DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and KCNK4

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001304019.1	Gene:	KCNK4 / 50801	HGNCID:	6279	Length:	393	Species:	Homo sapiens

Alignment Length:	408	Identity:	111/408 - (27%)
Similarity:	179/408 - (43%)	Gaps:	80/408 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISD 71
            :.||...:.||:.||.::..:|...|       ::||..:.|...:.|......:..|:...|.:
Human     7 LALLALVLLYLVSGALVFRALEQPHE-------QQAQRELGEVREKFLRAHPCVSDQELGLLIKE 64

  Fly    72 YCD------KPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI 130
            ..|      .|.| ..|.:.:...|....||||:.|:.:|:||||::..|.|||:..|.|:::||
Human    65 VADALGGGADPET-NSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGI 128

  Fly   131 PVNGILFAGLGEYFGRT-------FEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALF 188
            |:.|||.||:|:..|.:       .|||:.::          :|||:|..:.:.::.|:.|..||
Human   129 PLFGILLAGVGDRLGSSLRHGIGHIEAIFLKW----------HVPPELVRVLSAMLFLLIGCLLF 183

  Fly   189 LLLPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFS 253
            :|.|::||.|.|:|....::|:..||.||:||||||.  ||: |::..   ..||..|..|.:..
Human   184 VLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVA--GAD-PRQDS---PAYQPLVWFWILLG 242

  Fly   254 LGYLVMIMTFITRGLQ------SKKLAYLEQQLSSNLKATQNRIWSG-VTKDVGYLRRMLNELYI 311
            |.|...::|.|...|:      ..::..|..|.:|         |:| ||..|..
Human   243 LAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAAS---------WTGTVTARVTQ---------- 288

  Fly   312 LKVKFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEPAPIPSRKRAFSVCAD 376
                  |.|....|..|.:...............|||.|.|:    :.:| |.|....|....::
Human   289 ------RAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPE----KAQP-PSPPTASALDYPSE 342

  Fly   377 MVAAQREAGMVHANSDTE 394
            .:|      .:..:|||:
Human   343 NLA------FIDESSDTQ 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	26/53 (49%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	31/83 (37%)
KCNK4	NP_001304019.1	Ion_trans_2	<88..142	CDD:400301	26/53 (49%)
		Selectivity filter 1. /evidence=ECO:0000269\|PubMed:22282805, ECO:0000269\|PubMed:23341632, ECO:0000269\|PubMed:25471887, ECO:0000269\|PubMed:25500157	103..108		3/4 (75%)
		Ion_trans_2	180..258	CDD:400301	31/83 (37%)
		Selectivity filter 2. /evidence=ECO:0000269\|PubMed:22282805, ECO:0000269\|PubMed:23341632, ECO:0000269\|PubMed:25471887, ECO:0000269\|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..393		18/97 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155189
Domainoid	1	1.000	65	1.000	Domainoid score	I10023
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4331
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm41289
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4706
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.020