DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ork1 and KCNK3

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_002237.1	Gene:	KCNK3 / 3777	HGNCID:	6278	Length:	394	Species:	Homo sapiens

Alignment Length:	276	Identity:	69/276 - (25%)
Similarity:	134/276 - (48%)	Gaps:	35/276 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RWILLLIFYISYLMFGAAIYYHIEHGEEKIS------RAEQRKAQIAINEYLLEELGDKNTTTQD 63
            |.:.|::...:||:.|||::..:|...|.|.      |.::.:|:..:::...|||        :
Human     7 RTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEEL--------E 63

  Fly    64 EILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVI 128
            .::.|:     ||       ......|.|..:|:||.||.:|:|||:.:|:|..|::..:.|:::
Human    64 RVVLRL-----KP-------HKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALL 116

  Fly   129 GIPVNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPS 193
            |||:..::|..|||........:..|.||     .:......:.:...|:|.....|:. |.:.:
Human   117 GIPLTLVMFQSLGERINTLVRYLLHRAKK-----GLGMRRADVSMANMVLIGFFSCIST-LCIGA 175

  Fly   194 WVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYL- 257
            ..|:::|:|.:..:.||.::|.||||||||| ....:|..:....:|.:....|:..:..:|..
Human   176 AAFSHYEHWTFFQAYYYCFITLTTIGFGDYV-ALQKDQALQTQPQYVAFSFVYILTGLTVIGAFL 239

  Fly   258 -VMIMTFITRGLQSKK 272
             ::::.|:|...:.:|
Human   240 NLVVLRFMTMNAEDEK 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	22/53 (42%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	23/85 (27%)
KCNK3	NP_002237.1	Ion_trans_2	<77..132	CDD:400301	22/54 (41%)
		Ion_trans_2	167..247	CDD:400301	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..286
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860