DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and kcnk5a

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001032478.1	Gene:	kcnk5a / 570159	ZFINID:	ZDB-GENE-051113-112	Length:	513	Species:	Danio rerio

Alignment Length:	559	Identity:	142/559 - (25%)
Similarity:	229/559 - (40%)	Gaps:	97/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISDY 72
            ||....|.||..||||:..||....:|:..:.|    |..|.:|::.........|.||:.:||.
Zfish     7 LLTSAIIFYLSIGAAIFQVIEEPNWEIAVRKYR----ADKESILKQYPCLTKADLDYILEVVSDA 67

  Fly    73 CDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILF 137
            ..:.:|:  |.|.|...|.:.:|..||.||.:|:|||||:|.|.:||:..|.|.:.|:|:.....
Zfish    68 AGQGITI--TGDKTFNNWNWPNAVIFAATVITTIGYGNIAPKTPSGRVFCIFYGLFGVPLCFTWI 130

  Fly   138 AGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVFTYFENW 202
            :.||::||       .|.|..........|..:...:|...:.|:.|:.:.|::|.:||...|.|
Zfish   131 SELGKFFG-------GRAKHLGWYLTKKGVTLRKTQLTCTAVFLLWGVLIHLVIPPFVFMTQEGW 188

  Fly   203 PYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTFITRG 267
            .|...||:|:||.|||||||.|.  |.:...|:.   .:|:.||.||....|.:|.:...:..|.
Zfish   189 TYIEGLYFSFVTLTTIGFGDLVA--GVDPNAEYP---TLYRYFVEVWIYLGLAWLSLFFNWKVRM 248

  Fly   268 L-----------QSKKLAYLEQQLSS-----NLKATQN--RIWSGVT-KDVGYLRRMLNELYILK 313
            :           :.::|:..|.||..     :|..|.|  .|:|.:: |..||     |:|
Zfish   249 VVEAHKALKKHRKRRRLSLDELQLKESHKTLHLPPTPNDVNIFSFLSKKKEGY-----NDL---- 304

  Fly   314 VKFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDL------SMYRVEPAPIPSRKRAFS 372
            :|  :.|..|.......|...:|::     ...||.||.|.      ::..::.:|...|..:||
Zfish   305 IK--QIGADKGENQCVSTMNSRKNA-----AAKRSKSCSDALSINGNTIVSLDGSPRLKRHYSFS 362

  Fly   373 VCADMVAA--QREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPPAEQE 435
               |.||.  .:..|.:.:..:..|.....|:....::....:.:.|.|           .|.:.
Zfish   363 ---DRVAVALSKSKGYLFSQEECLLMTEKLEEGDTDSQCMGMSENQLDK-----------EAGES 413

  Fly   436 DAALYGGYHGFSDSQILASEW---------------SFSTVNEFTSPRRPRAR-ACSDFNLEAPR 484
            ..||..  .|..:|||   .|               :|...:.|.:..|.... ....|..:.|.
Zfish   414 HKALIS--EGCRNSQI---TWDSKGHQTNMFPNANITFIDEDNFVNNNREDENDFMPSFKSDEPD 473

  Fly   485 WQSERPLRSSHNEWTWSG-DNQQIQEAFNQRYKGQQRAN 522
            ::.|....|..:.:|..| |:.|..|...:.|..:...:
Zfish   474 FRKEEDSESETSVFTGCGSDHGQSYERLVEEYSKEDNTD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	22/53 (42%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	30/94 (32%)
kcnk5a	NP_001032478.1	Ion_trans_2	<81..137	CDD:285168	22/55 (40%)
kcnk5a	NP_001032478.1	Ion_trans_2	171..243	CDD:285168	29/76 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590283
Domainoid	1	1.000	61	1.000	Domainoid score	I10431
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800