DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ork1 and KCNA5

DIOPT Version :10

Sequence 1:NP_001285097.1 Gene:Ork1 / 32020 FlyBaseID:FBgn0017561 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens


Alignment Length:249 Identity:53/249 - (21%)
Similarity:94/249 - (37%) Gaps:77/249 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 EYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVF--------TY 198
            :..|:|.:|..|                :|||:   :..|..|:.||   .|.|:        |:
Human   421 QILGKTLQASMR----------------ELGLL---IFFLFIGVILF---SSAVYFAEADNQGTH 463

  Fly   199 FENWPYSISLYYSYVTTTTIGFGDYVP-TFGANQPKEFGGWFVVYQIFVIVW----FIFSLGYLV 258
            |.:.|  .:.:::.||.||:|:||..| |.|.   |..|....:..:..|..    .:.:..|  
Human   464 FSSIP--DAFWWAVVTMTTVGYGDMRPITVGG---KIVGSLCAIAGVLTIALPVPVIVSNFNY-- 521

  Fly   259 MIMTFITRGLQSKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKFCRKGNRK 323
                |..|....::.|.|:::     :.||::   |...|.|..|::...    :..||:.|...
Human   522 ----FYHRETDHEEPAVLKEE-----QGTQSQ---GPGLDRGVQRKVSGS----RGSFCKAGGTL 570

  Fly   324 KPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVE-PAPIPSRKRAFSVCAD 376
            :..:.|                 |..||| |....|: .:.:..|:..:::|.|
Human   571 ENADSA-----------------RRGSCP-LEKCNVKAKSNVDLRRSLYALCLD 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ork1NP_001285097.1 Ion_trans_2 83..144 CDD:462301 0/1 (0%)
Ion_trans_2 185..266 CDD:462301 22/93 (24%)
KCNA5NP_002225.2 Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952 1..211
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_POZ 120..246 CDD:453885
Ion_trans 249..526 CDD:459842 31/137 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 3/9 (33%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559 8/34 (24%)
PDZ-binding. /evidence=ECO:0000250 611..613
Blue background indicates that the domain is not in the aligned region.

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