Protein Alignment Ork1 and KCNK1

DIOPT Version :9

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_002236.1
• Gene: KCNK1 / 3775
• HGNCID: 6272
• Length: 336
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 91/369 - (24%)
• Similarity: 161/369 - (43%)
• Gaps: 87/369 - (23%)

  Fly     9 LLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISDYC 73
            |::.|:.||:|||.::..:|...|.:.|.|.||    :....|||....:....::.|.|:.:..
Human    26 LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRK----LKRRFLEEHECLSEQQLEQFLGRVLEAS 86

  Fly    74 DKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFA 138
            :..|::....... :.|.|..|.|||.||.||.|||:..|.:..|:...|.|||||||.. :||
Human    87 NYGVSVLSNASGN-WNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFT-LLF- 148

  Fly   139 GLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGL---ITTVVIALIPG---IALFLLLPSWVFT 197
                     ..|:.:|...:.....:.|...:.|.   :..:|.|::.|   ::.|..:|:.||:
Human   149 ---------LTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFS 204

  Fly   198 YFE-NWPYSISLYYSYVTTTTIGFGDYVPTFGANQP-KEFGGWFVVYQIFVIVWFIFSL-GYLVM 259
            ..| :|.:..|.|:.:::.:|||.|||||..|.||. :|      :|:|.:..:.:..| ..||:
Human   205 VLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRE------LYKIGITCYLLLGLIAMLVV 263

  Fly   260 IMTF--ITRGLQSKKLAYLEQ-------------QLSSNLKATQNRIWSGVTKDVGYLRRMLNEL 309
            :.||  :....:.:|:.|:::             |||          :|.:|.....::
Human   264 LETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLS----------FSSITDQAAGMK------ 312

  Fly   310 YILKVKFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPD 353
                                  |.:|::..::|   .:|::|.|
Human   313 ----------------------EDQKQNEPFVA---TQSSACVD 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	25/53 (47%)
		Ion_trans_2	185..269	CDD:285168	27/88 (31%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	27/66 (41%)
		pore-forming domain	107..123		11/15 (73%)
		Ion_trans_2	192..267	CDD:400301	25/80 (31%)
		pore-forming domain	212..238		11/25 (44%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478	293..299		0/5 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740