DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ork1 and Kcnk10

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_075584.1	Gene:	Kcnk10 / 65272	RGDID:	619732	Length:	538	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	86/319 - (26%)
Similarity:	154/319 - (48%)	Gaps:	43/319 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RW---ILLLIFYISYLMFGAAIYYHIEHGEEK-------ISRAEQRKAQIAINEYLLEELGDKNT 59
            :|   :.:.:..:.||:.|..::..:|...|.       :.:||..:..|.::...||.|
  Rat    68 KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETL----- 127

  Fly    60 TTQDEILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIA 124
                  :|...|..:..|:......::...|....|||||.||.:|:|||||:|:|..|::..|.
  Rat   128 ------IQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCIL 186

  Fly   125 YSVIGIPVNGILFAGLGE----YFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGI 185
            |::.|||:.|.|.||:|:    .||::...:.:.::|.::|      ..::.:|:|::. ::.|.
  Rat   187 YAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVS------QTKIRVISTILF-ILAGC 244

  Fly   186 ALFLLLPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWF 250
            .:|:.:|:.:|.|.|.|....|:|:..||.||:||||:|.  |.|....:..|   |:..|..|.
  Rat   245 IVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVA--GGNAGINYREW---YKPLVWFWI 304

  Fly   251 IFSLGYLVMIMTFITRGLQ--SKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLN 307
            :..|.|...:::.|...|:  |||    .::....:||......:.||.:....||.|:
  Rat   305 LVGLAYFAAVLSMIGDWLRVLSKK----TKEEVGEIKAHAAEWKANVTAEFRETRRRLS 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	27/57 (47%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	26/83 (31%)
Kcnk10	NP_075584.1	Ion_trans_2	148..206	CDD:400301	27/57 (47%)
		Ion_trans_2	244..323	CDD:400301	26/83 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..444
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349023
Domainoid	1	1.000	66	1.000	Domainoid score	I9680
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm45417
orthoMCL	1	0.900	-	-		OOG6_108298
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.740