DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ork1 and KCNK15

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_071753.2	Gene:	KCNK15 / 60598	HGNCID:	13814	Length:	330	Species:	Homo sapiens

Alignment Length:	282	Identity:	74/282 - (26%)
Similarity:	130/282 - (46%)	Gaps:	59/282 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINE--YLLEELGDKNTTTQDEILQRISD 71
            |::..:.||:.|||::..:|      |.||..:.::.:.:  .|..:.|......::  |:|::.
Human    11 LVLCTLCYLLVGAAVFDALE------SEAESGRQRLLVQKRGALRRKFGFSAEDYRE--LERLAL 67

  Fly    72 YCDKPVTLPPTYDDTPY----TWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPV 132
            ..:            |:    .|.|..:|:||.||.:|:.||:.:|.|.:|::..:.|:::|||:
Human    68 QAE------------PHRAGRQWKFPGSFYFAITVITTIEYGHAAPGTDSGKVFCMFYALLGIPL 120

  Fly   133 NGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITT------VVIALIPGIALFLLL 191
            ..:.|..|||    ...|:.||.        :......|||..|      :|:|.:...|..|.|
Human   121 TLVTFQSLGE----RLNAVVRRL--------LLAAKCCLGLRWTCVSTENLVVAGLLACAATLAL 173

  Fly   192 PSWVFTYFENWPYSISLYYSYVTTTTIGFGDYV--PTFGANQPKEFGGWFVVYQIFVIVWFIFSL 254
            .:..|::||.|.:..:.||.::|.|||||||:|  .:..|.|.|             :.:..||.
Human   174 GAVAFSHFEGWTFFHAYYYCFITLTTIGFGDFVALQSGEALQRK-------------LPYVAFSF 225

  Fly   255 GYLVMIMTFITRGLQSKKLAYL 276
            .|:::.:|.|...|....|.:|
Human   226 LYILLGLTVIGAFLNLVVLRFL 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	21/53 (40%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	26/85 (31%)
KCNK15	NP_071753.2	Ion_trans_2	<77..132	CDD:285168	21/58 (36%)
		Ion_trans_2	176..243	CDD:285168	24/79 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910