882 TSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRD 946
            |..|:: ..:...||||.|||||::.|.|......:..:.||   :.|:.|....:..|:..||.
Frog   991 TRERFE-GFMEYSVPEILRVPLEELCLHIMKCDLGSPEDFLS---KALDPPQLQVISNAMNLLRK 1051

  Fly   947 VGALD-AEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTE 1010
            :||.: .:.:|||||.|||||||:|:|||::::||||.|||:|.|:||.::.|||||:|:.::..
Frog  1052 IGACELIQPRLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDAVATLAATMTEKSPFVTPIGEKDR 1116

  Fly  1011 ADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELL 1075
            ||..|...|:.||||||:..||..|..: |...|||..:|..::||:...|.||.|:|.:.:.|:
Frog  1117 ADLAKSSMAVANSDHLTIFRAYLGWKAI-RSDGYAAEMSYCRKNFLNRKALLTIEDVKQELIRLV 1180

  Fly  1076 VSIGFVPIDVPR--RRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRV--- 1135
            .:.||   :.||  ......||:..|:..|.:       ||.::|.|.||.|:.||:..:.|
Frog  1181 RAAGF---ECPRFVEPNGLSDNMKALSAEETS-------LLKAILTAGLYDNVGKILFTNSVDIT 1235

  Fly  1136 -----YIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYI 1195
                 .::||                   .|..::||||||..:..:  .:|::|||::.|.:::
Frog  1236 EKLACMVETA-------------------QGKAQVHPSSVNRDLQTY--GWLLYQEKIKYSKVFL 1279

  Fly  1196 RDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKI 1260
            |:.:::....::|| |.|..|:..:   ..|....||..:| .::.|.:.:.||..:..:|::|:
Frog  1280 RESTLITPFPVLLF-GGDIAVQHRE---RLLTVDDWIHFQA-PVKIAVIFKELRVLIESVLKKKL 1339

  Fly  1261 RDPCLNL 1267
            .:|.::|
Frog  1340 ENPKMSL 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	12/99 (12%)
		zf-CCCH	250..272	CDD:279036	12/30 (40%)
		RWD	<284..360	CDD:283440	16/94 (17%)
		HrpA	419..1206	CDD:224557	318/817 (39%)
		DEXDc	471..619	CDD:238005	78/156 (50%)
		HELICc	781..871	CDD:197757	46/89 (52%)
		HA2	948..1029	CDD:214852	45/81 (56%)
		OB_NTP_bind	1070..1212	CDD:285018	36/151 (24%)
dhx29	XP_004910409.1	HrpA	556..1281	CDD:224557	312/780 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9237
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010