DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and kcnk5b

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_956927.1	Gene:	kcnk5b / 393606	ZFINID:	ZDB-GENE-040426-1297	Length:	448	Species:	Danio rerio

Alignment Length:	499	Identity:	131/499 - (26%)
Similarity:	207/499 - (41%)	Gaps:	125/499 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEY------LLEELGDKNTTTQDEILQ 67
            ::|||:|   .||||:..:          |:.....|:::|      ||::....:.....||::
Zfish    11 VIIFYLS---IGAAIFQIL----------EEPNLNSAVDDYKNKTNNLLKKYPCLSKEVLGEIIE 62

  Fly    68 RISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPV 132
            .:::...:.||:  |.:.....|.:.:|..||.||.:|:||||::|.|..||:..|.|.:.|||:
Zfish    63 VVAEATGQGVTV--TKEAQFNNWNWENAVIFAATVITTIGYGNVAPKTTGGRLFCILYGLCGIPL 125

  Fly   133 NGILFAGLGEYFG-RTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVF 196
            .....:.||.:|| ||     :|..:..:.:.::....|  .|.|:|. |:.|..:.|::|::||
Zfish   126 CLTWISELGTFFGSRT-----KRLSQLLLHSGLNVRKVQ--FICTIVF-LLWGFLVHLIIPAFVF 182

  Fly   197 TYFENWPYSISLYYSYVTTTTIGFGDYV----PTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYL 257
            .:||||.|...||:|:.|.||:||||||    |:  .|.|       .:|:.||.:|....|.:|
Zfish   183 MFFENWTYLEGLYFSFTTLTTVGFGDYVAGVDPS--VNYP-------TLYRFFVQLWIYLGLAWL 238

  Fly   258 VMIMTF-ITRGLQSKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKFCRKGN 321
            .:..:: :...:::.|:          ||..:.|.....|.||..                :|..
Zfish   239 SLFFSWNVHMVVEAHKV----------LKKRRMRRHRLPTDDVPE----------------KKEV 277

  Fly   322 RKKPKNKAKT----------------------------EQKKKSSRYIAYTLPRSNSCPDLSMYR 358
            :|.||...::                            .:|||....:|    ||.||.||....
Zfish   278 KKTPKPPPRSGVIDIFEFMSEKVEDYSDVIRAIGADEKRRKKKQEEELA----RSKSCSDLLQGL 338

  Fly   359 VEPAP-IPSRKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVN 422
            |.|.. .|..:|.|||.|:|..         |.||..:..|:....       :|..|.|.||.:
Zfish   339 VIPLDHSPRLQRRFSVSANMCM---------AISDESVDGLNNNNC-------KQEDDTLTKVRH 387

  Fly   423 ALATVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTS 466
            ....|....||......:....  ||..|..|    |||...|:
Zfish   388 KDQKVNRERAENPARCAWDSRS--SDPSIFQS----STVTNSTN 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	22/53 (42%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	30/88 (34%)
kcnk5b	NP_956927.1	Ion_trans_2	<81..137	CDD:285168	22/55 (40%)
		Ion_trans	<142..234	CDD:278921	35/103 (34%)
		Ion_trans_2	171..243	CDD:285168	30/80 (38%)
		C_Hendra	258..>323	CDD:293426	11/80 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590282
Domainoid	1	1.000	61	1.000	Domainoid score	I10431
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.800