Protein Alignment Ork1 and KCNK5

DIOPT Version :9

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_003731.1
• Gene: KCNK5 / 8645
• HGNCID: 6280
• Length: 499
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 137/554 - (24%)
• Similarity: 229/554 - (41%)
• Gaps: 97/554 - (17%)

  Fly     4 NRWILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEE---LGDKNTTTQDEI 65
            :|..||....|.||..||||:..:|....|    |.:|.......:||:|   ||.:..   |:|
Human     3 DRGPLLTSAIIFYLAIGAAIFEVLEEPHWK----EAKKNYYTQKLHLLKEFPCLGQEGL---DKI 60

  Fly    66 LQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI 130
            |:.:||...:.|.:  |.:.|...|.:.:|..||.||.:|:||||::|.|.|||:..:.|.:.|:
Human    61 LEVVSDAAGQGVAI--TGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGV 123

  Fly   131 PVNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWV 195
            |:.....:.||::||       .|.|:.........|..:...||..||.::.|:.:.|::|.:|
Human   124 PLCLTWISALGKFFG-------GRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFV 181

  Fly   196 FTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMI 260
            |...|.|.|...||||::|.:||||||:|.  |.|..   ..:..:|:.||.:|....|.:|.:.
Human   182 FMVTEGWNYIEGLYYSFITISTIGFGDFVA--GVNPS---ANYHALYRYFVELWIYLGLAWLSLF 241

  Fly   261 MTF-------ITRGLQSKKLAYLEQQLSS--NLKATQNRIWSGVTKDVGYLRRMLNELYILKVKF 316
            :.:       :.:.::.::....|...||  :.||.|.: .|..:|||...            .|
Human   242 VNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVK-GSTASKDVNIF------------SF 293

  Fly   317 CRKGNRKKPKNKAKTEQKKKSSRYIAYTL------------PRSNSCPDLSMYRVEPAPIPSRKR 369
            ..|      |.:...:..|:..:....|.            |:....|.|....| |..:.|:.|
Human   294 LSK------KEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLV-PLVVYSKNR 351

  Fly   370 AFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPPAEQ 434
            . ....::....|..|.|..:.|.|......|.:....|.:....|.:::        :..|.:.
Human   352 V-PTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISE--------ECEPWDA 407

  Fly   435 EDAALYGGYHG--FSDSQILASEWSFSTVNEFTSPRRPRARACSDFNL---EAPRW--QSERPLR 492
            :|      ||.  |.|:.|..........:|.||      ::..:.||   |:|:.  :::.||.
Human   408 QD------YHPLIFQDASITFVNTEAGLSDEETS------KSSLEDNLAGEESPQQGAEAKAPLN 460

  Fly   493 ----SSHNEWTWSGDNQQIQEAFNQRYKGQQRAN 522
                .|.:|.|::....::...:.|......:||
Human   461 MGEFPSSSESTFTSTESELSVPYEQLMNEYNKAN 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	21/53 (40%)
		Ion_trans_2	185..269	CDD:285168	27/90 (30%)
KCNK5	NP_003731.1	Ion_trans_2	<81..137	CDD:311712	21/55 (38%)
		Ion_trans_2	171..243	CDD:311712	27/76 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..335		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..388		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..499		15/73 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155188
Domainoid	1	1.000	65	1.000	Domainoid score	I10023
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm41289
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800