DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1582 and dhx32a

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001189401.3	Gene:	dhx32a / 100006246	ZFINID:	ZDB-GENE-130613-6	Length:	728	Species:	Danio rerio

Alignment Length:	672	Identity:	167/672 - (24%)
Similarity:	288/672 - (42%)	Gaps:	132/672 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 LQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWF 495
            |.||.......||.:::..||.||.:......:.|:|::.::::||.|..|||||:||:..:  |
Zfish    30 LNQFDGLPYSSRYYRLLQERKTLPVWKYRHEFMTLLENNQILIVSGTTKTGKSTQIPQWCAE--F 92

  Fly   496 FRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFC 560
            ..:.|      ..|..::|:|.:|..|:.:|.|||.|....||..:||.|.||...|..|.|.:|
Zfish    93 CLSAQ------YQHGVVVCSQIQRRQAVDLALRVADEMDVNIGHEIGYSIPLETCCSNDTILRYC 151

  Fly   561 TTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFS 625
            |..||||.:.|||||.....|:||:.|||:..:|.||.:|:.:|.:|.:|:::::||........
Zfish   152 TDDILLREMMSDPLLEQYGVVLVDQAHERTVSTDVLLGLLREVLLQRPELRLVVLSAPPTPETLL 216

  Fly   626 DYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASG 690
            .::|..|.|.:
Zfish   217 THYGSVPRLHL------------------------------------------------------ 227

  Fly   691 EAP--GKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREG 753
            |||  |:.|..               |..:.:|.|             |.|:..:| .|.....|
Zfish   228 EAPSAGEVIHS---------------SSSSSESFY-------------SALRLALE-VHRSREPG 263

  Fly   754 TILIFLPGFGEIQSVHDSLLDNA-LFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLS- 816
            .:.:||....|:....:.:...| ..|...|:.:.||:.|..:|....:.  ::|...|:|.:|
Zfish   264 DVAVFLATEQEVVCACNIITKEASRMSVSLGELLAVPMCSGHAGICPPVT--ESPQMSRRIFVSC 326

  Fly   817 TNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLY 881
            :.:.:...::|...||:|.|:.|...::......|..:..:|:..|:.||...|..  |.|..||
Zfish   327 SQLEDLFWSVDSIAFVIDTGVEKRLVYNPRLRASSEVIRPISKCQAEMRKQLTGST--GKCFCLY 389

  Fly   882 TSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEA-----------PTED 935
                          ||..::|.|   :..:.|:  ::..:.::.|:.:||           |..:
Zfish   390 --------------PEDVQLPAE---IHPRILE--SNITSTALFLKRMEAAGVTHCHFINRPDPE 435

  Fly   936 SVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSP 1000
            .::.||..|..:.|||.:..|:.:|..::.||::.::.|.:|....|.|...:|||||.|:..|.
Zfish   436 GLMQALEELDYLAALDNDGNLSEMGIIMSELPLEPQMAKALLASCEFDCASEMLTIAAMLTAPSC 500

  Fly  1001 FVS-PLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETI 1064
            |:. |:...||..:|...|.....||.|::|.|..: ..::|..|.:...:..:::|....|:|.
Zfish   501 FIEPPVGMLTEVMRCHMKFQHPEGDHFTLINIYNTF-KRSQREPYFSQEQWCEQYYLCCAALQTA 564

  Fly  1065 ADLKYQYLELLVSIGFVPIDVP 1086
            ..::.|..::|..|. :||..|
Zfish   565 DAIRSQLSDVLKRIE-LPISEP 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	167/672 (25%)
		DEXDc	471..619	CDD:238005	58/147 (39%)
		HELICc	781..871	CDD:197757	20/90 (22%)
		HA2	948..1029	CDD:214852	27/81 (33%)
		OB_NTP_bind	1070..1212	CDD:285018	6/17 (35%)
dhx32a	NP_001189401.3	HrpA	14..>610	CDD:224557	167/672 (25%)
dhx32a	NP_001189401.3	OB_NTP_bind	569..678	CDD:311586	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900